scholarly journals Costing Methods as a Means to Measure the Costs of Pharmacogenomics Testing

2020 ◽  
Vol 5 (5) ◽  
pp. 1005-1016 ◽  
Author(s):  
Stavroula Siamoglou ◽  
Kariofyllis Karamperis ◽  
Christina Mitropoulou ◽  
George P Patrinos
Keyword(s):  
Genetic Testing ◽  
Blood Sample ◽  
Dna Isolation ◽  
Clinical Implementation ◽  
Sample Collection ◽  
Technical Process ◽  
Private Providers ◽  
The Cost ◽  
First Time ◽  
And Personalized Medicine

Abstract Clinical implementation of pharmacogenomics and personalized medicine interventions relies on addressing important financial aspects of the delivery of genetic testing to the patients, be it from public or private providers. Details on how to determine the cost items of the genetic testing are often limited. The goal of this study is to present a costing methodology in order to estimate and measure the costs as far as the technical process of pharmacogenomics testing is concerned. Moreover, an overall cost mindset strategy based on the selective genotyping workflow to guide specialized laboratories of interest effectively is provided. We particularly accounted for the resources consumed within the laboratory premises such as cost of reagents for DNA isolation, cost of consumables, cost of personnel, while costs associated with patient recruitment, blood sample collection and maintenance, administration costs in the hospital, and costs of blood sample shipment were not taken into consideration. Our article presents the first-time detailed information on a costing framework for pharmacogenomic testing that could be employed to laboratories involved in routine clinical implementation of pharmacogenomics.

scholarly journals SIMPLIFIED DIAGNOSIS OF MALARIA INFECTION: GFM/PCR/ELISA A SIMPLIFIED NUCLEIC ACID AMPLIFICATION TECHNIQUE BY PCR/ELISA

1998 ◽  
Vol 40 (5) ◽  
pp. 333-334 ◽  
Author(s):  
Ricardo Luiz Dantas MACHADO ◽  
Denise Oliveira GARRET ◽  
Ipemida Sullayman ADAGU ◽  
David Charles WARHURST ◽  
Marinete Marins PÓVOA
Keyword(s):  
Nucleic Acid ◽  
Genetic Analysis ◽  
Blood Sample ◽  
Malaria Infection ◽  
Nucleic Acid Amplification ◽  
Sample Collection ◽  
Amplification Technique ◽  
The Cost ◽  
Nucleic Acid Amplification Technique

We report an adaptation of a technique for the blood sample collection (GFM) as well as for the extraction and amplification of Plasmodium DNA for the diagnosis of malaria infection by the PCR/ELISA. The method of blood sample collection requires less expertise and saves both time and money, thus reducing the cost by more than half. The material is also suitable for genetic analysis in either fresh or stored specimens prepared by this method.

An Evaluation of Provincial Macroeconomic Performance in Vietnam

2017 ◽  
pp. 34-47
Author(s):  
Hoi Le Quoc ◽  
Nam Pham Xuan ◽  
Tuan Nguyen Anh
Keyword(s):  
Development Strategy ◽  
Institutional Transformation ◽  
Economic Indicators ◽  
Macroeconomic Performance ◽  
Economic Development Strategy ◽  
Socio Economic Development ◽  
The Cost ◽  
Development Objectives ◽  
First Time

The study was targeted at developing a methodology for constructing a macroeconomic performance index at a provincial level for the first time in Vietnam based on 4 groups of measurements: (i) Economic indicators; (ii) oriented economic indicators; (iii) socio-economic indicators; and (iv) economic - social – institutional indicators. Applying the methodology to the 2011 - 2015 empirical data of all provinces in Vietnam, the research shows that the socio-economic development strategy implemented by those provinces did not provide balanced outcomes between growth and social objectives, sustainability and inclusiveness. Many provinces focused on economic growth at the cost of structural change, equality and institutional transformation. In contrast, many provinces were successful in improving equality but not growth. Those facts threaten the long-term development objectives of the provinces.

scholarly journals Autism Tsunami: the Impact of Rising Prevalence on the Societal Cost of Autism in the United States

2021 ◽  
Author(s):  
Mark Blaxill ◽  
Toby Rogers ◽  
Cynthia Nevison
Keyword(s):  
Forecast Model ◽  
The United States ◽  
Population Projections ◽  
Base Case ◽  
Prevention Strategies ◽  
Total Base ◽  
Cost Categories ◽  
The Cost ◽  
The Impact ◽  
First Time

AbstractThe cost of ASD in the U.S. is estimated using a forecast model that for the first time accounts for the true historical increase in ASD. Model inputs include ASD prevalence, census population projections, six cost categories, ten age brackets, inflation projections, and three future prevalence scenarios. Future ASD costs increase dramatically: total base-case costs of $223 (175–271) billion/year are estimated in 2020; $589 billion/year in 2030, $1.36 trillion/year in 2040, and $5.54 (4.29–6.78) trillion/year by 2060, with substantial potential savings through ASD prevention. Rising prevalence, the shift from child to adult-dominated costs, the transfer of costs from parents onto government, and the soaring total costs raise pressing policy questions and demand an urgent focus on prevention strategies.

