scholarly journals Seroconversion to hepatitis C virus alternate reading frame protein during acute infection

Hepatology ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 1449-1459 ◽  
Author(s):  
Yoann Morice ◽  
Maxime Ratinier ◽  
Ahmed Miladi ◽  
Stéphane Chevaliez ◽  
Georgios Germanidis ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Infection ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

Recombinant expression of the alternate reading frame protein (ARFP) of hepatitis C virus genotype 4a (HCV-4a) and detection of ARFP and anti-ARFP antibodies in HCV-infected patients

2015 ◽  
Vol 160 (8) ◽  
pp. 1939-1952 ◽  
Author(s):  
Michael G. Shehat ◽  
Mohammed Bahey-El-Din ◽  
Mervat A. Kassem ◽  
Faten A. Farghaly ◽  
Medhat H. Abdul-Rahman ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Recombinant Expression ◽  
Virus Genotype ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

scholarly journals Expression of alternate reading frame protein (F1) of hepatitis C virus in Escherichia coli and detection of antibodies for F1 in Indian patients

2008 ◽  
Vol 8 (3) ◽  
pp. 374-377 ◽  
Author(s):  
Munpally Shesheer Kumar ◽  
Khareedu Venkateswara Rao ◽  
Chittor Mohammed Habeebullah ◽  
Vudem Dashavantha Reddy
Keyword(s):  
Escherichia Coli ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Reading Frame ◽  
Alternate Reading Frame Protein ◽  
Indian Patients

Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression

Inflammation ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 1823-1834 ◽  
Author(s):  
Dan Yan Zhu ◽  
Xiao Zhao Deng ◽  
Long Feng Jiang ◽  
Wen Xiao ◽  
Jia Ping Pei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Potential Role ◽  
Negative Regulation ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

scholarly journals Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 ◽  
Vol 191 (9) ◽  
pp. 1499-1512 ◽  
Author(s):  
Franziska Lechner ◽  
David K.H. Wong ◽  
P. Rod Dunbar ◽  
Roger Chapman ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Acute Infection ◽  
Hcv Infection ◽  
Ctl Response ◽  
Acute Hcv ◽  
Ifn Γ ◽  
Acute Hcv Infection

Although hepatitis C virus (HCV) infection is very common, identification of patients during acute infection is rare. Consequently, little is known about the immune response during this critical stage of the disease. We analyzed the T lymphocyte response during and after acute resolving HCV infection in three persons, using interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) and human histocompatibility leukocyte antigen (HLA) peptide tetramer assays. Acute infection was associated with a broadly directed T helper and cytotoxic T lymphocyte (CTL) response, which persisted after resolution of clinical hepatitis and clearance of viremia. At the earliest time point studied, highly activated CTL populations were observed that temporarily failed to secrete IFN-γ, a “stunned” phenotype, from which they recovered as viremia declined. In long-term HCV-seropositive persons, CTL responses were more common in persons who had cleared viremia compared with those with persistent viremia, although the frequencies of HCV-specific CTLs were lower than those found in persons during and after resolution of acute HCV infection. These studies demonstrate a strong and persistent CTL response in resolving acute HCV infection, and provide rationale to explore immune augmentation as a therapeutic intervention in chronic HCV infection.

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