Study on the prevention of infection in terminal cancer patients applying epidural analgesia by adding cefazolin to anesthetics: a randomized controlled trial

2020 ◽  
Vol 50 (8) ◽  
pp. 867-872
Author(s):  
Pengcheng Xie ◽  
Zhanfang Li ◽  
Jingli Yang ◽  
Yiming Wu
Keyword(s):  
Epidural Analgesia ◽  
Bacterial Culture ◽  
Controlled Trial ◽  
Terminal Cancer ◽  
Randomized Controlled ◽  
Conventional Drug ◽  
Epidural Puncture ◽  
Vas Scores ◽  
The Mean

Abstract Objective To observe the antibacterial effect of adding cefazolin into anesthetics in patients with terminal cancer undergoing long-term epidural analgesia. Methods Patients undergoing epidural analgesia with terminal cancer were randomly divided into two groups: the conventional drug group (group C) and the cefazolin group (group G). Both groups were given levobupivacaine and morphine, while cefazolin was added to group G. The mean arterial pressure (MAP), heart rate (HR), respiratory rates (R), visual analogue scale (VAS) scores, satisfaction and complications of patients in the two groups were observed. 3 ml of the used analgesic was taken for bacterial culture when replacing the new analgesic case. Results HR, MAP, R, VAS scores, dosages of morphine, satisfaction of the analgesic and the complications were not significantly different between the two groups (P > 0.05). The overall satisfaction of patients in group G was significantly higher than that in group C (P < 0.05). One patient’s anesthetics in group C were infected with colibacillus. Four patients in group C got infected in their epidural puncture sites. There was no infection in group G (P < 0.05). Conclusion Adding cefazolin to local anesthetics could effectively prevent bacterial infection and ensured the safety of epidural analgesia for patients with terminal cancer.

scholarly journals EPIDURAL ANALGESIA

2007 ◽  
Vol 14 (02) ◽  
pp. 225-228
Author(s):  
FAROOQ AHMAD
Keyword(s):  
Epidural Analgesia ◽  
Daily Living ◽  
Controlled Trial ◽  
Military Hospital ◽  
Low Back ◽  
Epidural Group ◽  
Randomized Controlled ◽  
Trial Setting

Objective: To find out the association of epidural analgesia duringlabour with long termbackache. Design: A randomized controlled trial. Setting: Combined Military Hospital Rawalpindi.Period: March 2002 to Feb 2003. Material and Methods: 100 randomized to epidural group and 100 randomized tonon-epidural group. In the follow up study 92 women were from the epidural group and 89 from the non-epidural group.Results: There were no significant differences between groups in demographic details or other key characteristics.There were no significant differences in the onset or duration of low back pain. There were no differences in selfreported measures of disability in activities of daily living and no significant differences in measurements of spinalmobility. Conclusions: The incidence of new long term backache was not significantly increased in women whoreceived epidural analgesia in labour. Motor block resulting from epidural local anaesthetic administration was not asignificant factor in the development of backache.

The Use of a Fine-Gauge Needle to Reduce Pain in Open Carpal Tunnel Decompression: A Randomized Controlled Trial

2005 ◽  
Vol 30 (6) ◽  
pp. 615-617 ◽  
Author(s):  
A. C. WATTS ◽  
J. MCEACHAN
Keyword(s):  
Carpal Tunnel ◽  
Local Anaesthetic ◽  
Controlled Trial ◽  
Verbal Response ◽  
Controlled Study ◽  
Response Scale ◽  
Randomized Controlled ◽  
Vas Scores ◽  
The Mean ◽  
23 Gauge

This randomized controlled study on 86 patients compared the level of pain experienced by patients on instillation of local anaesthetic into the palm with a 23-gauge and a 27-gauge (dental) needle in open carpal tunnel decompression. Patients were asked to score the amount of pain they experienced during the injection of the local anaesthetic and their level of anxiety about future injections using a visual analogue scale (VAS) and a four-point verbal response scale (VRS). The mean pain and anxiety scores on the VAS were significantly lower in the dental needle group. There was significant correlation between the pain and anxiety VAS scores. When infiltrating local anaesthetic into the palm for open carpal tunnel decompression, the use of a fine (dental) needle can reduce the pain on that occasion and the anxiety concerning future injections likely to be experienced by the patient.

Long-term Effects of Epidural Analgesia in Labor: A Randomized Controlled Trial Comparing High Dose with Two Mobile Techniques

Birth ◽  
2011 ◽  
Vol 38 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Matthew J. A. Wilson ◽  
Phillip A. S. Moore ◽  
Andrew Shennan ◽  
Robert J. Lancashire ◽  
Christine MacArthur
Keyword(s):  
Randomized Controlled Trial ◽  
Epidural Analgesia ◽  
Controlled Trial ◽  
High Dose ◽  
Long Term Effects ◽  
Randomized Controlled

scholarly journals A 3-Arm, Randomized, Controlled Trial of Heat-Sensitive Moxibustion Therapy to Determine Superior Effect among Patients with Lumbar Disc Herniation

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rixin Chen ◽  
Mingren Chen ◽  
Tongsheng Su ◽  
Meiqi Zhou ◽  
Jianhua Sun ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Usual Care ◽  
Moxibustion Therapy ◽  
Controlled Trial ◽  
Lumbar Disc ◽  
Randomized Controlled ◽  
Conventional Drug ◽  
Superior Effect ◽  
Sample Trial ◽  
The Mean

Systematic reviews of moxibustion for LDH have identified ponderable evidence, especially for heat-sensitive moxibustion (HSM). Therefore, we designed and carried out the large sample trial to evaluate it. 456 patients were recruited from 4 centers in China and were randomly divided into three groups by the ratio of 1 : 1 : 1 to HSM (152) group, conventional moxibustion (152) group, and conventional drug plus acupuncture (152) group. Compared with usual care, there was a statistically significant reduction in mean M-JOA score at 2 weeks and 6 months for HSM (3.8 ± 2.6 versus 8.5 ± 2.9; 3.7 ± 2.2 versus 10.1 ± 2.9) and conventional moxibustion (7.9 ± 3.0 versus 8.5 ± 2.9; 8.9 ± 3.1 versus 10.1 ± 2.9). Compared with conventional moxibustion group, HSM group showed greater improvement in all the outcomes. The mean dose of moxibustion was 41.13 ± 5.26 (range 21–60) minutes in the HSM group. We found that HSM was more effective in treating patients with LDH, compared with conventional moxibustion and conventional drug plus acupuncture. This finding indicated that the application of moxibustion on the heat-sensitive points is a good moxibustion technique in treating disease.

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