scholarly journals The 2B subdomain of Rep helicase links translocation along DNA with protein displacement

2018 ◽  
Vol 46 (17) ◽  
pp. 8917-8925 ◽  
Author(s):  
Jan-Gert Brüning ◽  
Jamieson A L Howard ◽  
Kamila K Myka ◽  
Mark S Dillingham ◽  
Peter McGlynn
Keyword(s):  
Protein Displacement

Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement

2013 ◽  
Vol 125 (48) ◽  
pp. 12819-12823 ◽  
Author(s):  
Helene Launay ◽  
Benjamin Parent ◽  
Adeline Page ◽  
Xavier Hanoulle ◽  
Guy Lippens
Keyword(s):  
Binary Complex ◽  
Dissociation Kinetics ◽  
Kinetics Of ◽  
Protein Displacement

An Interaction Between Aspirin and Valproate: The Relevance of Plasma Protein Displacement Drug-Drug Interactions

2006 ◽  
Vol 163 (11) ◽  
pp. 1891-1896 ◽  
Author(s):  
Neil B. Sandson ◽  
Catherine Marcucci ◽  
Denis L. Bourke ◽  
Rosemary Smith-Lamacchia
Keyword(s):  
Drug Interactions ◽  
Plasma Protein ◽  
Protein Displacement

The effect of surfactant type on protein displacement from the air–water interface

2004 ◽  
Vol 18 (3) ◽  
pp. 509-515 ◽  
Author(s):  
P.A. Gunning ◽  
A.R. Mackie ◽  
A.P. Gunning ◽  
P.J. Wilde ◽  
N.C. Woodward ◽  
...  
Keyword(s):  
Water Interface ◽  
Air Water Interface ◽  
Protein Displacement

Antiretroviral concentrations in the presence and absence of valproic acid

2020 ◽  
Vol 75 (7) ◽  
pp. 1969-1971
Author(s):  
A Calcagno ◽  
J Cusato ◽  
M Ferrara ◽  
A De Nicolò ◽  
A Lazzaro ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Drug Interaction ◽  
Plasma Concentrations ◽  
Integrase Inhibitor ◽  
Major Effect ◽  
Therapeutic Drug ◽  
Hiv Integrase ◽  
Drug Drug Interaction ◽  
Underlying Mechanisms ◽  
Protein Displacement

Abstract Objectives An unexpected drug–drug interaction has been recently reported between dolutegravir, an HIV integrase inhibitor, and valproic acid. Despite there being several potential underlying mechanisms, plasma protein displacement has been suggested. The aim of this study was to assess plasma concentrations of several antiretrovirals when administered with or without valproic acid. Methods We performed a therapeutic drug monitoring registry analysis and identified patients concomitantly taking antiretrovirals and valproic acid and without clinical affecting conditions or interacting drugs. Results One hundred and thirty-four patients were identified. Median (IQR) age and BMI were 49.7 years (45–56) and 23.4 kg/m2 (20.8–26.3) and 78 were male (58.2%). Despite small groups, we observed no major effect on antiretroviral exposure, even when considering highly protein-bound compounds (such as etravirine), with the exception of dolutegravir trough concentrations [median (IQR) = 132 ng/mL (62–227) in individuals on valproic acid versus 760 ng/mL (333–1407) in those not receiving valproic acid]. Conclusions Valproic acid does not have a major effect on antiretrovirals other than dolutegravir. The mechanism of this unexpected drug–drug interaction may be the combination of protein displacement, reduced absorption and CYP3A4 induction.

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