Serum bactericidal activity against Moraxella catarrhalis and Streptococcus pneumoniae after administration of four oral cephalosporins in healthy volunteers

1995 ◽  
Vol 35 (1) ◽  
pp. 233-235 ◽  
Author(s):  
S. W. LEMMEN ◽  
T. HAUER ◽  
K. ANDING ◽  
I. ENGELS ◽  
F. D. DASCHNER
Keyword(s):  
Streptococcus Pneumoniae ◽  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
Moraxella Catarrhalis ◽  
Serum Bactericidal Activity

scholarly journals Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

1997 ◽  
Vol 41 (6) ◽  
pp. 1389-1391 ◽  
Author(s):  
L Aguilar ◽  
J Rosendo ◽  
I P Balcabao ◽  
M Martín ◽  
M J Giménez ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Phase I ◽  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
Resistant Strain ◽  
Phase I Study ◽  
Peak Level ◽  
Crossover Fashion ◽  
Activity Time ◽  
Serum Bactericidal Activity

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

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