scholarly journals Cerebral Structural Changes in Diabetic Kidney Disease: African American–Diabetes Heart Study MIND

Diabetes Care ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Kaycee M. Sink ◽  
Jasmin Divers ◽  
Christopher T. Whitlow ◽  
Nicholette D. Palmer ◽  
S. Carrie Smith ◽  
...  
Keyword(s):  
African American ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Structural Changes ◽  
Diabetic Kidney ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals JC Viruria Is Associated With Reduced Risk of Diabetic Kidney Disease

2019 ◽  
Vol 104 (6) ◽  
pp. 2286-2294 ◽  
Author(s):  
Etty Kruzel-Davila ◽  
Jasmin Divers ◽  
Gregory B Russell ◽  
Zipi Kra-Oz ◽  
Moran Szwarcwort Cohen ◽  
...  
Keyword(s):  
African American ◽  
African Americans ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Kidney Injury ◽  
Joint Analysis ◽  
Inverse Association ◽  
Diabetic Kidney ◽  
Heart Study ◽  
Diabetes Heart Study

Abstract Purpose African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

scholarly journals Kidney Disease and Cognitive Function: African American-Diabetes Heart Study MIND

2014 ◽  
Vol 40 (3) ◽  
pp. 200-207 ◽  
Author(s):  
Nicholette D. Palmer ◽  
Kaycee M. Sink ◽  
Susan Carrie Smith ◽  
Jianzhao Xu ◽  
Donald W. Bowden ◽  
...  
Keyword(s):  
African American ◽  
Cognitive Function ◽  
Kidney Disease ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Mariana Murea ◽  
Thomas C Register ◽  
Jasmin Divers ◽  
Donald W Bowden ◽  
J Jeffrey Carr ◽  
...  
Keyword(s):  
African American ◽  
Kidney Disease ◽  
Heart Study ◽  
Diabetes Heart Study

MO636THE ROLE OF DIFFUSION-WEIGHTED MRI AND APPARENT DIFFUSION COEFFICIENT IN ASSESSMENT OF DIABETIC KIDNEY DISEASE: PRELIMINARY EXPERIENCE STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mohamed Taha
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Structural Changes ◽  
University Hospital ◽  
Poor Correlation ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Adc Value ◽  
Diabetic Kidney ◽  
Adc Values

Abstract Background and Aims Diabetic kidney disease is the most common cause of ESRD. There is poor correlation between the degree of renal fibrosis and current screening markers. A noninvasive imaging technique is needed to assess the degree of structural changes in the kidney. Method Forty adult diabetic patients with chronic kidney disease as well as 20 age- and sex-matched adult healthy controls were recruited from Nephrology Department of our University Hospital. All patients underwent renal MR-DWI and ADC mapping on a 1.5-T scanner (Philips Achieva) using phased array body coil. Results Among the studied 40 diabetic patients, five groups of patients were resulted 8 patients for each and the ADC values were inversely correlated with advancement in renal parenchymal affection, ie, in late stages of the disease the ADC values were lower than in early stages. The mean ADC values of renal parenchyma in patients with diabetic kidney disease were considerably lower than that of healthy controls with normal renal function (2.1± 0.3x10− 3 mm2/s vs 2.4± 0.1x10− 3 mm2/s with p< 0.001). Conclusion ADC value is a possible noninvasive technique in evaluating the stage of renal dysfunction with assessment of disease progression.

scholarly journals Evaluation of Candidate Nephropathy Susceptibility Genes in a Genome-Wide Association Study of African American Diabetic Kidney Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88273 ◽  
Author(s):  
Nicholette D. Palmer ◽  
Maggie C. Y. Ng ◽  
Pamela J. Hicks ◽  
Poorva Mudgal ◽  
Carl D. Langefeld ◽  
...  
Keyword(s):  
African American ◽  
Kidney Disease ◽  
Association Study ◽  
Diabetic Kidney Disease ◽  
Genome Wide Association Study ◽  
Susceptibility Genes ◽  
Genome Wide Association ◽  
Diabetic Kidney ◽  
Genome Wide ◽  
A Genome

