scholarly journals Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND

2015 ◽  
Vol 30 (8) ◽  
pp. 1322-1329 ◽  
Author(s):  
Mariana Murea ◽  
Fang-Chi Hsu ◽  
Amanda J. Cox ◽  
Christina E. Hugenschmidt ◽  
Jianzhao Xu ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Functional Assessment ◽  
European Americans ◽  
Heart Study ◽  
Diabetes Heart Study ◽  
The Brain

scholarly journals Kidney Disease and Cognitive Function: African American-Diabetes Heart Study MIND

2014 ◽  
Vol 40 (3) ◽  
pp. 200-207 ◽  
Author(s):  
Nicholette D. Palmer ◽  
Kaycee M. Sink ◽  
Susan Carrie Smith ◽  
Jianzhao Xu ◽  
Donald W. Bowden ◽  
...  
Keyword(s):  
African American ◽  
Cognitive Function ◽  
Kidney Disease ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Mariana Murea ◽  
Thomas C Register ◽  
Jasmin Divers ◽  
Donald W Bowden ◽  
J Jeffrey Carr ◽  
...  
Keyword(s):  
African American ◽  
Kidney Disease ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Cerebral Structural Changes in Diabetic Kidney Disease: African American–Diabetes Heart Study MIND

Diabetes Care ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Kaycee M. Sink ◽  
Jasmin Divers ◽  
Christopher T. Whitlow ◽  
Nicholette D. Palmer ◽  
S. Carrie Smith ◽  
...  
Keyword(s):  
African American ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Structural Changes ◽  
Diabetic Kidney ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals JC Viruria Is Associated With Reduced Risk of Diabetic Kidney Disease

2019 ◽  
Vol 104 (6) ◽  
pp. 2286-2294 ◽  
Author(s):  
Etty Kruzel-Davila ◽  
Jasmin Divers ◽  
Gregory B Russell ◽  
Zipi Kra-Oz ◽  
Moran Szwarcwort Cohen ◽  
...  
Keyword(s):  
African American ◽  
African Americans ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Kidney Injury ◽  
Joint Analysis ◽  
Inverse Association ◽  
Diabetic Kidney ◽  
Heart Study ◽  
Diabetes Heart Study

Abstract Purpose African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

scholarly journals Genetic Mapping of Vascular Calcified Plaque Loci on Chromosome 16p in European Americans from the Diabetes Heart Study

2011 ◽  
Vol 75 (2) ◽  
pp. 222-235 ◽  
Author(s):  
Allison B. Lehtinen ◽  
Amanda J. Cox ◽  
Julie T. Ziegler ◽  
V. Saroja Voruganti ◽  
Jianzhao Xu ◽  
...  
Keyword(s):  
Genetic Mapping ◽  
European Americans ◽  
Heart Study ◽  
Calcified Plaque ◽  
Diabetes Heart Study

scholarly journals Relations of liver fat with prevalent and incident chronic kidney disease in the Framingham Heart Study: A secondary analysis

2019 ◽  
Vol 39 (8) ◽  
pp. 1535-1544 ◽  
Author(s):  
Robert M. Wilechansky ◽  
Alison Pedley ◽  
Joseph M. Massaro ◽  
Udo Hoffmann ◽  
Emelia J. Benjamin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Framingham Heart Study ◽  
Secondary Analysis ◽  
Liver Fat ◽  
Heart Study ◽  
Incident Chronic Kidney Disease

Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR

2014 ◽  
Vol 25 (3) ◽  
pp. 652-660 ◽  
Author(s):  
Zhiling Liu ◽  
Ying Xu ◽  
Jie Zhang ◽  
Junhui Zhen ◽  
Rong Wang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Diffusion Tensor Imaging ◽  
Kidney Disease ◽  
Functional Assessment ◽  
Diffusion Tensor ◽  
3T Mr

Abstract MP74: Long Term Risk-Factor Profiles for Chronic Kidney Disease in the Framingham Heart Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Gearoid M McMahon ◽  
Sarah R Preis ◽  
Shih-Jen Hwang ◽  
Caroline S Fox
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Framingham Heart Study ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Standard Deviation Increase ◽  
Heart Study ◽  
Increased Risk

