scholarly journals Kinetic analysis of the role of the tyrosine 13, phenylalanine 56 and glutamine 54 network in the U1A/U1 hairpin II interaction

2005 ◽  
Vol 33 (9) ◽  
pp. 2917-2928 ◽  
Author(s):  
M. J. Law
2019 ◽  
Vol 377 ◽  
pp. 120143
Author(s):  
Sunil K. Rawat ◽  
Vaibhav Srivastava ◽  
Divesh Bhatia

2001 ◽  
Vol 75 (11) ◽  
pp. 4984-4989 ◽  
Author(s):  
Simon K. Tsang ◽  
Brian M. McDermott ◽  
Vincent R. Racaniello ◽  
James M. Hogle

ABSTRACT We examined the role of soluble poliovirus receptor on the transition of native poliovirus (160S or N particle) to an infectious intermediate (135S or A particle). The viral receptor behaves as a classic transition state theory catalyst, facilitating the N-to-A conversion by lowering the activation energy for the process by 50 kcal/mol. In contrast to earlier studies which demonstrated that capsid-binding drugs inhibit thermally mediated N-to-A conversion through entropic stabilization alone, capsid-binding drugs are shown to inhibit receptor-mediated N-to-A conversion through a combination of enthalpic and entropic effects.


ACS Catalysis ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 4326-4336 ◽  
Author(s):  
Joy S. Zeng ◽  
Nathan Corbin ◽  
Kindle Williams ◽  
Karthish Manthiram

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