scholarly journals The role of alcohol dehydrogenase genes in head and neck cancers: a systematic review and meta-analysis of ADH1B and ADH1C

Mutagenesis ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 275-286 ◽  
Author(s):  
J. S. Chang ◽  
K. Straif ◽  
N. Guha
Keyword(s):  
Systematic Review ◽  
Alcohol Dehydrogenase ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers

scholarly journals Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shree Ram Lamichhane ◽  
Thanuja Thachil ◽  
Harriet Gee ◽  
Natalie Milic
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

SBRT for Primary Head and Neck Cancers: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 108 (3) ◽  
pp. e834
Author(s):  
N. Malik ◽  
M. Kim ◽  
H. Chen ◽  
I. Poon ◽  
Z.A. Husain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers

scholarly journals Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis

2015 ◽  
Vol 32 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Niloy R. Datta ◽  
Susanne Rogers ◽  
Silvia Gómez Ordóñez ◽  
Emsad Puric ◽  
Stephan Bodis
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers

scholarly journals Systematic review and meta-analysis of radiotherapy in various head and neck cancers: Comparing photons, carbon-ions and protons

2011 ◽  
Vol 37 (3) ◽  
pp. 185-201 ◽  
Author(s):  
Bram L.T. Ramaekers ◽  
Madelon Pijls-Johannesma ◽  
Manuela A. Joore ◽  
Piet van den Ende ◽  
Johannes A. Langendijk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers ◽  
Carbon Ions

scholarly journals Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4166
Author(s):  
Chellan Kumarasamy ◽  
Vaibhav Tiwary ◽  
Krishnan Sunil ◽  
Deepa Suresh ◽  
Sameep Shetty ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Large Scale ◽  
Prognostic Markers ◽  
Meta Analysis ◽  
Head And Neck Cancers ◽  
Bibliographic Databases ◽  
Neutrophil Lymphocyte Ratio ◽  
Clinical Method ◽  
Lymphocyte Ratio

Inflammation plays a major role in cancer development and progression and has the potential to be used as a prognostic marker in cancer. Previous studies have attempted to evaluate Platelet-to-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR) or monocyte-lymphocyte ratio (MLR) as indicators of inflammation/prognostic markers in cancer, but there is no common consensus on their application in clinical practice. The aim of this systematic review and meta-analysis is to (a) assess the prognostic efficacy of all three prognostic markers in comparison to each other and (b) investigate the prognostic potential of these three markers in HNC. The study followed PRISMA guidelines, with the literature being collated from multiple bibliographic databases. Preliminary and secondary screening were carried out using stringent inclusion/exclusion criteria. Meta-analysis was carried out on selected studies using CMA software and HR as the pooled effect size metric. A total of 49 studies were included in the study. The pooled HR values of PLR, NLR and MLR indicated that they were significantly correlated with poorer OS. The pooled effect estimates for PLR, NLR and MLR were 1.461 (95% CI 1.329–1.674), 1.639 (95% CI 1.429–1.880) and 1.002 (95% CI 0.720–1.396), respectively. Significant between-study heterogeneity was observed in the meta-analysis of all three. The results of this study suggest that PLR, NLR and MLR ratios can be powerful prognostic markers in head and neck cancers that can guide treatment. Further evidence from large-scale clinical studies on patient cohorts are required before they can be incorporated as a part of the clinical method. PROSPERO Registration ID: CRD42019121008

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