scholarly journals The centromere histone is conserved and associated with tandem repeats sharing a conserved 19 bp box in the holocentromere of Meloidogyne nematodes

2021 ◽  
Author(s):  
Evelin Despot Slade ◽  
Brankica Mravinac ◽  
Saša Širca ◽  
Philippe Castagnone-Sereno ◽  
Miroslav Plohl ◽  
...  
Keyword(s):  
Meloidogyne Incognita ◽  
Tandem Repeats ◽  
Dominant Role ◽  
The Other ◽  
Meloidogyne Hapla ◽  
Dna Constituents ◽  
Extant Species ◽  
Drive Model ◽  
Centromere Drive

Abstract Although centromeres have conserved function, centromere-specific histone H3 (CenH3) and centromeric DNA evolve rapidly. The centromere drive model explains this phenomenon as a consequence of the conflict between fast evolving DNA and CenH3, suggesting asymmetry in female meiosis as a crucial factor. We characterized evolution of the CenH3 protein in three closely related, polyploid mitotic parthenogenetic species of the Meloidogyne incognita group (MIG), and in the distantly related meiotic parthenogen Meloidogyne hapla. We identified duplication of the CenH3 gene in a putative sexual ancestral Meloidogyne. We found that one CenH3 (αCenH3) copy remained conserved in all extant species, including in distant Meloidogyne hapla, while the other copy evolved rapidly and under positive selection into four different CenH3 variants. This pattern of CenH3 evolution in Meloidogyne species suggests the sub-specialization of CenH3s in ancestral sexual species. Immunofluorescence performed on mitotic Meloidogyne incognita revealed a dominant role of αCenH3 on its centromere, while the other CenH3s have lost their function in mitosis. The observed αCenH3 chromosome distribution disclosed cluster-like centromeric organization. The ChIP-Seq analysis revealed that in M. incognita αCenH3-associated DNA dominantly comprises tandem repeats, composed of divergent monomers which share a completely conserved 19 bp-long box. Conserved αCenH3-associated DNA are also confirmed in the related mitotic MIG species suggesting preservation of both centromere protein and DNA constituents. We hypothesize that the absence of centromere drive in mitosis might allow for CenH3 and its associated DNA to achieve an equilibrium in which they can persist for long periods of time.

Plutarch’s Lives

2017 ◽  
Author(s):  
Paolo Desideri
Keyword(s):  
Special Interest ◽  
Dominant Role ◽  
The Other ◽  
The Political ◽  
Political World ◽  
History Of ◽  
The One ◽  
Of Greece ◽  
Rule Out

This chapter discusses first the general cosmological principles which lie behind Plutarch’s historiographical work, such as can be recovered through significant passages of his Delphic Dialogues. Second, it investigates the reasons why Plutarch wrote biographies, and more specifically parallel biographies, instead of outright histories: in this way, Plutarch aimed to emphasize, on the one hand, the dominant role of individual personalities in the political world of his own time, and, on the other hand, the mutual and exclusive relevance of Greece and Rome in the history of human culture. Third, the chapter seeks to connect the rise-and-fall pattern, typical of biography, with the general rise-and-fall pattern which Plutarch recognizes both in the Greek and in the Roman civilizations; through that connection one can rule out the idea that Plutarch had any providential view of history. Finally, some reflections are offered on Nietzsche’s special interest in Plutarch’s biographies.

scholarly journals Rosjanie – między narodowością a tożsamością

2012 ◽  
pp. 199-231
Author(s):  
Anna Głąb
Keyword(s):  
Ethnic Identity ◽  
Local Community ◽  
Dominant Role ◽  
Russian Language ◽  
The Other ◽  
Russian Culture ◽  
The Russian Federation ◽  
Public Opinion Polls ◽  
Opinion Polls

