scholarly journals The Omega-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid (DHA) Reverses Corticosterone-Induced Changes in Cortical Neurons

2015 ◽  
pp. pyv130 ◽  
Author(s):  
Matteo M. Pusceddu ◽  
Yvonne M. Nolan ◽  
Holly F. Green ◽  
Ruairi C. Robertson ◽  
Catherine Stanton ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acid ◽  
Cortical Neurons ◽  
Omega 3 ◽  
Induced Changes

scholarly journals Use of Active Salmon-Lecithin Nanoliposomes to Increase Polyunsaturated Fatty Acid Bioavailability in Cortical Neurons and Mice

2021 ◽  
Vol 22 (21) ◽  
pp. 11859
Author(s):  
Elodie Passeri ◽  
Kamil Elkhoury ◽  
Maria Camila Jiménez Garavito ◽  
Frédéric Desor ◽  
Marion Huguet ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Cortical Neurons ◽  
Particle Surface ◽  
Standard Diet ◽  
Omega 3 ◽  
Rat Embryo ◽  
Negative Particle ◽  
Age Related ◽  
The Brain

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play an important role in the development, maintenance, and function of the brain. Dietary supplementation of n-3 PUFAs in neurological diseases has been a subject of particular interest in preventing cognitive deficits, and particularly in age-related neurodegeneration. Developing strategies for the efficient delivery of these lipids to the brain has presented a challenge in recent years. We recently reported the preparation of n-3 PUFA-rich nanoliposomes (NLs) from salmon lecithin, and demonstrated their neurotrophic effects in rat embryo cortical neurons. The objective of this study was to assess the ability of these NLs to deliver PUFAs in cellulo and in vivo (in mice). NLs were prepared using salmon lecithin rich in n-3 PUFAs (29.13%), and characterized with an average size of 107.90 ± 0.35 nm, a polydispersity index of 0.25 ± 0.01, and a negative particle-surface electrical charge (−50.4 ± 0.2 mV). Incubation of rat embryo cortical neurons with NLs led to a significant increase in docosahexaenoic acid (DHA) (51.5%, p < 0.01), as well as palmitic acid, and a small decrease in oleic acid after 72 h (12.2%, p < 0.05). Twenty mice on a standard diet received oral administration of NLs (12 mg/mouse/day; 5 days per week) for 8 weeks. Fatty acid profiles obtained via gas chromatography revealed significant increases in cortical levels of saturated, monounsaturated, and n-3 (docosahexaenoic acid,) and n-6 (docosapentaenoic acid and arachidonic acid) PUFAs. This was not the case for the hippocampus or in the liver. There were no effects on plasma lipid levels, and daily monitoring confirmed NL biocompatibility. These results demonstrate that NLs can be used for delivery of PUFAs to the brain. This study opens new research possibilities in the development of preventive as well as therapeutic strategies for age-related neurodegeneration.

scholarly journals Structural characterization of self-assemblies of new omega-3 lipids: docosahexaenoic acid and docosapentaenoic acid monoglycerides

2018 ◽  
Vol 20 (37) ◽  
pp. 23928-23941 ◽  
Author(s):  
Xianrong Shao ◽  
Gizem Bor ◽  
Sabah Al-Hosayni ◽  
Stefan Salentinig ◽  
Anan Yaghmur
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acid ◽  
Structural Characterization ◽  
Docosapentaenoic Acid ◽  
Omega 3

Hexosomes based on omega-3 polyunsaturated fatty acid monoglycerides.

scholarly journals Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats

2019 ◽  
Vol 9 ◽  
Author(s):  
Ameer Y. Taha ◽  
Marc-Olivier Trepanier ◽  
Flaviu A. Coibanu ◽  
Anjali Saxena ◽  
Melanie A. Jeffrey ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acid ◽  
Omega 3

Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10–12 years

2009 ◽  
Vol 12 (2) ◽  
pp. 48-56 ◽  
Author(s):  
David O. Kennedy ◽  
Philippa A. Jackson ◽  
Jade M. Elliott ◽  
Andrew B. Scholey ◽  
Bernadette C. Robertson ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Essential Fatty Acid ◽  
Healthy Children ◽  
Omega 3 ◽  
Mood Effects
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