scholarly journals Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa)

2016 ◽  
Vol 33 (5) ◽  
pp. 1231-1244 ◽  
Author(s):  
Alvaro Perdomo-Sabogal ◽  
Katja Nowick ◽  
Ilaria Piccini ◽  
Ralf Sudbrak ◽  
Hans Lehrach ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Binding Protein ◽  
Human Lineage ◽  
Factor Alpha ◽  
Ga Binding Protein ◽  
Protein Transcription

scholarly journals Identification of GA-Binding Protein Transcription Factor Alpha Subunit (GABPA) as a Novel Bookmarking Factor

2019 ◽  
Vol 20 (5) ◽  
pp. 1093 ◽  
Author(s):  
Shunya Goto ◽  
Masashi Takahashi ◽  
Narumi Yasutsune ◽  
Sumiki Inayama ◽  
Dai Kato ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Histone Acetylation ◽  
Binding Protein ◽  
Alpha Subunit ◽  
Upstream Region ◽  
G1 Phase ◽  
Sp1 Transcription Factor ◽  
Factor Alpha ◽  
Ga Binding Protein ◽  
Protein Transcription

Mitotic bookmarking constitutes a mechanism for transmitting transcriptional patterns through cell division. Bookmarking factors, comprising a subset of transcription factors (TFs), and multiple histone modifications retained in mitotic chromatin facilitate reactivation of transcription in the early G1 phase. However, the specific TFs that act as bookmarking factors remain largely unknown. Previously, we identified the “early G1 genes” and screened TFs that were predicted to bind to the upstream region of these genes, then identified GA-binding protein transcription factor alpha subunit (GABPA) and Sp1 transcription factor (SP1) as candidate bookmarking factors. Here we show that GABPA and multiple histone acetylation marks such as H3K9/14AC, H3K27AC, and H4K5AC are maintained at specific genomic sites in mitosis. During the M/G1 transition, the levels of these histone acetylations at the upstream regions of genes bound by GABPA in mitosis are decreased. Upon depletion of GABPA, levels of histone acetylation, especially H4K5AC, at several gene regions are increased, along with transcriptional induction at 1 h after release. Therefore, we proposed that GABPA cooperates with the states of histone acetylation to act as a novel bookmarking factor which, may negatively regulate transcription during the early G1 phase.

scholarly journals Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells

1999 ◽  
Vol 274 (49) ◽  
pp. 35203-35210 ◽  
Author(s):  
Xiao Rui Li ◽  
Anita S.-F. Chong ◽  
Jianming Wu ◽  
Kenneth A. Roebuck ◽  
Aseem Kumar ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Transcriptional Regulation ◽  
T Cell ◽  
Binding Protein ◽  
Cell Antigen ◽  
Ga Binding Protein
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