scholarly journals The major form of hepatitis C virus alternate reading frame protein is suppressed by core protein expression

2008 ◽  
Vol 36 (9) ◽  
pp. 3054-3064 ◽  
Author(s):  
M. Wolf ◽  
M. Dimitrova ◽  
T. F. Baumert ◽  
C. Schuster
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Expression ◽  
Core Protein ◽  
Reading Frame ◽  
Alternate Reading Frame Protein ◽  
Major Form

Recombinant expression of the alternate reading frame protein (ARFP) of hepatitis C virus genotype 4a (HCV-4a) and detection of ARFP and anti-ARFP antibodies in HCV-infected patients

2015 ◽  
Vol 160 (8) ◽  
pp. 1939-1952 ◽  
Author(s):  
Michael G. Shehat ◽  
Mohammed Bahey-El-Din ◽  
Mervat A. Kassem ◽  
Faten A. Farghaly ◽  
Medhat H. Abdul-Rahman ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Recombinant Expression ◽  
Virus Genotype ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

scholarly journals Expression of alternate reading frame protein (F1) of hepatitis C virus in Escherichia coli and detection of antibodies for F1 in Indian patients

2008 ◽  
Vol 8 (3) ◽  
pp. 374-377 ◽  
Author(s):  
Munpally Shesheer Kumar ◽  
Khareedu Venkateswara Rao ◽  
Chittor Mohammed Habeebullah ◽  
Vudem Dashavantha Reddy
Keyword(s):  
Escherichia Coli ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Reading Frame ◽  
Alternate Reading Frame Protein ◽  
Indian Patients

scholarly journals Seroconversion to hepatitis C virus alternate reading frame protein during acute infection

Hepatology ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 1449-1459 ◽  
Author(s):  
Yoann Morice ◽  
Maxime Ratinier ◽  
Ahmed Miladi ◽  
Stéphane Chevaliez ◽  
Georgios Germanidis ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Infection ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression

Inflammation ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 1823-1834 ◽  
Author(s):  
Dan Yan Zhu ◽  
Xiao Zhao Deng ◽  
Long Feng Jiang ◽  
Wen Xiao ◽  
Jia Ping Pei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Potential Role ◽  
Negative Regulation ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

scholarly journals Suppression Of Hepatitis C Virus Core Protein By Short Hairpin Rna Expression Vectors In The Core Protein Expression Huh-7 Cells

2007 ◽  
Vol 26 (6-7) ◽  
pp. 815-820 ◽  
Author(s):  
Hitoshi Suzuki ◽  
Hiroyasu Kaneko ◽  
Nobushige Tamai ◽  
Kunitada Shimotohno ◽  
Naoko Miyano-Kurosaki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Expression ◽  
Core Protein ◽  
Expression Vectors ◽  
Rna Expression ◽  
Hairpin Rna ◽  
The Core ◽  
Virus Core ◽  
Short Hairpin

scholarly journals Functional properties of a 16 kDa protein translated from an alternative open reading frame of the core-encoding genomic region of hepatitis C virus

2004 ◽  
Vol 85 (8) ◽  
pp. 2299-2306 ◽  
Author(s):  
Arnab Basu ◽  
Robert Steele ◽  
Ranjit Ray ◽  
Ratna B. Ray
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Genomic Region ◽  
Open Reading Frame ◽  
Transcriptional Level ◽  
Reading Frame ◽  
F Protein ◽  
Hcv Core Protein ◽  
Core Proteins

Hepatitis C virus (HCV) often causes persistent infection in humans. This could be due in part to the effect of viral proteins on cellular gene expression. Earlier observations suggest that the HCV core protein expressed from genotype 1a modulates important cellular genes at the transcriptional level, affects programmed cell death (apoptosis) and promotes cell growth. Recently, different groups of investigators have reported the translation of an ∼16 kDa protein (named F/ARFP/core+1 ORF) from an alternate open reading frame of the HCV core-encoding genomic region. The functional significance of this F protein is presently unknown. Thus, whether the F and core proteins have both shared and distinct functions was investigated here. The experimental observations suggested that the F protein does not significantly modulate c-myc, hTERT and p53 promoter activities, unlike the HCV core protein. Interestingly, the F protein repressed p21 expression. Further studies indicated that the F protein does not inhibit tumour necrosis factor alpha-mediated apoptosis of HepG2 cells or promote rat embryo fibroblast growth. Taken together, these results suggest that the F protein does not share major properties identified previously for the HCV core protein, other than regulating p21 expression.

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