Comparative susceptibility of the Bacteroides fragilis group species and other anaerobic bacteria to meropenem, imipenem, piperacillin, cefoxitin, ampicillin/sulbactam, clindamycin and metronidazole

1993 ◽  
Vol 31 (3) ◽  
pp. 363-372 ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
Diane M. Citron ◽  
Charles E. Cherubin ◽  
Sharon L. Hillier
Keyword(s):  
Anaerobic Bacteria ◽  
Bacteroides Fragilis ◽  
Bacteroides Fragilis Group ◽  
Comparative Susceptibility ◽  
Group Species

scholarly journals In vitro activities of trovafloxacin against 557 strains of anaerobic bacteria.

1996 ◽  
Vol 40 (9) ◽  
pp. 2232-2235 ◽  
Author(s):  
H M Wexler ◽  
E Molitoris ◽  
D Molitoris ◽  
S M Finegold
Keyword(s):  
Antimicrobial Activity ◽  
Clinical Laboratory ◽  
Anaerobic Bacteria ◽  
Bacteroides Fragilis ◽  
National Committee ◽  
Dilution Technique ◽  
Agar Dilution ◽  
Group Species ◽  
Clostridium Spp

The antimicrobial activity of trovafloxacin for 557 strains of anaerobic bacteria was determined by the National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution technique. The species tested included Bacteroides fragilis (n = 91), other members of the B. fragilis group (n = 130), Campylobacter gracilis (n = 15), other Bacteroides spp. (n = 16), Prevotella spp. (n = 49), Porphyromonas spp. (n = 15), Fusobacterium spp. (n = 62), Bilophila wadsworthia (n = 24), Sutterella wadsworthensis (n = 21), Clostridium spp. (n = 61), Peptostreptococcus spp. (n = 38), and gram-positive non-spore-forming rods (n = 35). Trovafloxacin inhibited all strains of B. fragilis at < or = 0.5 microgram/ml, 99% of other B. fragilis group species at < or = 2 micrograms/ml, and 96% of all anaerobes tested at < or = 2 micrograms/ml.

scholarly journals Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group.

1997 ◽  
Vol 41 (9) ◽  
pp. 2047-2049 ◽  
Author(s):  
M E Falagas ◽  
L McDermott ◽  
D R Snydman
Keyword(s):  
Antimicrobial Susceptibility ◽  
Ph Effect ◽  
Geometric Mean ◽  
Bacteroides Fragilis ◽  
Acidic Ph ◽  
Effect Of Ph ◽  
Bacteroides Fragilis Group ◽  
Group Species

We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.

scholarly journals In Vitro Activity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group, Prevotella, Porphyromonas, and Veillonella Species

2020 ◽  
Vol 64 (9) ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
C. Vreni Merriam ◽  
Diane M. Citron
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Bacteroides Fragilis ◽  
Vitro Activity ◽  
Mixed Infections ◽  
In Vitro Activity ◽  
Content Type ◽  
Bacteroides Fragilis Group ◽  
Group Species

ABSTRACT Tedizolid’s anaerobic activity is unappreciated. In this study, it was active against all 332 anaerobic isolates tested at ≤2 μg/ml except Bilophila wadsworthia and was more active than linezolid against Bacteroides fragilis group species (MIC90, 1 μg/ml versus 2 to 4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC90 for clostridia, 0.25 to 1 μg/ml; MIC90 for anaerobic cocci, ≤0.06 to 0.25 μg/ml). Our data coupled with clinical reports indicate that clinicians should consider its use in mixed infections where Staphylococcus aureus and anaerobes are involved.

