scholarly journals Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae

2003 ◽  
Vol 31 (8) ◽  
pp. 2134-2147 ◽  
Author(s):  
T. D. Read
Keyword(s):  
Genome Sequence ◽  
Chlamydia Psittaci

scholarly journals INFECTIOUS AETIOLOGY OF MARGINAL ZONE LYMPHOMA AND ROLE OF ANTI-INFECTIVE THERAPY

2016 ◽  
Vol 8 ◽  
pp. 2016006 ◽  
Author(s):  
Salvatore Perrone ◽  
Gianna Maria D'Elia ◽  
Alessandro Pulsoni
Keyword(s):  
Malt Lymphoma ◽  
Marginal Zone ◽  
Case Reports ◽  
Lymphocyte Activation ◽  
Chlamydia Psittaci ◽  
Gastric Malt Lymphoma ◽  
First Line Therapy ◽  
Causative Relationship ◽  
Chronic Hcv

Marginal zone lymphomas have been associated with several infectious agents covering both viral and bacterial pathogens and in some cases a clear aetiological role has been established. Pathogenetic mechanisms are currently not completely understood, however the role of chronic stimulation of the host immune response with persistent lymphocyte activation represents the most convincing explanation for lymphoproliferation. Gastric MALT lymphoma is strictly associated with Helicobacter pylori infection and various eradicating protocols, developed due to increasing antibiotic resistance, represent the first line therapy. The response rate to eradication is good with 80% of response at 1 year; this finding is also noteworthy because recapitulates a cancer cured only by antibacterial approach and it satisfies the Koch postulates of causation, establishing a causative relationship between Hp and gastric MALT lymphoma. Patients with chronic HCV infection have 5 times higher risk to develop MZL, in particular an association with splenic and nodal MZL has been shown in several studies. Moreover, there is evidence of lymphoma regression after antiviral therapy with interferon+ribavirin, thus rising hope that new available drugs, extremely effective against HCV replication, could improve outcome also in HCV-driven lymphomas. The rare cases of MZL localized to orbital fat and eye conjunctivas have been associated with Chlamydia psittaci infection carried by birds. Efficacy of antibacterial therapy against C. psittaci are conflicting and generally poorer thain gastric MALT. Finally some case-reports will cover the relationship between primary cutaneous B-cell Lymphomas and Borrelia Burgdorferi.

scholarly journals Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection

2002 ◽  
Vol 70 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Jean-Luc Perfettini ◽  
John C. Reed ◽  
Nicole Israël ◽  
Jean-Claude Martinou ◽  
Alice Dautry-Varsat ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Chlamydia Psittaci ◽  
Host Cells ◽  
Chlamydia Infection ◽  
Caspase Inhibitor ◽  
Obligate Intracellular Bacterium ◽  
Obligate Intracellular ◽  
Infected Cells ◽  
Induced Apoptosis

ABSTRACT Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads to apoptosis of host cells. The apoptosis is not affected by a broad-spectrum caspase inhibitor, and caspase-3 is not activated in infected cells, suggesting that apoptosis mediated by these two strains of Chlamydia is independent of known caspases. Overexpression of the proapoptotic Bcl-2 family member, Bax, was previously shown to induce caspase-independent apoptosis, and we find that Bax is activated and translocates from the cytosol to the mitochondria in C. psittaci-infected cells. C. psittaci-induced apoptosis is inhibited in host cells overexpressing Bax inhibitor-1 and is inhibited through overexpression of Bcl-2, which blocks both caspase-dependent and -independent apoptosis. As Bax and mitochondria are ideally located to sense stress-related metabolic changes emanating from the interior of an infected cell, it is likely that Bax-dependent apoptosis may also be observed in cells infected with other intracellular pathogens.

scholarly journals Draft Genome Sequence of Lawsonibacter asaccharolyticus JCM 32166T, a Butyrate-Producing Bacterium, Isolated from Human Feces

2018 ◽  
Vol 6 (25) ◽  
Author(s):  
Mitsuo Sakamoto ◽  
Nao Ikeyama ◽  
Masahiro Yuki ◽  
Moriya Ohkuma
Keyword(s):  
Genome Sequence ◽  
Draft Genome ◽  
Genomic Analysis ◽  
Draft Genome Sequence ◽  
Human Feces ◽  
Human Gut ◽  
Content Type

Here, we report the draft genome sequence of Lawsonibacter asaccharolyticus JCM 32166T, a butyrate-producing bacterium, isolated from human feces. The genomic analysis reveals genes for butyrate synthesis and will facilitate the study on the role of this strain in the human gut.

scholarly journals The Genome Sequence of the Crenarchaeon Acidilobus saccharovorans Supports a New Order, Acidilobales, and Suggests an Important Ecological Role in Terrestrial Acidic Hot Springs

2010 ◽  
Vol 76 (16) ◽  
pp. 5652-5657 ◽  
Author(s):  
Andrey V. Mardanov ◽  
Vitali A. Svetlitchnyi ◽  
Alexey V. Beletsky ◽  
Maria I. Prokofeva ◽  
Elizaveta A. Bonch-Osmolovskaya ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Hot Springs ◽  
Hot Spring ◽  
Tricarboxylic Acid Cycle ◽  
Proton Translocation ◽  
New Order ◽  
Organic Substrates ◽  
Transfer Chain ◽  
Terrestrial Hot Spring

