scholarly journals  -Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli

2003 ◽  
Vol 52 (4) ◽  
pp. 576-582 ◽  
Author(s):  
H. Hirakawa
Keyword(s):  
Escherichia Coli ◽  
Signal Transduction ◽  
Response Regulators ◽  
Two Component ◽  
Two Component Signal Transduction ◽  
Signal Transduction Systems

scholarly journals A Selective Tether Recruits Activated Response Regulator CheB to Its Chemoreceptor Substrate

mBio ◽  
2021 ◽  
Author(s):  
Mingshan Li ◽  
Xianjin Xu ◽  
Xiaoqin Zou ◽  
Gerald L. Hazelbauer
Keyword(s):  
Signal Transduction ◽  
Response Regulator ◽  
Response Regulators ◽  
Two Component ◽  
Primary Means ◽  
Two Component Signal Transduction ◽  
Sense And Respond ◽  
Signal Transduction Systems

Two-component signal transduction systems are a primary means by which bacteria sense and respond to their environment. Response regulators are key components of these systems.

scholarly journals Influence of Two-Component Signal Transduction Systems ofLactobacillus caseiBL23 on Tolerance to Stress Conditions

2010 ◽  
Vol 77 (4) ◽  
pp. 1516-1519 ◽  
Author(s):  
Cristina Alcántara ◽  
Ainhoa Revilla-Guarinos ◽  
Manuel Zúñiga
Keyword(s):  
Signal Transduction ◽  
Lactobacillus Casei ◽  
Stress Conditions ◽  
Response Regulators ◽  
Gene Encoding ◽  
Growth Defects ◽  
Two Component ◽  
Two Component Signal Transduction ◽  
Signal Transduction Systems

ABSTRACTLactobacillus caseiBL23 carries 17 two-component signal transduction systems. Insertional mutations were introduced into each gene encoding the cognate response regulators, and their effects on growth under different conditions were assayed. Inactivation of systems TC01, TC06, and TC12 (LCABL_02080-LCABL_02090, LCABL_12050-LCABL_12060, and LCABL_19600-LCABL_19610, respectively) led to major growth defects under the conditions assayed.

scholarly journals Comprehensive Studies of Drug Resistance Mediated by Overexpression of Response Regulators of Two-Component Signal Transduction Systems in Escherichia coli

2003 ◽  
Vol 185 (6) ◽  
pp. 1851-1856 ◽  
Author(s):  
Hidetada Hirakawa ◽  
Kunihiko Nishino ◽  
Takahiro Hirata ◽  
Akihito Yamaguchi
Keyword(s):  
Escherichia Coli ◽  
Signal Transduction ◽  
Drug Resistance ◽  
Response Regulator ◽  
Gene Knockout ◽  
Open Reading Frames ◽  
Two Component ◽  
Two Component Signal Transduction ◽  
Regulator Genes ◽  
Signal Transduction Systems

ABSTRACT In Escherichia coli, there are 32 open reading frames (ORFs) that are assumed to be response regulator genes of two-component signal transduction systems on the basis of sequence similarities. We cloned all of these 32 ORFs into a multicopy expression vector and investigated whether or not they confer drug resistance via control of drug resistance determinants. Fifteen of these ORFs, i.e., baeR, citB, cpxR, evgA, fimZ, kdpE, narL, narP, ompR, rcsB, rstA, torR, yedW, yehT, and dcuR, conferred increased single- or multidrug resistance. Two-thirds of them conferred deoxycholate resistance. Five of them, i.e., evgA, baeR, ompR, cpxR, and rcsB, modulated the expression of several drug exporter genes. The drug resistance mediated by evgA, baeR, and cpxR could be assigned to drug exporters by using drug exporter gene knockout strains.

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