Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers

1994 ◽  
Vol 33 (1) ◽  
pp. 91-101 ◽  
Author(s):  
L. Aguilar ◽  
C. Esteban ◽  
J. Frias ◽  
I. Pérez-Balcabao ◽  
A. J. Carcas ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
In Vitro Susceptibility ◽  
Serum Bactericidal Activity

scholarly journals Pharmacokinetics of sparfloxacin and serum bactericidal activity against pneumococci.

1996 ◽  
Vol 40 (3) ◽  
pp. 776-779 ◽  
Author(s):  
M Trautmann ◽  
M Ruhnke ◽  
K Borner ◽  
J Wagner ◽  
P Koeppe
Keyword(s):  
Bactericidal Activity ◽  
Geometric Mean ◽  
Clinical Situation ◽  
In Vitro Activity ◽  
Serum Bactericidal Activity ◽  
Time Period ◽  
Quinolone Antibiotics ◽  
Humoral Antibodies ◽  
Bactericidal Activities

Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the serum bactericidal activity of sparfloxacin against pneumococci in eight healthy, middle-aged volunteers. Pharmacokinetics in serum and urine after a 400-mg oral dose of sparfloxacin were comparable to those described by other authors. Inhibitory and bactericidal activities in serum were measured for four pneumococcal isolates representing penicillin-susceptible (one isolate), intermediately resistant (two isolates), and highly resistant (one isolate) strains. Geometric mean inhibitory titers ranged between 1:2.4 and 1:6.3 and bactericidal titers ranged between 1:1.3 and 1:3.6 during a time period of 1 to 6 h after drug intake. Although such titers were not sufficient to predict a clinical response based on previous pharmacodynamic studies using quinolone antibiotics, data obtained with volunteers may only partially reflect the clinical situation in which a rise of humoral antibodies directed against pneumococcal antigens may help to reinforce the bactericidal action of the antibiotic.

scholarly journals Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

1997 ◽  
Vol 41 (6) ◽  
pp. 1389-1391 ◽  
Author(s):  
L Aguilar ◽  
J Rosendo ◽  
I P Balcabao ◽  
M Martín ◽  
M J Giménez ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Phase I ◽  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
Resistant Strain ◽  
Phase I Study ◽  
Peak Level ◽  
Crossover Fashion ◽  
Activity Time ◽  
Serum Bactericidal Activity

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

scholarly journals Serum bactericidal activity of trovafloxacin, in combination with cefepime or amikacin, in healthy volunteers

2003 ◽  
Vol 9 (7) ◽  
pp. 670-677 ◽  
Author(s):  
A. Lubasch ◽  
S. Ziege ◽  
B. Brodersen ◽  
K. Borner ◽  
P. Koeppe ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Bactericidal Activity ◽  
Serum Bactericidal Activity
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