scholarly journals Regulation of bone and cartilage development by network between BMP signalling and transcription factors

2012 ◽  
Vol 151 (3) ◽  
pp. 247-254 ◽  
Author(s):  
R. Nishimura ◽  
K. Hata ◽  
T. Matsubara ◽  
M. Wakabayashi ◽  
T. Yoneda
Keyword(s):  
Transcription Factors ◽  
Cartilage Development ◽  
Bone And Cartilage Development ◽  
Bmp Signalling ◽  
And Cartilage

Regulation of transcriptional network system during bone and cartilage development

2015 ◽  
Vol 57 (4) ◽  
pp. 165-170
Author(s):  
Riko Nishimura ◽  
Kenji Hata ◽  
Fumiyo Ikeda ◽  
Takuma Matsubara ◽  
Katsuhiko Amano ◽  
...  
Keyword(s):  
Transcriptional Network ◽  
Network System ◽  
Cartilage Development ◽  
Bone And Cartilage Development ◽  
And Cartilage

scholarly journals RECESSIVE MULTIPLE EPIPHYSEAL DYSPLASIA: A CASE REPORT

2019 ◽  
Keyword(s):  
Case Report ◽  
Autosomal Recessive ◽  
Multiple Epiphyseal Dysplasia ◽  
Long Bones ◽  
Dominant Type ◽  
Cartilage Development ◽  
Bone And Cartilage Development ◽  
Epiphyseal Dysplasia ◽  
And Cartilage ◽  
Difficulty Walking

Multiple epiphyseal dysplasia (MED) is characterized by abnormal bone and cartilage development particularly affecting epiphysis of long bones. Individuals with MED present during childhood presents with hip pain, knee pain and waddling gait. The autosomal recessive MED is differentiated from the dominant type by the presence of hands, knees and feet malformations with scoliosis. We present here, a case of autosomal recessive MED, an eleven and half years old boy who presented with pain in knees, difficulty walking, abnormal fingers and abnormal toes. The radiographs of hands, knees and pelvis were suggestive of an abnormal epiphyseal development. After diagnosis, patient was counseled and he was advised analgesics and different exercises.

Abnormalities in bone and cartilage development in the talpid3 mutant of the fowl

Development ◽  
1968 ◽  
Vol 19 (3) ◽  
pp. 327-339
Author(s):  
J. R. Hinchliffe ◽  
D. A. Ede
Keyword(s):  
Bone Formation ◽  
Chick Embryos ◽  
Cartilage Development ◽  
Bone And Cartilage Development ◽  
Complete Failure ◽  
Membranous Skeleton ◽  
And Cartilage

The complex pleiotropic pattern of damage caused in chick embryos by the talpid3 gene has been described previously by Ede & Kelly (1964a, b) and Hinchliffe & Ede (1967). The pattern of segregation of the mesenchyme in forming the precartilaginous or membranous skeleton is abnormal, and the resulting cartilaginous skeleton shows characteristic fusions of the vertebrae and of the limb elements. By 11 days of development there is a complete failure of cartilage-replacement bone to appear, even in the more normally formed cartilage rudiments (e.g. ribs, scapula, coracoid, ilium). By contrast, ossification to give the membrane bones (the clavicle and bones of the skull and jaws), which are formed directly from condensations in the mesenchyme, proceeds normally. This paper describes the attempts made by experimental and histochemical means to account for the failure of cartilage-replacement bone formation.

scholarly journals Regulation of Cartilage Development and Diseases by Transcription Factors

2017 ◽  
Vol 24 (3) ◽  
pp. 147 ◽  
Author(s):  
Riko Nishimura ◽  
Kenji Hata ◽  
Yoshifumi Takahata ◽  
Tomohiko Murakami ◽  
Eriko Nakamura ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Cartilage Development

scholarly journals Chondromodulin I Is a Bone Remodeling Factor

2003 ◽  
Vol 23 (2) ◽  
pp. 636-644 ◽  
Author(s):  
Yuko Nakamichi ◽  
Chisa Shukunami ◽  
Takashi Yamada ◽  
Ken-ichi Aihara ◽  
Hirotaka Kawano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Remodeling ◽  
Endochondral Bone Formation ◽  
Growth Stages ◽  
Mineral Density ◽  
Targeted Disruption ◽  
Endochondral Bone ◽  
Cartilage Development ◽  
And Cartilage ◽  
Cultured Chondrocytes

ABSTRACT Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I−/− mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I−/− mice. Thus, the present study established that ChM-I is a bone remodeling factor.

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