scholarly journals The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability

2018 ◽  
Vol 46 (5) ◽  
pp. 2459-2478 ◽  
Author(s):  
David Dilworth ◽  
Geoff Gudavicius ◽  
Xiaoxue Xu ◽  
Andrew K J Boyce ◽  
Connor O’Sullivan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Genomic Stability ◽  
Prolyl Isomerase ◽  
Cycle Progression ◽  
Microtubule Polymerization

Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells

2017 ◽  
Vol 213 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Prabodh Risal ◽  
Nirajan Shrestha ◽  
Lokendra Chand ◽  
Karl G. Sylvester ◽  
Yeon Jun Jeong
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Oval Cells ◽  
Prolyl Isomerase ◽  
Cycle Progression ◽  
Hepatic Oval Cells

scholarly journals Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

2008 ◽  
Vol 181 (1) ◽  
pp. 65-78 ◽  
Author(s):  
Akiko Seki ◽  
Judith A. Coppinger ◽  
Haining Du ◽  
Chang-Young Jang ◽  
John R. Yates ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mitotic Progression ◽  
Cell Cycle Protein ◽  
Cycle Progression ◽  
Microtubule Polymerization ◽  
Anaphase Onset ◽  
Chromatid Segregation ◽  
Spindle Stability ◽  
Synthesis And Degradation

Through a convergence of functional genomic and proteomic studies, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase and the SCF–β-TrCP ubiquitin ligase. We show that the Bora protein peaks in G2 and is degraded by proteasomes in mitosis. Proteolysis of Bora requires the Plk1 kinase activity and is mediated by SCF–β-TrCP. Plk1 phosphorylates a conserved DSGxxT degron in Bora and promotes its interaction with β-TrCP. Mutations in this degron stabilize Bora. Expression of a nondegradable Bora variant prolongs the metaphase and delays anaphase onset, indicating a physiological requirement of Bora degradation. Interestingly, the activity of Bora is also required for normal mitotic progression, as knockdown of Bora activates the spindle checkpoint and delays sister chromatid segregation. Mechanistically, Bora regulates spindle stability and microtubule polymerization and promotes tension across sister kinetochores during mitosis. We conclude that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression.

scholarly journals Polyphosphate is involved in cell cycle progression and genomic stability inSaccharomyces cerevisiae

2016 ◽  
Vol 101 (3) ◽  
pp. 367-380 ◽  
Author(s):  
Samuel Bru ◽  
Joan Marc Martínez-Laínez ◽  
Sara Hernández-Ortega ◽  
Eva Quandt ◽  
Javier Torres-Torronteras ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Genomic Stability ◽  
Cycle Progression

scholarly journals The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability

Cell Reports ◽  
2016 ◽  
Vol 15 (4) ◽  
pp. 724-734 ◽  
Author(s):  
Teresa L.F. Ho ◽  
Guillaume Guilbaud ◽  
J. Julian Blow ◽  
Julian E. Sale ◽  
Christine J. Watson
Keyword(s):  
Cell Cycle ◽  
Zinc Finger ◽  
Cell Cycle Progression ◽  
Zinc Finger Protein ◽  
Genomic Stability ◽  
Cycle Progression ◽  
Finger Protein

scholarly journals TRIP-Br Links E2F to Novel Functions in the Regulation of Cyclin E Expression During Cell Cycle Progression and in the Maintenance of Genomic Stability

Cell Cycle ◽  
2004 ◽  
Vol 3 (10) ◽  
pp. 1296-1304 ◽  
Author(s):  
Khe Guan Sim ◽  
Zhijiang Zang ◽  
Christopher Maolin Yang ◽  
Joseph V. Bonventre ◽  
Stephen I-Hong Hsu
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cyclin E ◽  
Genomic Stability ◽  
Cycle Progression

The Aspergillus nidulans hfa mutations affect genomic stability and cause diverse defects in cell cycle progression and cellular morphogenesis

2000 ◽  
Vol 104 (12) ◽  
pp. 1439-1448 ◽  
Author(s):  
Michelle A. Hughes ◽  
Deborah A. Barnett ◽  
Zainon Mohd-Noor ◽  
Susan L. Whittaker ◽  
John H. Doonan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Aspergillus Nidulans ◽  
Cell Cycle Progression ◽  
Genomic Stability ◽  
Cycle Progression ◽  
Cellular Morphogenesis

scholarly journals Safeguarding Entry into Mitosis: the Antephase Checkpoint

2009 ◽  
Vol 30 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Cheen Fei Chin ◽  
Foong May Yeong
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Progression ◽  
Genomic Stability ◽  
Genomic Integrity ◽  
Cycle Progression ◽  
Spatial Coordination ◽  
Spindle Assembly Checkpoints ◽  
The Status ◽  
Temporal And Spatial

ABSTRACT Maintenance of genomic stability is needed for cells to survive many rounds of division throughout their lifetime. Key to the proper inheritance of intact genome is the tight temporal and spatial coordination of cell cycle events. Moreover, checkpoints are present that function to monitor the proper execution of cell cycle processes. For instance, the DNA damage and spindle assembly checkpoints ensure genomic integrity by delaying cell cycle progression in the presence of DNA or spindle damage, respectively. A checkpoint that has recently been gaining attention is the antephase checkpoint that acts to prevent cells from entering mitosis in response to a range of stress agents. We review here what is known about the pathway that monitors the status of the cells at the brink of entry into mitosis when cells are exposed to insults that threaten the proper inheritance of chromosomes. We highlight issues which are unresolved in terms of our understanding of the antephase checkpoint and provide some perspectives on what lies ahead in the understanding of how the checkpoint functions.

Sign in / Sign up

Export Citation Format

Share Document