scholarly journals Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers

2005 ◽  
Vol 55 (5) ◽  
pp. 742-747 ◽  
Author(s):  
Luis Alou ◽  
Lorenzo Aguilar ◽  
David Sevillano ◽  
María-José Giménez ◽  
Beatriz Laguna ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Oral Dose ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
Bactericidal Activity ◽  
Specific Antibodies ◽  
Serum Bactericidal Activity

scholarly journals Urinary Bactericidal Activity of Extended-Release Ciprofloxacin (1,000 Milligrams) versus Levofloxacin (500 Milligrams) in Healthy Volunteers Receiving a Single Oral Dose

2006 ◽  
Vol 50 (11) ◽  
pp. 3947-3949 ◽  
Author(s):  
Florian M. E. Wagenlehner ◽  
Martina Kinzig-Schippers ◽  
Uwe Tischmeyer ◽  
Christine Wagenlehner ◽  
Fritz Sörgel ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
Bactericidal Activity ◽  
Proteus Mirabilis ◽  
Extended Release

ABSTRACT Twelve volunteers received a single oral dose of 1,000 mg extended-release (XR) ciprofloxacin versus 500 mg levofloxacin to assess urinary bactericidal titers (UBTs) against common uropathogens. Areas under UBT-time curves were significantly larger for Proteus mirabilis with XR ciprofloxacin and for staphylococci with levofloxacin.

scholarly journals Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

1997 ◽  
Vol 41 (6) ◽  
pp. 1389-1391 ◽  
Author(s):  
L Aguilar ◽  
J Rosendo ◽  
I P Balcabao ◽  
M Martín ◽  
M J Giménez ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Phase I ◽  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
Resistant Strain ◽  
Phase I Study ◽  
Peak Level ◽  
Crossover Fashion ◽  
Activity Time ◽  
Serum Bactericidal Activity

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose

Chemotherapy ◽  
2011 ◽  
Vol 57 (2) ◽  
pp. 97-107 ◽  
Author(s):  
Florian M.E. Wagenlehner ◽  
Christine M. Wagenlehner ◽  
Birgit Blenk ◽  
Holger Blenk ◽  
Sabine Schubert ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
Bactericidal Activity
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