scholarly journals Assembling an Arsenal: Origin and Evolution of the Snake Venom Proteome Inferred from Phylogenetic Analysis of Toxin Sequences

2004 ◽  
Vol 21 (5) ◽  
pp. 870-883 ◽  
Author(s):  
B. G. Fry
2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Kuan Hu ◽  
Yiming Tao ◽  
Juanni Li ◽  
Zhuang Liu ◽  
Xinyan Zhu ◽  
...  

CCN gene family members have recently been identified as multifunctional regulators involved in diverse biological functions, especially in vascular and skeletal development. In the present study, a comparative genomic and phylogenetic analysis was performed to show the similarities and differences in structure and function of CCNs from different organisms and to reveal their potential evolutionary relationship. First, CCN homologs of metazoans from different species were identified. Then we made multiple sequence alignments, MEME analysis, and functional sites prediction, which show the highly conserved structural features among CCN metazoans. The phylogenetic tree was further established, and thus CCNs were found undergoing extensive lineage-specific duplication events and lineage-specific expansion during the evolutionary process. Besides, comparative analysis about the genomic organization and chromosomal CCN gene surrounding indicated a clear orthologous relationship among these species counterparts. At last, based on these research results above, a potential evolutionary scenario was generated to overview the origin and evolution of the CCN gene family.


Genome ◽  
2013 ◽  
Vol 56 (4) ◽  
pp. 233-237
Author(s):  
Leilei Zhan ◽  
Chao Jiang

Mutually exclusive splicing, one type of alternative splicing, involves selection of alternatively spliced exons arranged in tandem and creates protein products with substitution of one segment of the amino acid sequence for another. Previous studies revealed that exon 5 of 14-3-3ξ from Apis mellifera (western honeybee) had three mutually exclusive exons, while orthologous exon of Nasonia vitripennis (parasitic wasp) had only two, suggesting that cases of exon gain or loss might have happened during the evolution of hymenopteran species. In the current study, we annotated and analyzed the 14-3-3ξ genes from 20 hymenopteran species successfully, and the results of phylogenetic analysis revealed the presence of a new mutually exclusive exon in corbiculate bees. In addition, we found that duplication via staggered homologous recombination was responsible for the origin of the new exon.


2007 ◽  
Vol 26 (1) ◽  
pp. 69-85 ◽  
Author(s):  
Maurício V. Mazzi ◽  
Angelo J. Magro ◽  
Saulo F. Amui ◽  
Clayton Z. Oliveira ◽  
Fábio K. Ticli ◽  
...  

1989 ◽  
Vol 63 (5) ◽  
pp. 677-690 ◽  
Author(s):  
Fernando E. Novas

The tarsus and distal end of the tibia are described in Herrerasauridae, a family that includes the oldest known dinosaurs. This tarsal configuration is compared to those of more advanced dinosaurs and to other archosaurs. Through phylogenetic analysis of the morphological characters, a picture emerges of the evolutionary changes in the ankles of early dinosaurs.The tibia of the herrerasaurids has a quadrangular distal articular surface, with a shallow ventrolateral notch. This morphology is strikingly similar to that of the lagosuchid thecodontsPseudolagosuchusandLagosuchusand represents the most primitive tibial condition known for Dinosauria.Aside from the derived states possessed by Theropoda, Sauropodomorpha, and Ornithischia, respectively, it was impossible to recognize synapomorphies in tibiotarsal anatomy shared by these groups exclusive of Herrerasauridae. The transverse broadening of the distal end of the tibia seems to have been attained independently by ornithischians, theropods, and sauropodomorphs.The tarsus of herrerasaurids is characterized by an astragalus with a small but conspicuous lateroventral depression, by a pyramidal calcaneum with a ventromedial projection that articulates into the cavity of the astragalus just mentioned, and by a posterolaterally directed calcaneal tuber. These characters are also seen inLagosuchus(a close relative of dinosaurs), in the prosauropodRiojasaurusand, insofar as the astragalus is concerned, in the primitive dinosaurWalkeria, which suggests that dinosaurs of different lineages shared the same tarsal condition.By definition, this type of articulation between the astragalus and calcaneum follows the “crocodile-reversed” tarsal condition, suggesting that the tarsus in lagosuchids and dinosaurs could be derived from the “crocodile-reversed” pattern present in Ornithosuchidae andEuparkeria. In contrast, the mesotarsal ankle of lagosuchids and dinosaurs lacks the synapomorphies of the “crocodile-normal” ankle present in Crocodylia, Rauisuchidae, Aetosauria, and other archosaurs.It is concluded that Herrerasauridae retained the primitive tibiotarsal condition for Dinosauria, from which those of the Ornithischia, Sauropodomorpha, and Theropoda were derived. Furthermore, tibiotarsal anatomy supports monophyly of Dinosauria.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tingting Li ◽  
Dongxia Liu ◽  
Yadi Yang ◽  
Jiali Guo ◽  
Yujie Feng ◽  
...  

AbstractCorona Virus Disease 2019 (COVID-19) caused by the emerged coronavirus SARS-CoV-2 is spreading globally. The origin of SARS-Cov-2 and its evolutionary relationship is still ambiguous. Several reports attempted to figure out this critical issue by genome-based phylogenetic analysis, yet limited progress was obtained, principally owing to the disability of these methods to reasonably integrate phylogenetic information from all genes of SARS-CoV-2. Supertree method based on multiple trees can produce the overall reasonable phylogenetic tree. However, the supertree method has been barely used for phylogenetic analysis of viruses. Here we applied the matrix representation with parsimony (MRP) pseudo-sequence supertree analysis to study the origin and evolution of SARS-CoV-2. Compared with other phylogenetic analysis methods, the supertree method showed more resolution power for phylogenetic analysis of coronaviruses. In particular, the MRP pseudo-sequence supertree analysis firmly disputes bat coronavirus RaTG13 be the last common ancestor of SARS-CoV-2, which was implied by other phylogenetic tree analysis based on viral genome sequences. Furthermore, the discovery of evolution and mutation in SARS-CoV-2 was achieved by MRP pseudo-sequence supertree analysis. Taken together, the MRP pseudo-sequence supertree provided more information on the SARS-CoV-2 evolution inference relative to the normal phylogenetic tree based on full-length genomic sequences.


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