Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

Heather L. Montie; Maria S. Cho; Latia Holder; Yuhong Liu; Andrey S. Tsvetkov; Steven Finkbeiner; Diane E. Merry

doi:10.1093/hmg/ddp115

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

Human Molecular Genetics ◽

10.1093/hmg/ddp115 ◽

2009 ◽

Vol 18 (11) ◽

pp. 1937-1950 ◽

Cited By ~ 98

Author(s):

Heather L. Montie ◽

Maria S. Cho ◽

Latia Holder ◽

Yuhong Liu ◽

Andrey S. Tsvetkov ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Muscular Atrophy

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Soluble Androgen Receptor Oligomers Underlie Pathology in a Mouse Model of Spinobulbar Muscular Atrophy

Journal of Biological Chemistry ◽

10.1074/jbc.m609972200 ◽

2006 ◽

Vol 282 (5) ◽

pp. 3157-3164 ◽

Cited By ~ 65

Author(s):

Mei Li ◽

Erica S. Chevalier-Larsen ◽

Diane E. Merry ◽

Marc I. Diamond

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Muscular Atrophy ◽

Spinobulbar Muscular Atrophy

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Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy

Human Molecular Genetics ◽

10.1093/hmg/ddv300 ◽

2015 ◽

Vol 24 (21) ◽

pp. 5985-5994 ◽

Cited By ~ 34

Author(s):

Kentaro Sahashi ◽

Masahisa Katsuno ◽

Gene Hung ◽

Hiroaki Adachi ◽

Naohide Kondo ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Muscular Atrophy

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p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model

Journal of Neuroscience ◽

10.1523/jneurosci.3021-12.2013 ◽

2013 ◽

Vol 33 (18) ◽

pp. 7710-7727 ◽

Cited By ~ 42

Author(s):

H. Doi ◽

H. Adachi ◽

M. Katsuno ◽

M. Minamiyama ◽

S. Matsumoto ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Muscular Atrophy ◽

Inclusion Formation

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Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy

Human Molecular Genetics ◽

10.1093/hmg/ddl148 ◽

2006 ◽

Vol 15 (14) ◽

pp. 2225-2238 ◽

Cited By ~ 67

Author(s):

Patrick S. Thomas ◽

Gregory S. Fraley ◽

Vincent Damien ◽

Lillie B. Woodke ◽

Francisco Zapata ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Motor Neuron ◽

Muscular Atrophy ◽

Receptor Protein ◽

Motor Neuron Degeneration ◽

Neuron Degeneration ◽

Androgen Insensitivity ◽

Androgen Receptor Protein

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Heat Shock Protein 70 Chaperone Overexpression Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model by Reducing Nuclear-Localized Mutant Androgen Receptor Protein

Journal of Neuroscience ◽

10.1523/jneurosci.23-06-02203.2003 ◽

2003 ◽

Vol 23 (6) ◽

pp. 2203-2211 ◽

Cited By ~ 193

Author(s):

Hiroaki Adachi ◽

Masahisa Katsuno ◽

Makoto Minamiyama ◽

Chen Sang ◽

Gerassimos Pagoulatos ◽

...

Keyword(s):

Androgen Receptor ◽

Heat Shock ◽

Mouse Model ◽

Heat Shock Protein ◽

Transgenic Mouse ◽

Heat Shock Protein 70 ◽

Muscular Atrophy ◽

Transgenic Mouse Model ◽

Receptor Protein ◽

Androgen Receptor Protein

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Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy

Human Molecular Genetics ◽

10.1093/hmg/ddl226 ◽

2006 ◽

Vol 15 (19) ◽

pp. 2972-2972

Author(s):

Patrick S. Thomas ◽

Gregory S. Fraley ◽

Vincent Damian ◽

Lillie B. Woodke ◽

Francisco Zapata ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Motor Neuron ◽

Muscular Atrophy ◽

Receptor Protein ◽

Motor Neuron Degeneration ◽

Neuron Degeneration ◽

Androgen Insensitivity ◽

Androgen Receptor Protein

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Faculty Opinions recommendation of CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1084748.537661 ◽

2007 ◽

Author(s):

Valina Dawson

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Transgenic Mouse ◽

Muscular Atrophy ◽

Transgenic Mouse Model ◽

Receptor Protein ◽

Androgen Receptor Protein

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CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model

Journal of Neuroscience ◽

10.1523/jneurosci.1242-07.2007 ◽

2007 ◽

Vol 27 (19) ◽

pp. 5115-5126 ◽

Cited By ~ 105

Author(s):

H. Adachi ◽

M. Waza ◽

K. Tokui ◽

M. Katsuno ◽

M. Minamiyama ◽

...

Keyword(s):

Androgen Receptor ◽

Mouse Model ◽

Transgenic Mouse ◽

Muscular Atrophy ◽

Transgenic Mouse Model ◽

Receptor Protein ◽

Androgen Receptor Protein

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Faculty Opinions recommendation of Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.720225751.793502444 ◽

2014 ◽

Author(s):

Chris Henderson

Keyword(s):

Alternative Splicing ◽

Mouse Model ◽

Spinal Muscular Atrophy ◽

Muscular Atrophy ◽

Alternative Splicing Events

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Faculty Opinions recommendation of CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725275418.793502456 ◽

2014 ◽

Author(s):

Chris Henderson

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Spinal Muscular Atrophy ◽

Motor Function ◽

Muscular Atrophy ◽

Targeted Gene Therapy

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