scholarly journals A METHODOLOGY TO SUPPORT COMPANIES IN THE FIRST STEPS TOWARDS DE-MANUFACTURING

2021 ◽  
Vol 1 ◽  
pp. 131-140
Author(s):  
Federica Cappelletti ◽  
Marta Rossi ◽  
Michele Germani ◽  
Mohammad Shadman Hanif
Keyword(s):  
Environmental Impact ◽  
End Of Life ◽  
Design Stage ◽  
Life Strategies ◽  
Disassembly Sequence ◽  
The Status ◽  
The Cost ◽  
Technical Solutions ◽  
First Time ◽  
Complex Activities

AbstractDe-manufacturing and re-manufacturing are fundamental technical solutions to efficiently recover value from post-use products. Disassembly in one of the most complex activities in de-manufacturing because i) the more manual it is the higher is its cost, ii) disassembly times are variable due to uncertainty of conditions of products reaching their EoL, and iii) because it is necessary to know which components to disassemble to balance the cost of disassembly. The paper proposes a methodology that finds ways of applications: it can be applied at the design stage to detect space for product design improvements, and it also represents a baseline from organizations approaching de-manufacturing for the first time. The methodology consists of four main steps, in which firstly targets components are identified, according to their environmental impact; secondly their disassembly sequence is qualitatively evaluated, and successively it is quantitatively determined via disassembly times, predicting also the status of the component at their End of Life. The aim of the methodology is reached at the fourth phase when alternative, eco-friendlier End of Life strategies are proposed, verified, and chosen.

A standardized terminology of spines in the order Siluriformes (Actinopterygii: Ostariophysi)

2021 ◽  
Author(s):  
Gustavo A Ballen ◽  
Mario C C De Pinna
Keyword(s):  
Comparative Anatomy ◽  
Appendicular Skeleton ◽  
Extensive Literature ◽  
Direct Examination ◽  
Dorsal Fin ◽  
Anatomical Nomenclature ◽  
Standardized Terminology ◽  
The Cost ◽  
First Time ◽  
Terminology System

Abstract A standardized terminology for the anatomy of pectoral- and dorsal-fin spines in the order Siluriformes is proposed based on an extensive literature review and direct examination of representatives of the order. The adult anatomy of the spines is described in detail. Terminology of various spine parts are reviewed and standardized, each term provided with a synonymic list organizing previous usage. Most of the structures treated have been recorded and named in the literature, but some are herein named for the first time. A quantitative approach is proposed for orienting decisions on name usage, aiming at minimizing differences between the terminology proposed and the vast amount of pre-existing literature, herein called the cost function. It is expected that this system will aid efforts in organizing the chaotic anatomical nomenclature of the appendicular skeleton in Siluriformes, and provide a solid basis for advances in comparative anatomy and nomenclature. The proposed terminology system has potential application on a number of fields that utilize information from catfish spines, ranging from taxonomy to phylogenetic systematics to paleontology and archaeology.

Empowering and Directive Leadership: The Cost of Changing Styles

2021 ◽  
pp. 227853372110083
Author(s):  
Smita Mukherjee ◽  
Zubin R. Mulla
Keyword(s):  
Laboratory Experiment ◽  
Leadership Styles ◽  
Leadership Style ◽  
Affective Commitment ◽  
Team Outcomes ◽  
History Of ◽  
Satisfaction With The Leader ◽  
The Cost ◽  
First Time

We examine the cost of leaders changing between empowering and directive leadership styles on team outcomes. In a laboratory experiment, we collected data from 240 participants in 80 teams. Confederates enacted different leadership styles and led teams of participants in performing a series of tasks. When leaders changed their style from directive to empowering, teams took time to respond in terms of higher satisfaction with leader and affective commitment. However, when leaders changed their style from empowering to directive, the deterioration of satisfaction with leader and reduction in affective commitment were immediate. Moreover, teams of leaders who had been consistently directive showed higher affective commitment as compared to teams of leaders who had a history of being empowering but later shifted to being directive. First time managers can get inputs on how they should enact their leadership style and be aware that switching between styles may impose long-term costs on the team’s affective commitment and satisfaction with the leader.

scholarly journals Cost-Effectiveness of Colorectal Cancer Genetic Testing

2021 ◽  
Vol 18 (16) ◽  
pp. 8330
Author(s):  
Abdul Rahman Ramdzan ◽  
Mohd Rizal Abdul Manaf ◽  
Azimatun Noor Aizuddin ◽  
Zarina A. Latiff ◽  
Keng Wee Teik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Testing ◽  
Cost Effectiveness ◽  
Cancer Survival ◽  
Screening Method ◽  
Targeted Prevention ◽  
Activity Based Costing ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Cost

Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths worldwide. Approximately 3–5% of CRCs are associated with hereditary cancer syndromes. Individuals who harbor germline mutations are at an increased risk of developing early onset CRC, as well as extracolonic tumors. Genetic testing can identify genes that cause these syndromes. Early detection could facilitate the initiation of targeted prevention strategies and surveillance for CRC patients and their families. The aim of this study was to determine the cost-effectiveness of CRC genetic testing. We utilized a cross-sectional design to determine the cost-effectiveness of CRC genetic testing as compared to the usual screening method (iFOBT) from the provider’s perspective. Data on costs and health-related quality of life (HRQoL) of 200 CRC patients from three specialist general hospitals were collected. A mixed-methods approach of activity-based costing, top-down costing, and extracted information from a clinical pathway was used to estimate provider costs. Patients and family members’ HRQoL were measured using the EQ-5D-5L questionnaire. Data from the Malaysian Study on Cancer Survival (MySCan) were used to calculate patient survival. Cost-effectiveness was measured as cost per life-year (LY) and cost per quality-adjusted life-year (QALY). The provider cost for CRC genetic testing was high as compared to that for the current screening method. The current practice for screening is cost-saving as compared to genetic testing. Using a 10-year survival analysis, the estimated number of LYs gained for CRC patients through genetic testing was 0.92 years, and the number of QALYs gained was 1.53 years. The cost per LY gained and cost per QALY gained were calculated. The incremental cost-effectiveness ratio (ICER) showed that genetic testing dominates iFOBT testing. CRC genetic testing is cost-effective and could be considered as routine CRC screening for clinical practice.

scholarly journals An Optimized Mathematical Model for Items Supplies Planning of a Logistic System

2016 ◽  
Vol 10 (10) ◽  
pp. 133
Author(s):  
Mohammad Ali Nasiri Khalili ◽  
Mostafa Kafaei Razavi ◽  
Morteza Kafaee Razavi
Keyword(s):  
Mathematical Model ◽  
Mixed Integer ◽  
Logistics System ◽  
Proposed Model ◽  
Multiple Objective Decision Making ◽  
System Requirements ◽  
Purchasing Logistics ◽  
The Cost ◽  
The Mathematical Model ◽  
First Time

Items supplies planning of a logistic system is one of the major issue in operations research. In this article the aim is to determine how much of each item per month from each supplier logistics system requirements must be provided. To do this, a novel multi objective mixed integer programming mathematical model is offered for the first time. Since in logistics system, delivery on time is very important, the first objective is minimization of time in delivery on time costs (including lack and maintenance costs) and the cost of purchasing logistics system. The second objective function is minimization of the transportation supplier costs. Solving the mathematical model shows how to use the Multiple Objective Decision Making (MODM) can provide the ensuring policy and transportation logistics needed items. This model is solved with CPLEX and computational results show the effectiveness of the proposed model.

Pediatric Blood Sample Collection From a Pre-Existing Peripheral Intravenous (PIV) Catheter

2014 ◽  
Vol 29 (5) ◽  
pp. 451-456 ◽  
Author(s):  
Heather Braniff ◽  
Ann DeCarlo ◽  
Amy Corey Haskamp ◽  
Marion E. Broome
Keyword(s):  
Blood Sample ◽  
Sample Collection

scholarly journals Visual multiple cross displacement amplification for the rapid identification of S. agalactiae immediately from vaginal and rectal swabs

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xueqin Cheng ◽  
Zhiqian Dou ◽  
Jing Yang ◽  
Dexi Liu ◽  
Yulong Gu ◽  
...  
Keyword(s):  
Pathogen Detection ◽  
Clinical Specimen ◽  
Rapid Identification ◽  
Sample Collection ◽  
Special Equipment ◽  
Multiple Cross ◽  
Rectal Swabs ◽  
Cost Efficient ◽  
The Cost ◽  
Positive Results

AbstractStreptococcus agalactiae (S. agalactiae) is an important pathogen that can lead to neonatus and mother infection. The current existing techniques for the identification of S. agalactiae are limited by accuracy, speed and high-cost. Therefore, a new multiple cross displacement amplification (MCDA) assay was developed for test of the target pathogen immediately from vaginal and rectal swabs. MCDA primers screening were conducted targeting S. agalactiae pcsB gene, and one set of MCDA primers with better rapidity and efficiency was selected for establishing the S. agalactiae-MCDA assay. As a result, the MCDA method could be completed at a constant temperature of 61 °C, without the requirement of special equipment. The detection limit is 250 fg (31.5 copies) per reaction, all S. agalactiae strains displayed positive results, but not for non-S. agalactiae strains. The visual MCDA assay detected 16 positive samples from 200 clinical specimen, which were also detected positive by enrichment/qPCR. While the CHROMagar culture detected 6 positive samples. Thus, the MCDA assay is prefer to enrichment/qPCR and culture for detecting S. agalactiae from clinical specimen. Particularly, the whole test of MCDA takes about 63.1 min, including sample collection (3 min), DNA preparation (15 min), MCDA reaction (45 min) and result reporting (6 s). In addition, the cost was very economic, with only US$ 4.9. These results indicated that our S. agalaciae-MCDA assay is a rapid, sensitive and cost-efficient technique for target pathogen detection, and is more suitable than conventional assays for an urgent detection, especially for 'on-site' laboratories and resource-constrained settings.

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