scholarly journals Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation

2007 ◽  
Vol 22 (5) ◽  
pp. 1450-1456 ◽  
Author(s):  
O.P.Milling Smith ◽  
H.N. Jabbour ◽  
H.O.D. Critchley
Keyword(s):  
Enzyme Expression ◽  
Prostaglandin Receptor ◽  
Receptor Signalling

scholarly journals Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium

Reproduction ◽  
2003 ◽  
pp. 559-567 ◽  
Author(s):  
KJ Sales ◽  
HN Jabbour
Keyword(s):  
Reproductive Tract ◽  
Large Body ◽  
G Protein Coupled Receptors ◽  
Prostaglandin E ◽  
Bioactive Lipids ◽  
Prostaglandin Receptor ◽  
Receptor Signalling ◽  
G Protein Coupled ◽  
Endometrial Proliferation

Prostaglandins are bioactive lipids produced from arachidonic acid by cyclooxygenase (COX) enzymes and specific terminal prostanoid synthase enzymes. After biosynthesis, prostaglandins exert an autocrine-paracrine function by coupling to specific prostanoid G protein-coupled receptors to activate intracellular signalling and gene transcription. For many years, prostaglandins have been recognized as key molecules in reproductive biology by regulating ovulation, endometrial physiology and proliferation of endometrial glands and menstruation. More recently, a role for COX enzymes and prostaglandins has been ascertained in reproductive tract pathology, including carcinomas, menorrhagia, dysmenorrhoea and endometriosis. Although the mechanism by which prostaglandins modulate these pathologies is still unclear, a large body of evidence supports a role for COX enzymes, prostaglandins and prostaglandin receptor signalling pathways in angiogenesis, apoptosis and proliferation, tissue invasion and metastases and immunosuppression. Here, an overview is provided of some of the findings from these studies with specific emphasis on the role of COX enzymes, prostaglandin E(2) and F(2alpha) in disorders of endometrial proliferation and menstruation in non-pregnant women.

Contribution of retinoic acid receptor signalling to adrenal cortex morphology and functional zonation through modulation of WNT/[beta]-catenin pathway

2017 ◽  
Author(s):  
Zein Rami El ◽  
Amanda J Rickard ◽  
Golib Dzib Jose Felipe ◽  
Benoit Samson-Couterie ◽  
Angelique Rocha ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Beta Catenin ◽  
Acid Receptor ◽  
Receptor Signalling
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