scholarly journals Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes

2014 ◽  
Vol 42 (13) ◽  
pp. 8719-8731 ◽  
Author(s):  
Xiao-Xi Huang ◽  
Li-Na Zhu ◽  
Bin Wu ◽  
Yan-Fang Huo ◽  
Na-Na Duan ◽  
...  
Keyword(s):  
Cationic Porphyrin ◽  
Recognition Specificity ◽  
G Quadruplex

A water-soluble cationic porphyrin showing pH-dependent G-quadruplex recognition specificity and DNA photocleavage activity

RSC Advances ◽  
2015 ◽  
Vol 5 (59) ◽  
pp. 47709-47717 ◽  
Author(s):  
Ting Zhao ◽  
Ya-Ling Wang ◽  
Li-Na Zhu ◽  
Yan-Fang Huo ◽  
Yong-Jian Wang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Duplex Dna ◽  
Dna Photocleavage ◽  
Cationic Porphyrin ◽  
Recognition Specificity ◽  
G Quadruplex ◽  
Ph Dependent

A new water-soluble cationic porphyrin was synthesized. It shows pH-dependent G-quadruplex recognition specificity against duplex DNA, pH-dependent photocleavage activity towards duplex DNA and pH-dependent phototoxicity to cells.

scholarly journals Effects of deficient of the Hoogsteen base-pairs on the G-quadruplex stabilization and binding mode of a cationic porphyrin

2015 ◽  
Vol 2 ◽  
pp. 29-35 ◽  
Author(s):  
Jihye Moon ◽  
Ji Hoon Han ◽  
Da Young Kim ◽  
Maeng-joon Jung ◽  
Seog K. Kim
Keyword(s):  
Binding Mode ◽  
Base Pairs ◽  
Cationic Porphyrin ◽  
G Quadruplex

Asymmetric Cationic Porphyrin as a New G-Quadruplex Probe with Wash-Free Cancer-Targeted Imaging Ability Under Acidic Microenvironments

2018 ◽  
Vol 10 (16) ◽  
pp. 13350-13360 ◽  
Author(s):  
Ran Zhang ◽  
Meng Cheng ◽  
Li-Ming Zhang ◽  
Li-Na Zhu ◽  
De-Ming Kong
Keyword(s):  
Targeted Imaging ◽  
Cationic Porphyrin ◽  
G Quadruplex

Spectroscopic study on the binding of a cationic porphyrin to DNA G-quadruplex under different K+ concentrations

2008 ◽  
Vol 7 (8) ◽  
pp. 948 ◽  
Author(s):  
Hui-Juan Zhang ◽  
Xue-Fei Wang ◽  
Peng Wang ◽  
Xi-Cheng Ai ◽  
Jian-Ping Zhang
Keyword(s):  
Spectroscopic Study ◽  
Cationic Porphyrin ◽  
G Quadruplex

scholarly journals Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1173
Author(s):  
Judit Somkuti ◽  
Orsolya Réka Molnár ◽  
Anna Grád ◽  
László Smeller
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Pressure Perturbation ◽  
Viral Nucleic Acid ◽  
Cationic Porphyrin ◽  
G Quadruplex ◽  
Human Telomere ◽  
Temperature And Pressure ◽  
The Stability ◽  
Nucleic Acid Structures

G-quadruplexes are noncanonical structures formed by guanine-rich sequences of the genome. They are found in crucial loci of the human genome, they take part in the regulation of important processes like cell proliferation and cell death. Much less is known about the subjects of this work, the viral G-quadruplexes. We have chosen three potentially G-quadruplex-forming sequences of hepatitis B. We measured the stability and the thermodynamic parameters of these quadruplexes. We also investigated the potential stabilization of these G-quadruplexes by binding a special ligand that was originally developed for cancer therapy. Fluorescence and infrared spectroscopic measurements were performed over wide temperature and pressure ranges. Our experiments indicate the small unfolding volume change of all three oligos. We found a difference between the unfolding of the 2-quartet and the 3-quartet G-quadruplexes. All three G-quadruplexes were stabilized by TMPyP4, which is a cationic porphyrin developed for stabilizing the human telomere.

Water soluble cationic porphyrin TMPipEOPP-induced G-quadruplex and double-stranded DNA photocleavage and cell phototoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13080-13087 ◽  
Author(s):  
Li-Na Zhu ◽  
Shan Shi ◽  
Lin Yang ◽  
Min Zhang ◽  
Ke-Ke Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Dna Photocleavage ◽  
Cationic Porphyrin ◽  
Porphyrin Derivative ◽  
Double Stranded Dna ◽  
G Quadruplex ◽  
Human Telomere

A water soluble cationic porphyrin derivative TMPipEOPP can preferentially photocleave G-quadruplex in the presence of ​double-stranded DNA, thus might be used as a human telomere-targeted photosensitizer for tumor photodynamic therapy.

Conformational conversion of DNA G-quadruplex induced by a cationic porphyrin

2009 ◽  
Vol 74 (1) ◽  
pp. 243-247 ◽  
Author(s):  
Huijuan Zhang ◽  
Xiao Xiao ◽  
Peng Wang ◽  
Siping Pang ◽  
Feng Qu ◽  
...  
Keyword(s):  
Cationic Porphyrin ◽  
G Quadruplex ◽  
Conformational Conversion
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