scholarly journals Live birth rates after modified natural cycle compared with high-dose FSH stimulation using GnRH antagonists in poor responders

2015 ◽  
Vol 30 (10) ◽  
pp. 2321-2330 ◽  
Author(s):  
Trifon G. Lainas ◽  
Ioannis A. Sfontouris ◽  
Christos A. Venetis ◽  
George T. Lainas ◽  
Ioannis Z. Zorzovilis ◽  
...  
Keyword(s):  
Live Birth ◽  
Poor Responders ◽  
High Dose ◽  
Natural Cycle ◽  
Birth Rates ◽  
Gnrh Antagonists ◽  
Live Birth Rates

P–707 Does the dose or type of gonadotropin affect the reproductive outcomes of poor responders undergoing modified natural cycle IVF (MNC-IVF)?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
P Drakopoulos ◽  
L Boudry ◽  
S Mackens ◽  
M. D Vos ◽  
G Verheyen ◽  
...  
Keyword(s):  
Live Birth ◽  
Ovarian Response ◽  
Multivariate Regression Analysis ◽  
University Hospital ◽  
P Value ◽  
Poor Responders ◽  
Reproductive Outcomes ◽  
Birth Rates ◽  
Gnrh Antagonists ◽  
Live Birth Rates

Abstract Study question Does the dose or type of gonadotropin affect the reproductive outcomes of poor responders undergoing MNC-IVF? Summary answer Neither the type nor the dose of gonadotropins affects the reproductive outcomes of poor responders undergoing MNC-IVF. What is known already Poor ovarian response (POR) to ovarian stimulation remains a major therapeutic challenge in routine IVF practice, because of the association with low live birth rates and high cancellation rates. Although high doses of gonadotropins are traditionally used to stimulate the ovaries in women with predicted POR, MNC-IVF has been proposed as a mild-approach alternative in this population. Typically, the MNC protocol includes GnRH-antagonists to avoid premature ovulation and gonadotropin add-back stimulation at the late follicular phase. However, evidence is sparse, and there is no consensus regarding a specific dose or type of gonadotropins in this mild stimulation protocol. Study design, size, duration This is a retrospective cohort study including patients attending a tertiary referral University Hospital from 1st January 2017 until 1st March 2020. Participants/materials, setting, methods All women who underwent MNC-IVF in our center were included. Gonadotropins [recombinant FSH (rFSH), urinary FSH (uFSH) or highly purified human menopausal gonadotrophin (hp-hMG)] were started when a follicle with a mean diameter of 12–14 mm was observed on ultrasound scan, followed by GnRH antagonists (0.25mg/day) from the next day onwards. Mature oocytes were inseminated using ICSI. Main results and the role of chance In total, 484 patients undergoing 1398 cycles were included. Mean (SD) age and serum AMH were 38.2 (3.7) years and 0.46 (0.78) ng/ml, respectively. The daily dose of gonadotropins was either <75 IU/d [11/1398 (0.8%)] or 75 to < 100 IU/d [1303/1398 (93.2%)] or ≥ 100 IU/d [84/1398 (6%)]. Patients were stimulated with: rFSH [251/1398 (18%)], uFSH [45/1398 (3.2%)] or hp-hMG [1102/1398 (78.8%)]. Biochemical and clinical pregnancy rates were 142/1398 (10.1%) and 119/1398 (8.5%). Live birth was achieved in 80/1398 (5.7%) of cycles. Live birth rates (LBR) were similar between the different type and doses of gonadotropins (p-value 0.3 and 0.51, respectively). The GEE multivariate regression analysis adjusting for relevant confounders (age, BMI, number of MII oocytes) showed that the type of treatment strategy (rFSH/uFSH/hp-hMG) and the dose of gonadotropins were not significantly associated with LBR (coefficient 0.01 and –0.02, p value 0.09 and 0.3, respectively). Limitations, reasons for caution The main limitation is the retrospective design of our study, with an inherent risk of bias. Wider implications of the findings: This is the first and largest study evaluating MNC-IVF protocol modalities. Our data demonstrate that any type of gonadotropin can be used and there is no benefit from daily doses beyond 75IU. Trial registration number N/A