Identification and Strain Differentiation of 'Bacteroides fragilis Group' Species and Prevotella bivia by PCR Fingerprinting

Anaerobe ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 209-217 ◽  
Author(s):  
Marina Claros ◽  
G. Schönian ◽  
Y. Gräser ◽  
Th. Montag ◽  
A.C. Rodloff ◽  
...  
Keyword(s):  
Bacteroides Fragilis ◽  
Strain Differentiation ◽  
Pcr Fingerprinting ◽  
Prevotella Bivia ◽  
Bacteroides Fragilis Group ◽  
Group Species

Recovery of Bacteroides fragilis group from clinical specimens following antimicrobial therapy

1992 ◽  
Vol 38 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Itzhak Brook ◽  
Edith H. Frazier
Keyword(s):  
Antimicrobial Therapy ◽  
Recovery Rate ◽  
Inflammatory Process ◽  
Anaerobic Bacteria ◽  
Bacteroides Fragilis ◽  
Microbiology Laboratory ◽  
Pathogenic Role ◽  
Clinical Specimens ◽  
Bacteroides Fragilis Group ◽  
Bacteroides Ovatus

Over a period of 14 years (1973–1987), 3165 specimens submitted to the microbiology laboratory demonstrated the recovery of anaerobic bacteria. A total of 988 Bacteroides fragilis group isolates were recovered (0.3 isolates per specimen). Bacteroides fragilis accounted for 62% of the total of all B. fragilis group isolates, Bacteroides thetaiotaomicron for 15%, Bacteroides vulgatus for 8%, Bacteroides ovatus for 7%, Bacteroides distasonis for 6%, and Bacteroides uniformis for 2%. Of the 988 B. fragilis group isolates, 310 (31%) were recovered after the administration of antimicrobial therapy, and 129 (13%) were the single isolate recovered from the infected site at that time. The recovery rate of all members of B. fragilis group after the administration of antimicrobial therapy, when isolated alone or when mixed with other bacteria, was similar. The data illustrate the equal ability of all members of the B. fragilis group to persist in and to contribute to the inflammatory process; and provide further support for their pathogenic role. Key words: Bacteroides fragilis, bacteremia, abscesses, antimicrobials.

scholarly journals Surveillance of Antimicrobial Susceptibility of Anaerobe Clinical Isolates in Southeast Austria: Bacteroides fragilis Group Is on the Fast Track to Resistance

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 479
Author(s):  
Elisabeth König ◽  
Hans P. Ziegler ◽  
Julia Tribus ◽  
Andrea J. Grisold ◽  
Gebhard Feierl ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Anaerobic Bacteria ◽  
Bacteroides Fragilis ◽  
Beta Lactam ◽  
Gram Positive ◽  
Beta Lactam Antibiotics ◽  
Disk Diffusion Testing ◽  
Bacteroides Fragilis Group ◽  
Resistance Rates ◽  
Human Infections

Anaerobic bacteria play an important role in human infections. Bacteroides spp. are some of the 15 most common pathogens causing nosocomial infections. We present antimicrobial susceptibility testing (AST) results of 114 Gram-positive anaerobic isolates and 110 Bacteroides-fragilis-group-isolates (BFGI). Resistance profiles were determined by MIC gradient testing. Furthermore, we performed disk diffusion testing of BFGI and compared the results of the two methods. Within Gram-positive anaerobes, the highest resistance rates were found for clindamycin and moxifloxacin (21.9% and 16.7%, respectively), and resistance for beta-lactams and metronidazole was low (<1%). For BFGI, the highest resistance rates were also detected for clindamycin and moxifloxacin (50.9% and 36.4%, respectively). Resistance rates for piperacillin/tazobactam and amoxicillin/clavulanic acid were 10% and 7.3%, respectively. Two B. fragilis isolates were classified as multi-drug-resistant (MDR), with resistance against all tested beta-lactam antibiotics. The comparative study of 109 BFGI resulted in 130 discrepancies in 763 readings (17%) with a high number of Very Major Errors (VME) and Major Errors (ME). In summary, resistance rates, with the exception of clindamycin and moxifloxacin, are still low, but we are facing increasing resistance rates for BFGI. Surveillance studies on a regular basis are still recommended.

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