scholarly journals Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)2

2000 ◽  
Vol 28 (3) ◽  
pp. 728-735 ◽  
Author(s):  
E. Gavathiotis
Keyword(s):  
Minor Groove ◽  
Nmr Structure ◽  
Groove Width ◽  
Solution Nmr ◽  
Hoechst 33258 ◽  
Dna Minor Groove ◽  
Sequence Dependent

Molecular mechanics calculations on the complexes between analogues of Hoechst 33258 and d(CGCGAAT-TCGCG)2: influence of bulky group substitution on base pair preference of DNA minor groove binders

1995 ◽  
Vol 73 (6) ◽  
pp. 878-884 ◽  
Author(s):  
Ding-Kwo Chang ◽  
Shu-Fang Cheng ◽  
Ting-Lin Chien
Keyword(s):  
Molecular Mechanics ◽  
Base Pair ◽  
Minor Groove ◽  
Sequence Specificity ◽  
Hoechst 33258 ◽  
Molecular Mechanics Calculations ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Detailed Structural Analysis ◽  
Groove Binders

Molecular mechanics calculations were performed on the three structures of the complexes formed by the derivatives of Hoechst 33258 and dodecameric DNA duplex d(CGCGAATTCGCG)2. Formation and docking energies of these complexes were compared. It was found that the CG site that is 3′ to the central AATT region can be tolerated by the drugs. This is probably due to the presence of the bulky piperazine ring and, more pronouncedly, by alkylated analogues of the drug that prefer the wider minor groove formed by the GC base pair region of B-DNA. The argument of bulkiness of the piperazine moiety as the origin of enhancement of GC affinity is supported by detailed structural analysis of the intermolecular interface and widening of the DNA minor groove at the binding site. Implications of the results are discussed. Keywords: minor groove binder, docking energy, sequence specificity.

scholarly journals Interaction of DNA Minor Groove Binder Hoechst 33258 with Bovine Serum Albumin

2009 ◽  
Vol 57 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Himanshu Ojha ◽  
Bhaskar Mohan Murari ◽  
Sneh Anand ◽  
Mohd Imtaiyaz Hassan ◽  
Faizan Ahmad ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Hoechst 33258 ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

scholarly journals Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2

1995 ◽  
Vol 23 (18) ◽  
pp. 3678-3684 ◽  
Author(s):  
Alexis A. Wood ◽  
Christine M. Nunn ◽  
Agnieszka Czarny ◽  
David W. Boykin ◽  
Stephen Neidle
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Minor Groove ◽  
Groove Width ◽  
Dna Duplex ◽  
Dna Minor Groove
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