scholarly journals Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure

2015 ◽  
Vol 18 (8) ◽  
Author(s):  
Matthew L. Banks ◽  
Blake A. Hutsell ◽  
Bruce E. Blough ◽  
Justin L. Poklis ◽  
S. Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Cocaine Addiction ◽  
Choice Procedure

scholarly journals Extinguishing cocaine-associated discriminative stimuli attenuates cocaine vs food choice in male rhesus monkeys

2019 ◽  
Author(s):  
Matthew L Banks ◽  
Blake A. Hutsell ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Fixed Ratio ◽  
Concurrent Schedule ◽  
Food Delivery ◽  
Self Administration ◽  
Discriminative Stimuli ◽  
Choice Procedure ◽  
Choice Procedures ◽  
Male Rhesus

ABSTRACTBackgroundIn drug addiction, relapse can be triggered by cues that function as discriminative stimuli to signal contingencies of drug availability and promote drug-taking behavior. Extinction procedures can weaken the association between drug-associated cues and drug use and may reduce the probability of relapse. This study evaluated effects of a regimen of extinction training on cocaine self-administration maintained in rhesus monkeys under a cocaine-vs.-food choice procedure that has been used previously to evaluate effectiveness of other candidate treatments for cocaine abuse.MethodsBehavior was initially maintained under a concurrent schedule of food delivery (1-g food pellets; fixed-ratio 100 schedule) and cocaine injections (0-0.1 mg/kg/injection; fixed-ratio 10 schedule) during daily 2-h choice sessions in male rhesus monkeys (n=4). Subsequently, choice sessions were supplemented by daily 20-h extinction sessions for 14 consecutive days. During extinction sessions, cocaine-associated discriminative stimuli were presented, but responding did not produce cocaine injections. Cocaine continued to be available during choice sessions.ResultsPrior to extinction, cocaine maintained a dose-dependent increase in cocaine vs. food choice. Responding during extinction sessions declined to low levels by the fifth day. Exposure to extinction sessions produced a more gradual but significant decline in cocaine choice and a complementary increase in food choice during choice sessions.ConclusionsThese preclinical results support the effectiveness of extinguishing cocaine-associated discriminative stimuli as a non-pharmacological treatment strategy for reducing cocaine choice. Moreover, these results also support the construct validity of preclinical drug vs. food choice procedures as a tool for candidate treatment evaluation for cocaine addiction.

scholarly journals Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys

2013 ◽  
Vol 38 (13) ◽  
pp. 2698-2707 ◽  
Author(s):  
Matthew L Banks ◽  
Bruce E Blough ◽  
Timothy R Fennell ◽  
Rodney W Snyder ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Extended Access

scholarly journals Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

2019 ◽  
Vol 44 (12) ◽  
pp. 2022-2029 ◽  
Author(s):  
E. Andrew Townsend ◽  
S. Stevens Negus ◽  
S. Barak Caine ◽  
Morgane Thomsen ◽  
Matthew L. Banks
Keyword(s):  
Sex Differences ◽  
Food Choice ◽  
Choice Procedure

Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure

1991 ◽  
Vol 104 (4) ◽  
pp. 515-521 ◽  
Author(s):  
J. D. Salamone ◽  
R. E. Steinpreis ◽  
L. D. McCullough ◽  
P. Smith ◽  
D. Grebel ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Food Consumption ◽  
Food Choice ◽  
Free Food ◽  
Dopamine Depletion ◽  
Novel Food ◽  
Choice Procedure ◽  
Lever Pressing

scholarly journals COCAINE VERSUS FOOD CHOICE PROCEDURE IN RATS: ENVIRONMENTAL MANIPULATIONS AND EFFECTS OF AMPHETAMINE

2013 ◽  
Vol 99 (2) ◽  
pp. 211-233 ◽  
Author(s):  
Morgane Thomsen ◽  
Andrew C. Barrett ◽  
S. Stevens Negus ◽  
S. Barak Caine
Keyword(s):  
Food Choice ◽  
Choice Procedure
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