Evidence for the functional role of residues in the B′–C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling

Karl-Heinz Storbeck; Pieter Swart; Sandra Graham; Amanda C. Swart

doi:10.1016/j.jsbmb.2006.07.003

Evidence for the functional role of residues in the B′–C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2006.07.003 ◽

2007 ◽

Vol 103 (1) ◽

pp. 65-75 ◽

Cited By ~ 1

Author(s):

Karl-Heinz Storbeck ◽

Pieter Swart ◽

Sandra Graham ◽

Amanda C. Swart

Keyword(s):

Cytochrome P450 ◽

Kinetic Analysis ◽

Functional Role ◽

Homology Modelling ◽

Site Directed Mutagenesis ◽

Side Chain ◽

Directed Mutagenesis ◽

Side Chain Cleavage ◽

Chain Cleavage

Download Full-text

Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)50028-4 ◽

1992 ◽

Vol 267 (32) ◽

pp. 22877-22882 ◽

Cited By ~ 1

Author(s):

A Wada ◽

M.R. Waterman

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Side Chain ◽

Directed Mutagenesis ◽

Side Chain Cleavage ◽

Chain Cleavage ◽

Lysine Residues

Download Full-text

Role of luteinizing hormone in the expression of cholesterol side-chain cleavage cytochrome P450 and 3 beta-hydroxysteroid dehydrogenase, delta 5-4 isomerase messenger ribonucleic acids in the primate corpus luteum.

Endocrinology ◽

10.1210/endo.131.5.1425410 ◽

1992 ◽

Vol 131 (5) ◽

pp. 2065-2070 ◽

Cited By ~ 22

Author(s):

N Ravindranath ◽

L Little-Ihrig ◽

D F Benyo ◽

A J Zeleznik

Keyword(s):

Cytochrome P450 ◽

Luteinizing Hormone ◽

Corpus Luteum ◽

Hydroxysteroid Dehydrogenase ◽

Side Chain ◽

Ribonucleic Acids ◽

Side Chain Cleavage ◽

Chain Cleavage

Download Full-text

Role of Steroidogenic-Factor 1 in Basal and 3′,5′-Cyclic Adenosine Monophosphate-Mediated Regulation of Cytochrome P450 Side-Chain Cleavage Enzyme in the Mouse1

Biology of Reproduction ◽

10.1095/biolreprod57.4.765 ◽

1997 ◽

Vol 57 (4) ◽

pp. 765-771 ◽

Cited By ~ 39

Author(s):

Yuen M. Chau ◽

Peter A. Crawford ◽

Karen G. Woodson ◽

Jeffrey A. Polish ◽

Lisa M. Olson ◽

...

Keyword(s):

Cytochrome P450 ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Side Chain ◽

Steroidogenic Factor 1 ◽

Side Chain Cleavage ◽

Chain Cleavage ◽

Cleavage Enzyme

Download Full-text

Transcription of Cholesterol Side-Chain Cleavage Cytochrome P450 in the Placenta: Activating Protein-2 Assumes the Role of Steroidogenic Factor-1 by Binding to an Overlapping Promoter Element

Molecular Endocrinology ◽

10.1210/me.2002-0056 ◽

2002 ◽

Vol 16 (8) ◽

pp. 1864-1880 ◽

Cited By ~ 31

Author(s):

Micha Ben-Zimra ◽

Moriah Koler ◽

Joseph Orly

Keyword(s):

Cytochrome P450 ◽

Side Chain ◽

Promoter Element ◽

Steroidogenic Factor 1 ◽

Side Chain Cleavage ◽

Chain Cleavage

Download Full-text

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

Download Full-text

The role of mitochondrial cytochrome P-450 from bovine adrenal cortex in side chain cleavage of 20S,22R-dihydroxycholesterol.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)41712-2 ◽

1975 ◽

Vol 250 (6) ◽

pp. 2283-2286

Author(s):

PF Hall ◽

JL Lewes ◽

ED Lipson

Keyword(s):

Adrenal Cortex ◽

Side Chain ◽

Mitochondrial Cytochrome ◽

Side Chain Cleavage ◽

Chain Cleavage ◽

Cytochrome P 450

Download Full-text

Determination of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase by site-directed mutagenesis

Zurich, Switzerland, September 3–8, 1989 ◽

10.1515/9783110889000-148 ◽

1990 ◽

pp. 765-768

Keyword(s):

Dihydrofolate Reductase ◽

Functional Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Human Dihydrofolate Reductase

Download Full-text

Nitrate reductase of Neurospora crassa: the functional role of individual amino acids in the heme domain as examined by site-directed mutagenesis

MGG Molecular & General Genetics ◽

10.1007/bf00277060 ◽

1993 ◽

Vol 240 (2) ◽

pp. 221-230 ◽

Cited By ~ 11

Author(s):

Patricia M. Okamoto ◽

George A. Marzluf

Keyword(s):

Amino Acids ◽

Nitrate Reductase ◽

Neurospora Crassa ◽

Functional Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Heme Domain

Download Full-text

Cytochrome P450 side-chain cleavage: Insights gained from homology modeling

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2006.12.005 ◽

2007 ◽

Vol 265-266 ◽

pp. 65-70 ◽

Cited By ~ 17

Author(s):

Karl-Heinz Storbeck ◽

Pieter Swart ◽

Amanda C. Swart

Keyword(s):

Cytochrome P450 ◽

Homology Modeling ◽

Side Chain ◽

Side Chain Cleavage ◽

Chain Cleavage

Download Full-text

Cholesterol Side Chain Cleavage Cytochrome P450 (P450scc)

Cytochrome P450 - Handbook of Experimental Pharmacology ◽

10.1007/978-3-642-77763-9_42 ◽

1993 ◽

pp. 651-665 ◽

Cited By ~ 1

Author(s):

L. E. Vickery

Keyword(s):

Cytochrome P450 ◽

Side Chain ◽

Side Chain Cleavage ◽

Chain Cleavage

Download Full-text