DNA-Directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Minor Groove-Targeted Aniline Mustard Analogs of Pibenzimol (Hoechst 33258)

1994 ◽  
Vol 37 (25) ◽  
pp. 4338-4345 ◽  
Author(s):  
G. Lance Gravatt ◽  
Bruce C. Baguley ◽  
William R. Wilson ◽  
William A. Denny
Keyword(s):  
Antitumor Activity ◽  
Alkylating Agents ◽  
Minor Groove ◽  
Hoechst 33258 ◽  
Dna Minor Groove

DNA Minor Groove Alkylating Agents

2001 ◽  
Vol 8 (5) ◽  
pp. 533-544 ◽  
Author(s):  
William A. Denny
Keyword(s):  
Alkylating Agents ◽  
Minor Groove ◽  
Dna Minor Groove

scholarly journals Hematopoietic toxicity and cell cycle perturbations induced by new DNA minor groove–alkylating agents

1997 ◽  
Vol 72 (5) ◽  
pp. 801-809 ◽  
Author(s):  
Cristian Filippini ◽  
Matteo Bisiach ◽  
Giovanna Tagliabue ◽  
Maurizio D'Incalci ◽  
Paolo Ubezio
Keyword(s):  
Cell Cycle ◽  
Alkylating Agents ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
Hematopoietic Toxicity

Molecular mechanics calculations on the complexes between analogues of Hoechst 33258 and d(CGCGAAT-TCGCG)2: influence of bulky group substitution on base pair preference of DNA minor groove binders

1995 ◽  
Vol 73 (6) ◽  
pp. 878-884 ◽  
Author(s):  
Ding-Kwo Chang ◽  
Shu-Fang Cheng ◽  
Ting-Lin Chien
Keyword(s):  
Molecular Mechanics ◽  
Base Pair ◽  
Minor Groove ◽  
Sequence Specificity ◽  
Hoechst 33258 ◽  
Molecular Mechanics Calculations ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Detailed Structural Analysis ◽  
Groove Binders

Molecular mechanics calculations were performed on the three structures of the complexes formed by the derivatives of Hoechst 33258 and dodecameric DNA duplex d(CGCGAATTCGCG)2. Formation and docking energies of these complexes were compared. It was found that the CG site that is 3′ to the central AATT region can be tolerated by the drugs. This is probably due to the presence of the bulky piperazine ring and, more pronouncedly, by alkylated analogues of the drug that prefer the wider minor groove formed by the GC base pair region of B-DNA. The argument of bulkiness of the piperazine moiety as the origin of enhancement of GC affinity is supported by detailed structural analysis of the intermolecular interface and widening of the DNA minor groove at the binding site. Implications of the results are discussed. Keywords: minor groove binder, docking energy, sequence specificity.

ChemInform Abstract: Heterocyclic Analogues of DNA Minor Groove Alkylating Agents

ChemInform ◽  
2010 ◽  
Vol 29 (35) ◽  
pp. no-no
Author(s):  
P. G. BARALDI ◽  
B. CACCIARI ◽  
A. GUIOTTO ◽  
R. ROMAGNOLI ◽  
A. N. ZAID ◽  
...  
Keyword(s):  
Alkylating Agents ◽  
Minor Groove ◽  
Dna Minor Groove

A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity

2001 ◽  
Vol 44 (2) ◽  
pp. 138-144 ◽  
Author(s):  
John Mann ◽  
Anne Baron ◽  
Yaw Opoku-Boahen ◽  
Eric Johansson ◽  
Gary Parkinson ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
New Class ◽  
Binding Agents

SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

2004 ◽  
Vol 64 (18) ◽  
pp. 6700-6706 ◽  
Author(s):  
Michael C. Alley ◽  
Melinda G. Hollingshead ◽  
Christine M. Pacula-Cox ◽  
William R. Waud ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Broad Spectrum ◽  
Minor Groove ◽  
Cross Linking ◽  
Dna Minor Groove

Distamycin A as Stem of DNA Minor Groove Alkylating Agents

2004 ◽  
Vol 4 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Pier Baraldi ◽  
Maria del Carmen Nunez ◽  
Antonio Espinosa ◽  
Romeo Romagnoli
Keyword(s):  
Alkylating Agents ◽  
Minor Groove ◽  
Distamycin A ◽  
Dna Minor Groove
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