scholarly journals Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA

2016 ◽  
Vol 44 (6) ◽  
pp. 2898-2908 ◽  
Author(s):  
Xinying Zong ◽  
Shinichi Nakagawa ◽  
Susan M. Freier ◽  
Jingyi Fei ◽  
Taekjip Ha ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Natural Antisense Rna

A long natural-antisense RNA is accumulated in the conidia ofAspergillus oryzae

2015 ◽  
Vol 80 (2) ◽  
pp. 386-398 ◽  
Author(s):  
Masaru Tsujii ◽  
Satoshi Okuda ◽  
Kazutomo Ishi ◽  
Kana Madokoro ◽  
Michio Takeuchi ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Natural Antisense Rna

Ribozymes expressed within the loop of a natural antisense RNA form functional transcription terminators

Gene ◽  
1995 ◽  
Vol 155 (1) ◽  
pp. 35-43 ◽  
Author(s):  
James O. Deshler ◽  
Haitang Li ◽  
John J. Rossi ◽  
Daniela Castanotto
Keyword(s):  
Antisense Rna ◽  
Natural Antisense Rna

scholarly journals Circadian clocks and natural antisense RNA

FEBS Letters ◽  
2004 ◽  
Vol 567 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Susan K. Crosthwaite
Keyword(s):  
Antisense Rna ◽  
Circadian Clocks ◽  
Natural Antisense Rna

Function Of Natural Antisense RNA In Coordinating Myosin Heavy Chain Gene Switching In Skeletal Muscle

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S245???S246 ◽  
Author(s):  
Clay E. Pandorf ◽  
Faddia Haddad ◽  
Roland R. Roy ◽  
Anqi X. Qin ◽  
V. Reggie Edgerton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Antisense Rna ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Natural Antisense Rna ◽  
Gene Switching

scholarly journals The temporal expression profile of a Nos3-related natural antisense RNA in the brain suggests a possible role in neurogenesis

Nitric Oxide ◽  
2017 ◽  
Vol 71 ◽  
pp. 27-31
Author(s):  
Gabriela G. Chavez ◽  
Gabriella Taylor ◽  
Jekaterina Garaliene ◽  
Guy P. Richardson ◽  
Sergei A. Korneev
Keyword(s):  
Expression Profile ◽  
Antisense Rna ◽  
Temporal Expression ◽  
Temporal Expression Profile ◽  
Natural Antisense Rna ◽  
The Brain

scholarly journals The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell

2011 ◽  
Vol 286 (22) ◽  
pp. 19523-19532 ◽  
Author(s):  
Daryn R. Michael ◽  
Aled O. Phillips ◽  
Aleksandra Krupa ◽  
John Martin ◽  
James E. Redman ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Tubular Epithelial Cell ◽  
Hyaluronan Synthase ◽  
Natural Antisense Rna ◽  
Proximal Tubular ◽  
Renal Proximal Tubular ◽  
Hyaluronan Synthase 2 ◽  
Transcriptional Induction ◽  
Tgf Β1

Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension, osteoarthritis, asthma, thyroid dysfunction, and large organ fibrosis. Renal fibrosis is associated with increased cortical synthesis of hyaluronan (HA), an extracellular matrix glycosaminoglycan, and we have shown that HA is a correlate of interstitial fibrosis in vivo. Our previous in vitro data have suggested that both HAS2 transcriptional induction and subsequent HAS2-driven HA synthesis may contribute to kidney fibrosis via phenotypic modulation of the renal proximal tubular epithelial cell (PTC). Post-transcriptional regulation of HAS2 mRNA synthesis by the natural antisense RNA HAS2-AS1 has recently been described in osteosarcoma cells, but the antisense transcript was not detected in kidney. In this study, PTC stimulation with IL-1β or TGF-β1 induced coordinated temporal profiles of HAS2-AS1 and HAS2 transcription. Constitutive activity of the putative HAS2-AS1 promoter was demonstrated, and transcription factor-binding sequence motifs were identified. Knockdown of Sp1/Sp3 expression by siRNA blunted IL-1β induction of both HAS2-AS1 and HAS2, and Smad2/Smad3 knockdown similarly attenuated TGF-β1 stimulation. Inhibition of IL-1β-stimulated HAS2-AS1 RNA induction using HAS2-AS1-specific siRNAs also suppressed up-regulation of HAS2 mRNA transcription. The thermodynamic feasibility of HAS2-AS1/HAS2 heterodimer formation was demonstrated in silico, and locus-specific cytoplasmic double-stranded RNA was detected in vitro. In summary, our data show that transcriptional induction of HAS2-AS1 and HAS2 occurs simultaneously in PTCs and suggest that transcription of the antisense RNA stabilizes or augments HAS2 mRNA expression in these cells via RNA/mRNA heteroduplex formation.

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