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine

2015 ◽  
Vol 42 (6) ◽  
pp. 418-424 ◽  
Author(s):  
Krishnamurthy P. Gudehithlu ◽  
Ignacio Garcia-Gomez ◽  
Jane Vernik ◽  
Carolyn Brecklin ◽  
Mark Kraus ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Structural Changes ◽  
Sandwich Elisa ◽  
Kidney Tissue ◽  
Protein Markers ◽  
Gelatinase Activity ◽  
Diabetic Kidney ◽  
Urinary Exosomes ◽  
Whole Urine

Background: Predicting or diagnosing underlying kidney disease by analyzing whole urine remains the mainstay of nephrology practice. However, whole urine is a poor compartment to assess many structural changes in the kidney because whole urine contains only a few proteins derived from the kidney itself. Urinary exosomes, on the other hand, which are derived from the kidney, contain proteins secreted by the kidney. We experimentally tested the hypothesis that ‘urinary exosomes more faithfully represent changes in the kidney tissue than whole urine'. A direct comparison between whole urine and urine exosomal levels of two chosen kidney disease markers, gelatinase and ceruloplasmin, was carried out on diabetic kidney disease patients. Methods: Urinary exosomes were separated from whole urine by sequential centrifugation including ultra-centrifugation. Gelatinase activity was measured using fluorosceinated gelatin as the substrate, and ceruloplasmin was measured by sandwich ELISA. A few kidney specimens from patients biopsied for atypical features were histochemically stained for validation of the biochemical results. Results: We found that changes in both, gelatinase (decreased activity) and ceruloplasmin (increased levels), in the urinary exosomes of diabetic kidney patients were in agreement with the alterations of these two proteins in the kidney tissue. In contrast, the levels of these two proteins in whole urine were highly variable and did not correlate with levels in the diabetic kidney tissue. Conclusion: In conclusion, these results confirmed our hypothesis that protein markers in urinary exosomes better reflected the underlying protein changes in the kidney than in whole urine samples.

Systems Medicine Derived Biomarkers to Assess How Canagliflozin Delays Progression of Diabetic Kidney Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1126-P
Author(s):  
HIDDO LAMBERS. HEERSPINK ◽  
PAUL PERCO ◽  
JOHANNES LEIERER ◽  
MICHAEL K. HANSEN ◽  
ANDREAS HEINZEL ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Systems Medicine ◽  
Diabetic Kidney

Factors Related to the High Prevalence of Diabetic Kidney Disease in Ecuador-Update for Health Policy Makers

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 526-P
Author(s):  
MARIANA E. GUADALUPE ◽  
GRACIELA B. ALVAREZ CONDO ◽  
FANNY E. VERA LORENTI ◽  
BETTY J. PAZMIÑO GOMEZ ◽  
EDGAR I. RODAS NEIRA ◽  
...  
Keyword(s):  
Health Policy ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Policy Makers ◽  
Diabetic Kidney ◽  
High Prevalence

Albuminuria Is More Closely Associated with Vascular Endothelial Function than eGFR in Type 2 Diabetes with Diabetic Kidney Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 443-P
Author(s):  
YOSHINORI KAKUTANI ◽  
MASANORI EMOTO ◽  
YUKO YAMAZAKI ◽  
KOKA MOTOYAMA ◽  
TOMOAKI MORIOKA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Diabetic Kidney Disease ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Diabetic Kidney

539-P: The Trend of Diabetic Kidney Disease with Low eGFR and Absence of Albuminuria in Type 2 Diabetic Patients in Japan from 1996-2015

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 539-P
Author(s):  
YOSHINORI KAKUTANI ◽  
MASANORI EMOTO ◽  
KATSUHITO MORI ◽  
YUKO YAMAZAKI ◽  
AKINOBU OCHI ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetic Kidney ◽  
Type 2 Diabetic
Sign in / Sign up

Export Citation Format

Share Document