scholarly journals Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation

2011 ◽  
Vol 67 (1) ◽  
pp. 191-201 ◽  
Author(s):  
O. Simonetti ◽  
O. Cirioni ◽  
G. Lucarini ◽  
F. Orlando ◽  
R. Ghiselli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Metalloproteinase 9

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

scholarly journals Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers: Response to Liu et al.

Diabetes Care ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. e138-e138 ◽  
Author(s):  
M. Muller ◽  
C. Trocme ◽  
F. Morel ◽  
S. Halimi ◽  
P. Y. Benhamou
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Diabetic Foot ◽  
Matrix Metalloproteinase 9 ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Metalloproteinase 9

scholarly journals Matrix metalloproteinase-9 delays wound healing in a murine wound model

Surgery ◽  
2010 ◽  
Vol 147 (2) ◽  
pp. 295-302 ◽  
Author(s):  
Matthew J. Reiss ◽  
Yan-Ping Han ◽  
Edwin Garcia ◽  
Mytien Goldberg ◽  
Hong Yu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Wound Model ◽  
Metalloproteinase 9

Matrix metalloproteinase 9 (MMP9) in wound healing of diabetic foot ulcer: Molecular target and structure-based drug design

2018 ◽  
Vol 22 ◽  
pp. 1-13 ◽  
Author(s):  
Maywan Hariono ◽  
Sri H. Yuliani ◽  
Enade P. Istyastono ◽  
Florentinus D.O. Riswanto ◽  
Christophorus F. Adhipandito
Keyword(s):  
Wound Healing ◽  
Drug Design ◽  
Matrix Metalloproteinase ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Molecular Target ◽  
Matrix Metalloproteinase 9 ◽  
Structure Based Drug Design ◽  
Metalloproteinase 9

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9

2019 ◽  
Vol 28 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Trung T. Nguyen ◽  
Jeffrey I. Jones ◽  
William R. Wolter ◽  
Rocio L. Pérez ◽  
Valerie A. Schroeder ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Matrix Metalloproteinase 9 ◽  
Diabetic Mice ◽  
Active Matrix ◽  
Metalloproteinase 9

scholarly journals Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers: Response to Muller et al.

Diabetes Care ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. e137-e137 ◽  
Author(s):  
Y. Liu ◽  
D. Min ◽  
T. Bolton ◽  
V. Nube ◽  
S. M. Twigg ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Diabetic Foot ◽  
Matrix Metalloproteinase 9 ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Metalloproteinase 9

Correlation between interleukin‐6 and matrix metalloproteinase‐9 in early wound healing in children

1999 ◽  
Vol 7 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Olli T. Pajulo ◽  
Kari J Pulkki ◽  
Markku S. Alanen ◽  
Mikko S. Reunanen ◽  
Kalle K. Lertola ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Interleukin 6 ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9 ◽  
Early Wound
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