Live birth rates in Bologna poor responders treated with ovarian stimulation for IVF/ICSI

2014 ◽  
Vol 28 (4) ◽  
pp. 469-474 ◽  
Author(s):  
Nikolaos P. Polyzos ◽  
Milie Nwoye ◽  
Roberta Corona ◽  
Christophe Blockeel ◽  
Dominic Stoop ◽  
...  
Keyword(s):  
Live Birth ◽  
Ovarian Stimulation ◽  
Poor Responders ◽  
Birth Rates ◽  
Live Birth Rates

scholarly journals Live Birth Rates in Poor Responders’ Group after Previous Treatment with Autologous Platelet-Rich Plasma and Low Dose Ovarian Stimulation Compared with Poor Responders Used Only Low Dose Ovarian Stimulation Before in Vitro Fertilization

2019 ◽  
Vol 7 (19) ◽  
pp. 3184-3188 ◽  
Author(s):  
Snezhana Stojkovska ◽  
Gligor Dimitrov ◽  
Nikoleta Stamenkovska ◽  
Makuli Hadzi-Lega ◽  
Zoran Petanovski
Keyword(s):  
Live Birth ◽  
Ovarian Stimulation ◽  
Low Dose ◽  
Platelet Rich Plasma ◽  
Previous Treatment ◽  
Poor Responders ◽  
Birth Rates ◽  
Live Birth Rates ◽  
Autologous Platelet Rich Plasma

BACKGROUND: This prospective pilot study determined the efficacy of previous transvaginal intraovarian injection with autologous platelet-rich plasma (PRP) in poor ovarian responders (PORs) fulfilling the Bologna criteria before in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) with low dose ovarian stimulation. Current knowledge of efficient treatment for PORs is limited and often contradictory; also, LBRs of IVF remains disappointingly low. AIM: We assessed the live birth rates (LBRs) in PORs after previous ovarian treatment with PRP. METHODS: Overall, 40 patients undergoing IVF/ICSI between June 2017 ending December 2018 were included. A transvaginal intraovarian injection of PRP was performed on 20 patients. Both compered groups were balanced for all basic characteristics, and multivariate analysis was performed to adjust for all known confounders. RESULTS: Between the groups, a statistical significance in clinical pregnancies and LBR was not found. Clinical pregnancy and live birth rates were 33.33 ± 44.99 and 40.00 ± 50.71 in the PRP group and 10.71 ± 28.95 and 14.29 ± 36.31 in control group retrospectively. However, there is a trend towards higher implantation rates and LBRs in patients with previous treatment with PRP. Anyhow, the number of patients used in the research is insufficient to make a concrete conclusion, and more studies are needed in the future to confirm these results entirely. CONCLUSION: Even though the treatment of POR responders remains as a therapeutical challenge, the usage of intraovarian injection of autologous PRP in PORs before the IVF performance brings a glimpse of new hope in increasing the success of IVF defined by clinical pregnancy and LBRs.

scholarly journals Replacing single frozen-thawed euploid embryos in a natural cycle in ovulatory women may increase live birth rates compared to medicated cycles in anovulatory women

2017 ◽  
Vol 34 (10) ◽  
pp. 1325-1331 ◽  
Author(s):  
Alexis P Melnick ◽  
Robert Setton ◽  
Logan D. Stone ◽  
Nigel Pereira ◽  
Kangpu Xu ◽  
...  
Keyword(s):  
Live Birth ◽  
Natural Cycle ◽  
Birth Rates ◽  
Live Birth Rates

scholarly journals Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved

2015 ◽  
Vol 32 (5) ◽  
pp. 691-697 ◽  
Author(s):  
Ioannis A. Sfontouris ◽  
Efstratios M. Kolibianakis ◽  
George T. Lainas ◽  
Ram Navaratnarajah ◽  
Basil C. Tarlatzis ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Intracytoplasmic Sperm Injection ◽  
Poor Responders ◽  
Birth Rates ◽  
Vitro Fertilization ◽  
Live Birth Rates
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