scholarly journals Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis

2007 ◽  
pp. 59-71 ◽  
Author(s):  
Chikako Kiyohara ◽  
Kouichi Yoshimasu
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Nucleotide Excision Repair ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Meta Analysis ◽  
Repair Pathway ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Pathway

scholarly journals Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China

2005 ◽  
Vol 116 (5) ◽  
pp. 768-773 ◽  
Author(s):  
Min Shen ◽  
Sonja I. Berndt ◽  
Nathaniel Rothman ◽  
David M. DeMarini ◽  
Judy L. Mumford ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Nucleotide Excision Repair ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Xuan Wei ◽  
Repair Genes

scholarly journals Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk

2011 ◽  
Vol 33 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Kathryn Hughes Barry ◽  
Stella Koutros ◽  
Gabriella Andreotti ◽  
Dale P. Sandler ◽  
Laurie A. Burdette ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Nucleotide Excision Repair ◽  
Pesticide Exposure ◽  
Excision Repair ◽  
Prostate Cancer Risk ◽  
Repair Pathway ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Pathway

scholarly journals The association between polymorphisms in the DNA nucleotide excision repair genes and RRM1 gene and lung cancer risk

2012 ◽  
Vol 3 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Xuefei Li ◽  
Jie Zhang ◽  
Chunxia Su ◽  
Xinping Zhao ◽  
Liang Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Nucleotide Excision Repair ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Repair Genes

scholarly journals Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

2010 ◽  
Vol 2010 ◽  
pp. 1-17 ◽  
Author(s):  
Chikako Kiyohara ◽  
Koichi Takayama ◽  
Yoichi Nakanishi
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Repair Capacity ◽  
Repair Pathways

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR)=0.76, 95% confidence interval (CI)=0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.

Sign in / Sign up

Export Citation Format

Share Document