scholarly journals Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells

2013 ◽  
Vol 41 (22) ◽  
pp. 10228-10240 ◽  
Author(s):  
Chun-Fui Lai ◽  
Koen D. Flach ◽  
Xanthippi Alexi ◽  
Stephen P. Fox ◽  
Silvia Ottaviani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Oestrogen Receptor Α ◽  
Regulated Gene Expression

Xenoestrogens and the induction of proliferative effects in breast cancer cells via direct activation of oestrogen receptor α

2004 ◽  
Vol 21 (2) ◽  
pp. 134-144 ◽  
Author(s):  
A. G. Recchia ◽  
A. Vivacqua ◽  
S. Gabriele ◽  
A. Carpino ◽  
G. Fasanella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Direct Activation ◽  
Oestrogen Receptor Α

scholarly journals Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells

2020 ◽  
Vol 511 ◽  
pp. 110859 ◽  
Author(s):  
Sean M. Holloran ◽  
Bakhtiyor Nosirov ◽  
Katherine R. Walter ◽  
Gloria M. Trinca ◽  
Zhao Lai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Fine Tuning ◽  
Regulated Gene Expression

Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen

2014 ◽  
Vol 465 (1) ◽  
pp. 49-61 ◽  
Author(s):  
Brandie N. Radde ◽  
Margarita M. Ivanova ◽  
Huy Xuan Mai ◽  
Joshua K. Salabei ◽  
Bradford G. Hill ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Real Time ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Flux Analysis ◽  
Intact Cells ◽  
Extracellular Flux ◽  
Oestrogen Receptor Α ◽  
Mcf 7

Oestrogen receptor α-expressing breast cancer cells show differences in basal bioenergetics profiles and bioenergetics responses to serum depletion, oestradiol and tamoxifen as measured in real time by extracellular flux analysis in intact cells.

scholarly journals Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
María F Montenegro ◽  
María del Mar Collado-González ◽  
María Piedad Fernández-Pérez ◽  
Manel B Hammouda ◽  
Lana Tolordava ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Oestrogen Receptor Α

scholarly journals Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells

2003 ◽  
Vol 179 (1) ◽  
pp. 41-53 ◽  
Author(s):  
R Margueron ◽  
A Licznar ◽  
G Lazennec ◽  
F Vignon ◽  
V Cavailles
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
P21 Waf1

We analysed the antiproliferative activity of various histone deacetylase (HDAC) inhibitors such as trichostatin A (TSA) on human breast cancer cells. We observed a lower sensitivity to HDAC inhibition for oestrogen receptor negative (ER-) versus positive (ER+) cell lines. This differential response was associated neither with a modification of drug efflux via the multidrug resistance system nor with a global modification of histone acetyltransferase (HAT)/HDAC activities. In contrast, we demonstrated that in ER+ breast cancer cells the p21(WAF1/CIP1) gene was more sensitive to TSA regulation and was expressed at higher levels. These differences were observed both in transient transfection experiments and on the endogenous p21(WAF1/CIP1) gene. The Sp1 transcription factor, which was shown to interact in vitro with both class I and class II HDACs, is sufficient to confer the differential sensitivity to TSA and participated in the control of p21(WAF1/CIP1) basal expression. Finally, re-expression of ERalpha following adenoviral infection of ER- breast cancer cells increased both p21(WAF1/CIP1) protein accumulation and the growth inhibitory activity of TSA. Altogether, our results highlight the key role of ERalpha and p21(WAF1/CIP1) gene expression in the sensitivity of breast cancer cells to hyperacetylating agents.

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