scholarly journals Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

2012 ◽  
Vol 21 (22) ◽  
pp. 4980-4995 ◽  
Author(s):  
Maria N. Timofeeva ◽  
Rayjean J. Hung ◽  
Thorunn Rafnar ◽  
David C. Christiani ◽  
John K. Field ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Common Genetic Variation

scholarly journals Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study

2009 ◽  
Vol 69 (16) ◽  
pp. 6633-6641 ◽  
Author(s):  
Peter Broderick ◽  
Yufei Wang ◽  
Jayaram Vijayakrishnan ◽  
Athena Matakidou ◽  
Margaret R. Spitz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Genome Wide Association Study ◽  
Lung Cancer Risk ◽  
Genome Wide Association ◽  
Common Genetic Variation ◽  
Genome Wide ◽  
A Genome ◽  
The Impact

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

scholarly journals Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk

Cancer ◽  
2013 ◽  
Vol 119 (9) ◽  
pp. 1761-1761 ◽  
Author(s):  
Robert P. Young ◽  
Raewyn J. Hopkins
Keyword(s):  
Lung Cancer ◽  
Innate Immunity ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Lung Cancer Risk

scholarly journals Genetic Variation in BCL2 3′-UTR Was Associated with Lung Cancer Risk and Prognosis in Male Chinese Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72197 ◽  
Author(s):  
Ping Xu ◽  
Li Liu ◽  
Jianzhong Wang ◽  
Kai Zhang ◽  
Xiaohua Hong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Chinese Population ◽  
Lung Cancer Risk

scholarly journals Association of RASSF1A Promoter Methylation with Lung Cancer Risk: a Meta-analysis

2015 ◽  
Vol 15 (23) ◽  
pp. 10325-10328 ◽  
Author(s):  
Ying-Ze Huang ◽  
Wei Wu ◽  
Kun Wu ◽  
Xiao-Ning Xu ◽  
Wen-Ru Tang
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Promoter Methylation ◽  
Lung Cancer Risk ◽  
Meta Analysis

GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 6493-6500 ◽  
Author(s):  
Yan Zhao ◽  
Junjie Zeng ◽  
Yanxi Zhang ◽  
Su Lu ◽  
Erjiang Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
East Asian ◽  
Asian Populations ◽  
Gstm1 Polymorphism

scholarly journals The SNP rs402710 in 5p15.33 Is Associated with Lung Cancer Risk: A Replication Study in Chinese Population and a Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76252 ◽  
Author(s):  
Xuzai Lu ◽  
Juntao Ke ◽  
Xia Luo ◽  
Yaowu Zhu ◽  
Li Zou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Replication Study
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