scholarly journals Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats

2008 ◽  
Vol 24 (1) ◽  
pp. 154-165 ◽  
Author(s):  
Chie-Pein Chen ◽  
Shu-Hsiang Liu ◽  
Jian-Pei Huang ◽  
John D. Aplin ◽  
Yi-Hsin Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Placenta ◽  
In Utero ◽  
In Utero Transplantation

Experiences with In Utero Transplantation of Mesenchymal Stem Cells

2012 ◽  
pp. 161-168
Author(s):  
Carolyn Troeger ◽  
Irina Perahud ◽  
Eva Visca ◽  
Wolfgang Holzgreve
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
In Utero ◽  
In Utero Transplantation

Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses

2005 ◽  
Vol 192 (4) ◽  
pp. 1044-1052 ◽  
Author(s):  
Andreina Schoeberlein ◽  
Wolfgang Holzgreve ◽  
Lisbeth Dudler ◽  
Sinuhe Hahn ◽  
Daniel V. Surbek
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
In Utero ◽  
Tissue Specific ◽  
In Utero Transplantation

Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep

10.1038/81395 ◽  
2000 ◽  
Vol 6 (11) ◽  
pp. 1282-1286 ◽  
Author(s):  
Kenneth W. Liechty ◽  
Tippi C. MacKenzie ◽  
Aimen F. Shaaban ◽  
Antoneta Radu ◽  
AnneMarie B. Moseley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
In Utero ◽  
Site Specific ◽  
In Utero Transplantation ◽  
Specific Differentiation

Engraftment and differentiation of human mesenchymal stem cells after in utero transplantation in fetal sheep

2000 ◽  
Vol 191 (4) ◽  
pp. S96 ◽  
Author(s):  
Kenneth W Liechty ◽  
Tippi C Saydam ◽  
Aimen Shaaban ◽  
Ross Milner ◽  
AnneMarie B Moseley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
In Utero ◽  
Fetal Sheep ◽  
In Utero Transplantation

Tissue-specific engraftment of mesenchymal stem cells after in-utero transplantation in ovine fetuses

2004 ◽  
Vol 191 (6) ◽  
pp. S10
Author(s):  
Daniel Surbek ◽  
Andreina Schoeberlein ◽  
Lisbeth Dudler ◽  
Wolfgang Holzgreve
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
In Utero ◽  
Tissue Specific ◽  
In Utero Transplantation

scholarly journals IN UTERO TRANSPLANTATION OF HUMAN STEM CELLS USING AN ANIMAL MODEL: A COMPARISON BETWEEN TWO TECHNIQUES

2009 ◽  
Vol 15 (1) ◽  
pp. 5-10
Author(s):  
Daria GROZA ◽  
Emoke PALL ◽  
Mihai CENARIU ◽  
Raul POP ◽  
Nicolae Nicolae ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Loss Rate ◽  
Fetal Loss ◽  
In Utero ◽  
Needle Puncture ◽  
Ultrasound Guided ◽  
In Utero Transplantation ◽  
Blood Stem Cells ◽  
Cord Blood Stem Cells

Objective: The purpose of this study was to assess the feasibility of in utero stem cell transplantation of human umbilical cord blood stem cells in fetal sheep and to compare two different techniques of in utero transplantation, namely ultrasound-guided in utero transplantation and in utero transplantation after midline celiotomy. Study design: Umbilical cord blood units were collected from term deliveries, after obtaining written informed consent. Human cord blood–derived, CD34+ stem cells were injected into the peritoneal cavity of 60- to 65-day-old ovine fetuses by using 2 different techniques: ultrasound-guided transabdominal percutaneous needle puncture and midline celiotomy with the exposure of the pregnant uterus. Engraftment was determined after birth by flow cytometry with use of human-specific anti-CD 34/45 antibodies. Results: We obtained a total of 3 chimeric lambs. Using the midline celiotomy technique the fetal loss rate was 75% and only 33,3% when using ultrasound-guided transabdominal percutaneous needle puncture technique. Engraftment of donor cells was found in all fetuses, with a mean level of 1.4% in fetal peripheral blood and 3.3% in fetal bone marrow. Conclusion: This preliminary study indicates that in utero stem cell transplantation of human hematopoietic cord blood stem cells in fetal lambs is feasible and effective in terms of hematopoietic engraftment. We also concluded that the ultrasound-guided transabdominal percutaneous needle puncture technique is more effective than performing a midline celiotomy in terms of fetal loss rate.

scholarly journals Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes

2012 ◽  
Vol 64 (6) ◽  
pp. 701-710 ◽  
Author(s):  
Dongmei Zhang ◽  
Aiping Tong ◽  
Liangxue Zhou ◽  
Fang Fang ◽  
Gang Guo
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Human Placenta ◽  
Electrospun Nanofiber
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