The article concerns the ethnic structure of the Russian Federation and the problems of national identity in the multiethnic state. A few distinct regions were identified based on ethnic, linguistic and religious components. They show that despite the Russian numerical superiority and the dominant role of Russian language and Russian culture, the Federation is a diverse state. Ethnocultural mosaics are situated throughout the state and it because of that any aspiration for larger autonomy or local separatism could destroy the Federation from the inside. A source for such aspirations may result from, for example, strong ethnic identity, which is especially important because of its naturalness, resulting from life and acting within constituent entities that were formed on the ethnic basis. The strength of ethnic identity resides in its stability, which played a significant role during the transformation period. On the other hand, the strong ethnic component in Russia is opposed to a weak civil identity, whose character is more formal. This second approach may be undermined by the results of public opinion polls. They show quite a strong and parallel identity with three groups: citizens at large, members of the same ethnic group and local community. In fact, it is difficult to precisely describe the dominant identity of the Russians. It is based on a peculiar dualism – ethnicity and citizenship.

America's Cup 1974 - An Overview - Racing for The Cup

1975 ◽  
Author(s):  
Halsey Chase Herreshoff
Keyword(s):  
Sudden Death ◽  
Dominant Role ◽  
The Other ◽  
High Point ◽  
Human Aspects ◽  
Football Team ◽  
America’S Cup ◽  
A Chain

Racing success on an America's Cup Twelve Meter Yacht depends on the perfection of many factors. We hear speculation about the dominant role of either design, skipper, sails or crew. Such an argument is useless because the various orders of merit unite as the links of a chain toward victory or defeat. In 1974 COURAGEOUS was the fastest Twelve Meter at Newport. Her sails became excellent. Her skipper was uniquely talented. Her crew was trained to a high point. She still could have lost selection, but the other necessary links of the chain were present both for the "sudden death" win over INTREPID on September 2nd and for the Cup Race victories over SOUTHERN CROSS. Participation in an America's Cup campaign has no composite parallel. The boat is doctored like a missile readying for blast-off. The crew is similar to a football team girding for the ultimate test. The designer functions as scientist, engineer and practical expediter. The skipper is both Father and race driver in the same sense as an automobile racer. The "handlers" from the tender, boatyard and house are as important as the handlers present around a prize fighter. A frantic three ring circus ensues toward developing perfection which by definition cannot be frantic. There is never enough time, but the calendar turns and the boats race during the period of development. One witnesses parallel contributions of strength, finesse, logic, endurance and some other things generally grouped under the category of "luck." Technical and human aspects combine to a most absorbing season that is only really good if you win.

scholarly journals Entrepreneurship Ecosystem Policy in Indonesia

2017 ◽  
Vol 8 (1) ◽  
pp. 110-115 ◽  
Author(s):  
Bambang Hermanto ◽  
S. E. Suryanto
Keyword(s):  
Economic Growth ◽  
Dominant Role ◽  
Descriptive Analysis ◽  
Qualitative Approach ◽  
The Other ◽  
Analysis Method ◽  
Literature Study ◽  
The Government

Abstract The role of entrepreneurs strongly influences the economic growth of a country. Every country always encourages entrepreneurship so that it could thrive by creating an entrepreneurship ecosystem. The role of entrepreneurship ecosystem will be optimal if the government can create a policy that is in synergy with the other components of the entrepreneurship ecosystem. The method of research used in this study is a qualitative approach with the literature study method. The data were obtained through books, documents, Internet, and other relevant sources. The data that was obtained then analysed using descriptive analysis method by describing the facts, which are then followed by analysis, not merely outlines, but also provides an understanding and explanation. The results of the research showed that the components of the entrepreneurship ecosystem in Indonesia are working. However, their activities are limited to running their respective programs without a comprehensive design. The government needs to play a more dominant role to optimize and synergize each component of the entrepreneurship ecosystem. One of the institutions or particular ministries should establish a policy so that the program to build the entrepreneurship ecosystem does not overlap with each other.

scholarly journals CONCEPTUAL PRINCIPLES OF LEARNING ORGANIZATION

2021 ◽  
Vol 26 (4) ◽  
pp. 47-59
Author(s):  
Marcin Kłak
Keyword(s):  
Human Capital ◽  
Learning Organization ◽  
Dominant Role ◽  
The Other ◽  
Valuable Resource ◽  
Learning Organisation ◽  
Intangible Resources ◽  
Principles Of Learning ◽  
Modern Form

