scholarly journals Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line

2013 ◽  
Vol 54 (4) ◽  
pp. 649-662 ◽  
Author(s):  
Fengling Wang ◽  
Zhitong Bing ◽  
Yanan Zhang ◽  
Bin Ao ◽  
Sheng Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Melanoma Cell ◽  
Proteomic Analysis ◽  
Melanoma Cell Line ◽  
Quantitative Proteomic Analysis ◽  
Radiation Induced

scholarly journals Diterpenoid B derived from Plectranthus excisus inhibits the melanoma cell cycle in the B16 melanoma cell line

2015 ◽  
Vol 12 (3) ◽  
pp. 4578-4583 ◽  
Author(s):  
YA-NAN LIU ◽  
JUN-LIAN GU ◽  
MENG-SHI MA ◽  
HUA GUO ◽  
LONG LIU ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
B16 Melanoma ◽  
B16 Melanoma Cell

scholarly journals Cell cycle regulation by the Wee1 Inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Osamu Hashimoto ◽  
Masako Shinkawa ◽  
Takuji Torimura ◽  
Toru Nakamura ◽  
Karuppaiyah Selvendiran ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Melanoma Cell ◽  
Cell Cycle Regulation ◽  
Melanoma Cell Line ◽  
Mouse Melanoma ◽  
Mouse Melanoma Cell ◽  
B16 Mouse Melanoma ◽  
Cycle Regulation ◽  
Mouse Melanoma Cell Line

scholarly journals RIG-I acts as a tumor suppressor in melanoma via regulating the activation of MKK/p38MAPK signaling pathway

2021 ◽  
Author(s):  
Rui Guo ◽  
Shun-Yuan Lu ◽  
Jin-Xia Ma ◽  
Qian-Lan Wang ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Line ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Mapk Signaling ◽  
Phase Cell ◽  
Brdu Incorporation

Abstract Background Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. The aim of this study was to investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma. Methods We conducted RIG-I knockout and RIG-I overexpressing B16-F10 melanoma cell line, and further analyzed the RIG-I mediated change of tumor biology behaviors in spontaneous and poly I:C induced RIG-I activation status. Cell proliferation, cell cycle, apoptosis and migration were detected by CCK-8 assay, BrdU incorporation, Annexin V-PI staining assay and transwell assay, respectively. In vivo tumorigenicity was evaluated by tumor xenograft growth in nude mice and subsequently Ki67 staining and TUNEL assay. Furthermore, Western blot was utilized to explore the underlying mechanism of RIG-I in melanoma cells. Results Our data showed that RIG-I promotes the apoptosis and inhibits the proliferation by G1 phase cell-cycle arrest in B16-F10 melanoma cell line. Mechanically, RIG-I could induce the phosphorylation level of p38 MAPK and MAPK kinase MKK3/MKK4. Conclusion The current study demonstrated that RIG-I suppressed the development of melanoma via regulating the activity of MKK/p38 MAPK signaling pathway, which will be useful in the research of novel therapeutic targets for this malignant disease.

Mechanism Underlying NaF-induced Apoptosis and Cell Cycle Arrest on G361 Human Melanoma Cell Line

2011 ◽  
Vol 24 (4) ◽  
pp. 203 ◽  
Author(s):  
Do Kyun Kim ◽  
Hyeon Jin Sohn ◽  
In Ryoung Kim ◽  
Gyoo Cheon Kim ◽  
Bong Soo Park ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell ◽  
Cycle Arrest ◽  
Induced Apoptosis

H Ferritin Gene Silencing in a Human Metastatic Melanoma Cell Line: A Proteomic Analysis

2011 ◽  
Vol 10 (12) ◽  
pp. 5444-5453 ◽  
Author(s):  
Maddalena Di Sanzo ◽  
Marco Gaspari ◽  
Roberta Misaggi ◽  
Francesco Romeo ◽  
Lucia Falbo ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Metastatic Melanoma ◽  
Cell Line ◽  
Melanoma Cell ◽  
Proteomic Analysis ◽  
Melanoma Cell Line ◽  
Metastatic Melanoma Cell ◽  
Ferritin Gene

scholarly journals Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line

2007 ◽  
Vol 61 (6) ◽  
pp. 1007-1018 ◽  
Author(s):  
Teresa L. Serafim ◽  
Paulo J. Oliveira ◽  
Vilma A. Sardao ◽  
Ed Perkins ◽  
Donna Parke ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Cellular Localization
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