ABSTRACT Acidilobus saccharovorans is an anaerobic, organotrophic, thermoacidophilic crenarchaeon isolated from a terrestrial hot spring. We report the complete genome sequence of A. saccharovorans, which has permitted the prediction of genes for Embden-Meyerhof and Entner-Doudoroff pathways and genes associated with the oxidative tricarboxylic acid cycle. The electron transfer chain is branched with two sites of proton translocation and is linked to the reduction of elemental sulfur and thiosulfate. The genomic data suggest an important role of the order Acidilobales in thermoacidophilic ecosystems whereby its members can perform a complete oxidation of organic substrates, closing the anaerobic carbon cycle.

scholarly journals On the Neglected Shifting Balance Theory, Bateson-DobzhanskyMuller Model & Quantum Evolution Plus the Role of Mitochondrial Membrane Potential (MMP) Impact on COVID-19

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sorush Niknamian
Keyword(s):  
Genome Sequence ◽  
Ancestral Population ◽  
Quantum Evolution ◽  
Balance Theory ◽  
Ribosomal Frameshift ◽  
Rna Helicases ◽  
Shifting Balance Theory ◽  
Shifting Balance ◽  
Two Populations

Background: Approximately 80% of all viruses are RNA viruses and they contain their specific RNA helicases. Defective RNA helicases have been linked to infectious diseases (Viral Infections). Materials and Methods: The articles have gone through many types of research from the beginning of the epidemic of Coronaviruses through history and we introduced the neglected hypothesis of Shifting balance theory, Bateson-DobzhanskyMuller model & Quantum evolution. In the ancestral population, the genotype is AABB. When two populations become isolated from each other, new mutations can arise. In one population A evolves into a, and in the other B evolves into b. When the two populations hybridize it is the first time A and B interact with each other. When these alleles are incompatible, we speak of Dobzhansky–Muller incompatibilities plus the role of MMA in mitochondria in spreading SARS-CoV-19 through populations and the result of an infection in COVID-19. Results: In viruses specifically COVID-19, Ribosomal Frameshift is programmed to allows the virus to encode multiple types of proteins from the same mRNA. HIV-1 (human immunodeficiency virus), RSV (Rous sarcoma virus), and all types of influenza viruses use Ribosomal Frameshift. They rely on frameshifting to create a proper ratio of normal translation and trans-frame (encoded by frameshifted sequence) proteins. Notably, its use in viruses is primarily for compacting more genetic information into a shorter amount of genetic material. Conclusion: to find the genome sequence of COVID-19 we also used Nanopore sequencing that introduced and manufactured by Oxford scientists, due to differences in the action of infection in the host, we could not reach any results since the Novel Virus has not a stable genome (which is quite dynamic) since through our deep research, each virus contains its specific genome sequencing and we cannot claim that COVID-19 has one specific genome sequence like MERS-CoV, SARS-CoV or any types of viruses which has been discovered and contains their specific genome.

scholarly journals Draft Genome Sequence of Raoultella ornithinolytica P079F W, Isolated from the Feces of a Preterm Infant

2019 ◽  
Vol 8 (33) ◽  
Author(s):  
Yuhao Chen ◽  
Thomas C. Brook ◽  
Cristina Alcon-Giner ◽  
Paul Clarke ◽  
Lindsay J. Hall ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Gut Microbiota ◽  
Genome Sequence ◽  
Neonatal Intensive Care ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Neonatal Infections ◽  
Content Type

Here, we describe the draft genome sequence of Raoultella ornithinolytica P079F W, isolated from the feces of an infant residing in a neonatal intensive care unit during an ongoing study to characterize the neonate gut microbiota. P079F W will be used in studies investigating the role of the microbiome in neonatal infections.

Genomics for the Healthy Person

2016 ◽  
Author(s):  
Michael Snyder
Keyword(s):  
Genome Sequence ◽  
Healthy Person

Would knowing your genome affect the disease you might get, the job you choose, the sports you play, and the food you eat? Here we explore the role of knowing your genome sequence if you are healthy.

scholarly journals B-Cell-Deficient Mice Show an Exacerbated Inflammatory Response in a Model of Chlamydophila abortus Infection

2002 ◽  
Vol 70 (12) ◽  
pp. 6911-6918 ◽  
Author(s):  
Antonio J. Buendía ◽  
Laura Del Río ◽  
Nieves Ortega ◽  
Joaquín Sánchez ◽  
María C. Gallego ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cells ◽  
Inflammatory Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Immunoglobulin M ◽  
Chlamydia Psittaci ◽  
Chlamydophila Abortus ◽  
Serotype 1

ABSTRACT The resolution of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection is dependent on gamma interferon and CD8+ T cells, and classically, B cells have been considered to play a minimal role in host defense. The role of B cells in the immune response was studied by using a model of infection in mice with genetically modified immunoglobulin M transmembrane domains (μMT). In the absence of B cells, infection with C. abortus leads to an acute severe fatal disease that involves a disseminated intravascular coagulation syndrome. μMT mice displayed an increased level of proinflammatory cytokines in serum, and an increased number of neutrophils was observed in the lesions. The possible deleterious role of neutrophils in the pathogenesis of disease in μMT mice was determined by depletion of the neutrophils with the monoclonal antibody RB6-8C5. This led to an enhancement of the bacterial burden and early mortality in both μMT and wild-type mice, while necrotic lesions remained. Analysis of the presence of immunoregulatory cytokines showed significantly lower levels of transforming growth factor β in the sera of μMT mice. However, mice lacking mature B cells were able to establish a specific immune response that protected them from a secondary challenge. Taken together, these data suggest an immunomodulatory role for B cells in the early events of C. abortus primary infection that can protect mice against an exaggerated inflammatory response.

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