The main purpose of this study is to present conceptual principles of the learning organisation as a modern form of functioning of contemporary organisations and enterprises and the awareness of the dominant role of intangible resources. The most important factor that protects organizations from solidifying is knowledge. In an organization, knowledge is produced by people and these people learn. However, learning alone is not sufficient for the success of the organization. For a lasting and sustainable process, organizational learning is required. Knowledge, on the other hand, is inextricably linked to human capital, which is now the most valuable resource of the new forms of organisation.

scholarly journals About the psychotraumatic form of dysmenorrhea (dysmenorrhea puscho-traumatiсa)

1925 ◽  
Vol 21 (2) ◽  
pp. 163-168
Author(s):  
G. Edelberg
Keyword(s):  
Dominant Role ◽  
The Body ◽  
The Other ◽  
Spiritual Life ◽  
Other Hand ◽  
Body And Soul ◽  
The One ◽  
Female Genital

No branch of medicine (not counting, of course, psychiatry) deals with psychology as much as modern gynecology. On the one hand, such gynecologists as Lahm note, and in my opinion rightly so, the dominant role of the ovaries even in the spiritual life of women: in their opinion there is no other way of psychic and physical influences on the female sexual sphere than through the ovaries, and conversely, influences coming from the sexual sphere and acting on the body and soul of women come again only through this way. On the other hand, there are gynecologists who completely ignore the role of the ovaries and believe that only the "soul" produces all kinds of changes in the female genital sphere. It is necessary, say the representatives of this view, to study only the "soul" of a woman, and then a number of incomprehensible phenomena in the field of gynecology will immediately become clear to us.

Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth
Keyword(s):  
Health Outcomes ◽  
Pain Perception ◽  
Driving Forces ◽  
Psychological Treatment ◽  
Dominant Role ◽  
Meta Analysis ◽  
General Medicine ◽  
Pain Syndrome ◽  
Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

Plasma Levels of Protein S, Protein C, and Factor X: Effects of Sex, Hormonal State and Age

1995 ◽  
Vol 74 (05) ◽  
pp. 1271-1275 ◽  
Author(s):  
C M A Henkens ◽  
V J J Bom ◽  
W van der Schaaf ◽  
P M Pelsma ◽  
C Th Smit Sibinga ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Postmenopausal Women ◽  
Protein C ◽  
Blood Donors ◽  
Premenopausal Women ◽  
Protein S ◽  
The Other ◽  
Factor X ◽  
Normal Ranges

SummaryWe measured total and free protein S (PS), protein C (PC) and factor X (FX) in 393 healthy blood donors to assess differences in relation to sex, hormonal state and age. All measured proteins were lower in women as compared to men, as were levels in premenopausal women as compared to postmenopausal women. Multiple regression analysis showed that both age and subgroup (men, pre- and postmenopausal women) were of significance for the levels of total and free PS and PC, the subgroup effect being caused by the differences between the premenopausal women and the other groups. This indicates a role of sex-hormones, most likely estrogens, in the regulation of levels of pro- and anticoagulant factors under physiologic conditions. These differences should be taken into account in daily clinical practice and may necessitate different normal ranges for men, pre- and postmenopausal women.

On the role of the dispute between "non-possessors" and "Josephites" in the culture of Moscow's prediction

1998 ◽  
pp. 61-62
Author(s):  
N. S. Jurtueva
Keyword(s):  
The Other ◽  
Moral Transformation ◽  
15Th Century ◽  
The Future ◽  
Secular Power

In the XIV century. centripetal tendencies began to appear in the Moscow principality. Inside the Russian church, several areas were distinguished. Part of the clergy supported the specificobar form. The other understood the need for transformations in society. As a result, this led to a split in the Russian church in the 15th century for "non-possessors" and "Josephites". The former linked the fate of the future with the ideology of hesychasm and its moral transformation, while the latter sought support in alliance with a strong secular power.

From Container to Claustrum: Projective Identification in Couples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman
Keyword(s):  
Psychological Health ◽  
Projective Identification ◽  
The Self ◽  
The Other ◽  
Intimate Partners ◽  
And Control ◽  
The Relationship ◽  
As If

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.

Sign in / Sign up

Export Citation Format

Share Document