scholarly journals Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control

2013 ◽  
Vol 68 (12) ◽  
pp. 2927-2933 ◽  
Author(s):  
C. A. Marwick ◽  
N. Yu ◽  
M. C. Lockhart ◽  
C. C. McGuigan ◽  
C. Wiuff ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clostridium Difficile ◽  
Older People ◽  
Clostridium Difficile Infection ◽  
Care Home ◽  
Case Control ◽  
Antibiotic Exposure ◽  
Nested Case Control

scholarly journals Diarrhoea in general practice: when should a Clostridium difficile infection be considered? Results of a nested case-control study

2014 ◽  
Vol 20 (12) ◽  
pp. O1067-O1074 ◽  
Author(s):  
M.P.M. Hensgens ◽  
O.M. Dekkers ◽  
A. Demeulemeester ◽  
A.G.M. Buiting ◽  
P. Bloembergen ◽  
...  
Keyword(s):  
General Practice ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Risk Factors for Recurrent Clostridium difficile Infection in Children: A Nested Case-Control Study

2015 ◽  
Vol 167 (2) ◽  
pp. 384-389 ◽  
Author(s):  
Larry K. Kociolek ◽  
Hannah L. Palac ◽  
Sameer J. Patel ◽  
Stanford T. Shulman ◽  
Dale N. Gerding
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Case Control Study ◽  
Case Control ◽  
Recurrent Clostridium Difficile Infection ◽  
Nested Case Control ◽  
Control Study

scholarly journals Incidence of and risk factors for community-associated Clostridium difficile infection: A nested case-control study

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Jennifer L Kuntz ◽  
Elizabeth A Chrischilles ◽  
Jane F Pendergast ◽  
Loreen A Herwaldt ◽  
Philip M Polgreen
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Implementation of Global Strategies to Prevent Hospital-Onset Clostridium difficile Infection: Targeting Proton Pump Inhibitors and Probiotics

2017 ◽  
Vol 51 (10) ◽  
pp. 848-854 ◽  
Author(s):  
Paul O. Lewis ◽  
Timothy S. Lundberg ◽  
Jennifer L. Tharp ◽  
Clay W. Runnels
Keyword(s):  
Cohort Study ◽  
Clostridium Difficile ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Clostridium Difficile Infection ◽  
Retrospective Cohort ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Order Sets ◽  
Global Strategies

Background: Proton pump inhibitors (PPIs) have been identified as a significant risk factor for the development of Clostridium difficile infection (CDI). Probiotics given concurrently with antibiotics have been shown to have a moderate impact on preventing CDI. Objective: To evaluate the effectiveness of hospital-wide interventions designed to reduce PPI use and increase probiotics and whether these interventions were associated with a change in the incidence of hospital onset (HO)-CDI. Methods: This retrospective cohort study compared 2 fiscal years: July 2013 to June 2014 (FY14) and July 2014 to June 2015 (FY15). In July of FY15, global educational initiatives were launched targeting PPIs. Additionally, a HO-CDI prevention bundle was added to antibiotic-containing order sets targeting probiotics. Overall PPI use, probiotic use, and incidence of HO-CDI were recorded and compared for each cohort. Charts were also reviewed for patients who developed HO-CDI for the presence and appropriateness of a PPI and presence of probiotics. Results: The interventions resulted in a decrease in PPI use by 14% or 96 doses/1000 patient days (TPD; P = 0.0002) and a reduction in IV PPI use by 31% or 71 doses/TPD ( P = 0.0008). Probiotic use increased by 130% or 126 doses/TPD ( P = 0.0006). The incidence of HO-CDI decreased by 20% or 0.1 cases/TPD ( P = 0.04). Conclusions: A collaborative, multifaceted educational initiative directed at highlighting the risks associated with PPI use was effective in reducing PPI prescribing. The implementation of a probiotic bundle added to antibiotic order sets was effective in increasing probiotic use. These interventions were associated with a decrease in incidence of HO-CDI.

scholarly journals Genetic determinants of trehalose utilization are not associated with severe Clostridium difficile infection

2019 ◽  
Author(s):  
Katie Saund ◽  
Krishna Rao ◽  
Vincent B. Young ◽  
Evan S. Snitkin
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Case Control Study ◽  
Severe Infection ◽  
Case Control ◽  
Genetic Determinants ◽  
Severe Clostridium Difficile Infection ◽  
Control Study

ABSTRACTIn a case-control study of patients with C. difficile infection we found no statistically significant association between the presence of trehalose utilization variants in infecting C. difficile strains and development of severe infection. These results do not support trehalose utilization conferring enhanced virulence in the context of human C. difficile infections.

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