Role of Surface Chemistry in Mediating the Uptake of Ultrasmall Iron Oxide Nanoparticles by Cancer Cells

2019 ◽  
Vol 11 (19) ◽  
pp. 17157-17166 ◽  
Author(s):  
Akshay A. Narkhede ◽  
Jennifer A. Sherwood ◽  
Angelo Antone ◽  
Kasie R. Coogan ◽  
Mark S. Bolding ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

scholarly journals Role of hydration and micellar shielding in tuning the structure of single crystalline iron oxide nanoparticles for designer applications

Nano Select ◽  
2021 ◽  
Author(s):  
Ramis Arbi ◽  
Amr Ibrahim ◽  
Liora Goldring‐Vandergeest ◽  
Kunyu Liang ◽  
Greg Hanta ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Single Crystalline

scholarly journals Size-Dependent Thermotherapy of Iron Oxide Nanoparticles on Human Breast Adenocarcinoma Cancer Cells

2013 ◽  
Vol 19 (S2) ◽  
pp. 218-219
Author(s):  
T. Mustafa ◽  
Y. Xu ◽  
F. Watanabe ◽  
Y. Zhang ◽  
M. Asar ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Adenocarcinoma ◽  
Oxide Nanoparticles ◽  
Human Breast ◽  
Size Dependent ◽  
Human Breast Adenocarcinoma

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

scholarly journals Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells

2007 ◽  
Vol 17 (16) ◽  
pp. 3043-3050 ◽  
Author(s):  
S. H. Wang ◽  
X. Shi ◽  
M. Van Antwerp ◽  
Z. Cao ◽  
S. D. Swanson ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Specific Targeting

Preparation of epidermal growth factor (EGF) conjugated iron oxide nanoparticles and their internalization into colon cancer cells

2010 ◽  
Vol 322 (15) ◽  
pp. 2244-2250 ◽  
Author(s):  
Mar Creixell ◽  
Adriana P. Herrera ◽  
Vanessa Ayala ◽  
Magda Latorre-Esteves ◽  
Marianela Pérez-Torres ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Iron Oxide ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Colon Cancer Cells ◽  
Epidermal Growth

scholarly journals Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

2018 ◽  
Vol 10 (5) ◽  
pp. 4548-4560 ◽  
Author(s):  
Grazyna Stepien ◽  
María Moros ◽  
Marta Pérez-Hernández ◽  
Marta Monge ◽  
Lucía Gutiérrez ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Effect Of Surface
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