Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles

Mutagenesis ◽  
2016 ◽  
Vol 32 (1) ◽  
pp. 193-202 ◽  
Author(s):  
Alena Gábelová ◽  
Naouale El Yamani ◽  
Tamara Iglesias Alonso ◽  
Barbora Buliaková ◽  
Annamária Srančíková ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Carcinogenic Potential

scholarly journals Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

2018 ◽  
Vol 10 (5) ◽  
pp. 4548-4560 ◽  
Author(s):  
Grazyna Stepien ◽  
María Moros ◽  
Marta Pérez-Hernández ◽  
Marta Monge ◽  
Lucía Gutiérrez ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Effect Of Surface

Role of Surface Chemistry in Mediating the Uptake of Ultrasmall Iron Oxide Nanoparticles by Cancer Cells

2019 ◽  
Vol 11 (19) ◽  
pp. 17157-17166 ◽  
Author(s):  
Akshay A. Narkhede ◽  
Jennifer A. Sherwood ◽  
Angelo Antone ◽  
Kasie R. Coogan ◽  
Mark S. Bolding ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Zwitterion-Coated Iron Oxide Nanoparticles: Surface Chemistry and Intracellular Uptake by Hepatocarcinoma (HepG2) Cells

Langmuir ◽  
2015 ◽  
Vol 31 (26) ◽  
pp. 7381-7390 ◽  
Author(s):  
Sara Mondini ◽  
Marianna Leonzino ◽  
Carmelo Drago ◽  
Anna M. Ferretti ◽  
Sandro Usseglio ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Hepg2 Cells ◽  
Oxide Nanoparticles ◽  
Intracellular Uptake

scholarly journals Bare Iron Oxide Nanoparticles: Surface Tunability for Biomedical, Sensing and Environmental Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1608 ◽  
Author(s):  
Magro ◽  
Vianello
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Environmental Remediation ◽  
Scientific Community ◽  
Food Industry ◽  
Oxide Nanoparticles ◽  
Negative Consequences ◽  
Biomedical Sensing ◽  
Ph Tolerance

Surface modification is widely assumed as a mandatory prerequisite for the real applicability of iron oxide nanoparticles. This is aimed to endow prolonged stability, electrolyte and pH tolerance as well as a desired specific surface chemistry for further functionalization to these materials. Nevertheless, coating processes have negative consequences on the sustainability of nanomaterial production contributing to high costs, heavy environmental impact and difficult scalability. In this view, bare iron oxide nanoparticles (BIONs) are arousing an increasing interest and the properties and advantages of pristine surface chemistry of iron oxide are becoming popular among the scientific community. In the authors’ knowledge, rare efforts were dedicated to the use of BIONs in biomedicine, biotechnology, food industry and environmental remediation. Furthermore, literature lacks examples highlighting the potential of BIONs as platforms for the creation of more complex nanostructured architectures, and emerging properties achievable by the direct manipulation of pristine iron oxide surfaces have been little studied. Based on authors’ background on BIONs, the present review is aimed at providing hints on the future expansion of these nanomaterials emphasizing the opportunities achievable by tuning their pristine surfaces.

scholarly journals Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

2021 ◽  
Vol 12 ◽  
pp. 270-281
Author(s):  
Barbora Svitkova ◽  
Vlasta Zavisova ◽  
Veronika Nemethova ◽  
Martina Koneracka ◽  
Miroslava Kretova ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Imaging Techniques ◽  
A549 Cells ◽  
Mechanistic Study ◽  
Target Cells ◽  
Oxide Nanoparticles ◽  
The Impact

The efficient entry of nanotechnology-based pharmaceuticals into target cells is highly desired to reach high therapeutic efficiency while minimizing the side effects. Despite intensive research, the impact of the surface coating on the mechanism of nanoparticle uptake is not sufficiently understood yet. Herein, we present a mechanistic study of cellular internalization pathways of two magnetic iron oxide nanoparticles (MNPs) differing in surface chemistry into A549 cells. The MNP uptake was investigated in the presence of different inhibitors of endocytosis and monitored by spectroscopic and imaging techniques. The results revealed that the route of MNP entry into cells strongly depends on the surface chemistry of the MNPs. While serum bovine albumin-coated MNPs entered the cells via clathrin-mediated endocytosis (CME), caveolin-mediated endocytosis (CavME) or lipid rafts were preferentially involved in the internalization of polyethylene glycol-coated MNPs. Our data indicate that surface engineering can contribute to an enhanced delivery efficiency of nanoparticles.

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