Background: Chronic Kidney Disease (CKD) is an important public health issue and is associated with an increased risk of cardiovascular disease. Risk factors for CKD are well established, but most are typically assessed at or near the time of CKD diagnosis. Our hypothesis was that risk factors for CKD are present earlier in the course of the disease. We compared the prevalence of risk factors between CKD cases and controls at time points up to 30 years prior to CKD diagnosis. Methods: Participants were drawn from the Framingham Heart Study Offspring cohort. CKD was defined as an estimated glomerular filtration rate of ≤60ml/min/1.73m2. Incident CKD cases occurring at examination cycles 6, 7, and 8 were age- and sex-matched 1:2 to controls. Risk factors including systolic blood pressure (SBP), hypertension, lipids, diabetes, smoking status, body mass index (BMI) and dipstick proteinuria were measured at the time of CKD diagnosis and 10, 20 and 30 years prior. Logistic regression models, adjusted for age, sex, and time period, were constructed to compare risk factor profiles at each time point between cases and controls Results: During follow-up, 441 new cases of CKD were identified and these were matched to 882 controls (mean age 69.2 years, 52.4% women). Up to 30 years prior to CKD diagnosis, those who ultimately developed CKD were more likely to have hypertension (OR 1.74, CI 1.21-2.49), be obese (OR 1.74, CI 1.15-2.63) and have higher triglycerides (OR 1.43, CI 1.12-1.84, p=0.005 per 1 standard deviation increase). Each 10mmHg increase in SBP was associated with an OR of 1.22 for future CKD (95% CI 1.10-1.35) Additionally, cases were more likely to have diabetes (OR 2.90, CI 1.59-5.29) and be on antihypertensive therapy (OR 1.65, CI 1.14-2.40, p=0.009) up to 20 years prior to diagnosis. Increasing HDLc was associated with a lower risk of CKD (OR 0.84, CI 0.81-0.97 per 10mg/dl). Conclusions: As many as 30 years prior to diagnosis, risk factors for CKD are identifiable. In particular, modifiable risk factors such as obesity, hypertension and dyslipidemia are present early in the course of the disease. These findings demonstrate the importance of early identification of risk factors in patients at risk of CKD through a life-course approach.

scholarly journals Cultural variation in the gray matter volume of the prefrontal cortex is moderated by the dopamine D4 receptor gene (DRD4)

2018 ◽  
Vol 29 (9) ◽  
pp. 3922-3931 ◽  
Author(s):  
Qinggang Yu ◽  
Nobuhito Abe ◽  
Anthony King ◽  
Carolyn Yoon ◽  
Israel Liberzon ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Orbitofrontal Cortex ◽  
Receptor Gene ◽  
Cultural Influences ◽  
Dopamine D4 Receptor ◽  
East Asians ◽  
European Americans ◽  
The Difference ◽  
D4 Receptor ◽  
The Brain

Abstract Recent evidence suggests a systematic cultural difference in the volume/thickness of prefrontal regions of the brain. However, origins of this difference remain unclear. Here, we addressed this gap by adopting a unique genetic approach. People who carry the 7- or 2-repeat (7/2-R) allele of the dopamine D4 receptor gene (DRD4) are more sensitive to environmental influences, including cultural influences. Therefore, if the difference in brain structure is due to cultural influences, it should be moderated by DRD4. We recruited 132 young adults (both European Americans and Asian-born East Asians). Voxel-based morphometry showed that gray matter (GM) volume of the medial prefrontal cortex and the orbitofrontal cortex was significantly greater among European Americans than among East Asians. Moreover, the difference in GM volume was significantly more pronounced among carriers of the 7/2-R allele of DRD4 than among non-carriers. This pattern was robust in an alternative measure assessing cortical thickness. A further exploratory analysis showed that among East Asian carriers, the number of years spent in the U.S. predicted increased GM volume in the orbitofrontal cortex. The present evidence is consistent with a view that culture shapes the brain by mobilizing epigenetic pathways that are gradually established through socialization and enculturation.

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