scholarly journals Linkage of the Steroid Sulfatase Gene to the Sex-Reversed Mutation in the Mouse

Genetics ◽  
1987 ◽  
Vol 116 (3) ◽  
pp. 465-468
Author(s):  
Elisabeth A Keitges ◽  
Daniel F Schorderet ◽  
Stanley M Gartler
Keyword(s):  
Y Chromosome ◽  
Indirect Evidence ◽  
Male Meiosis ◽  
Steroid Sulfatase ◽  
Inheritance Pattern ◽  
Linkage Relationship ◽  
Relationship Of ◽  
Pairing Region

ABSTRACT Dosage studies and the inheritance pattern of the gene for steroid sulfatase (Sts) in the mouse have previously provided indirect evidence for a functional Y-linked allele which recombines obligatorily with its X-linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation (Sxr), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.

Mourning or early inadequate care? Reexamining the relationship of maternal loss in childhood with adult depression and anxiety

1992 ◽  
Vol 4 (3) ◽  
pp. 433-449 ◽  
Author(s):  
Antonia Bifulco ◽  
Tirrill Harris ◽  
George W. Brown
Keyword(s):  
Adult Life ◽  
Indirect Evidence ◽  
Early Death ◽  
High Rate ◽  
Adult Women ◽  
Depression And Anxiety ◽  
Adult Depression ◽  
Relationship Of ◽  
The Relationship

AbstractTwo population enquiries in Walthamstow and Islington, London, have shown that loss of the mother before the age of 17 years, either by death or separation for a year or more, doubles the risk of depressive and anxiety disorders among adult women. Furthermore, there was a particularly high rate of adult depression among those whose mothers died before they were 6 years old, and this was associated with a measure of childhood helplessness. There was no such link of either adult disorder or childhood helplessness with age at loss under 6 years for those losing a mother by separation. Two possible explanations were explored for these contrasting results. That concerning the adequacy of mourning of the mother's death received no support. However, evidence indicated that experience with the mother before the loss (usually affected by ongoing illness) explained the link of adult depression or anxiety with her early death. The failure of age at loss to relate in the separation group was probably due to the fact that among them age of separation was not a good indication of the quality of maternal care before age 6. Indirect evidence emerged which suggested that quality of early attachment (before age 6) to the natural mother before any loss relates to childhood helplessness. This in turn relates to a higher risk of disorder in adult life.

Linkage Relationship of C2 Deficiency, HLA and Glyoxalase I Loci

Vox Sanguinis ◽  
1979 ◽  
Vol 37 (6) ◽  
pp. 321-328 ◽  
Author(s):  
Maren L. Mahowald ◽  
Agustin P. Dalmasso ◽  
Robert A. Petzel ◽  
Edmond J. Yunis
Keyword(s):  
Glyoxalase I ◽  
Linkage Relationship ◽  
Relationship Of ◽  
C2 Deficiency

INHERITANCE AND LINKAGE RELATIONSHIP OF TWO RADIATION-INDUCED SEEDLING MUTANTS OF CUCUMBER

1973 ◽  
Vol 15 (3) ◽  
pp. 597-603 ◽  
Author(s):  
Ernest D. P. Whelan
Keyword(s):  
Cucumis Sativus ◽  
Recessive Gene ◽  
Single Recessive Gene ◽  
Linkage Relationship ◽  
Cucumis Sativus L ◽  
Gene Mutant ◽  
New Gene ◽  
Radiation Induced ◽  
Relationship Of ◽  
Pale Green

A radiation-induced mutation of cucumber (Cucumis sativus L.) which affects plant pubescence is controlled by a single recessive gene. Mutant seedlings have glabrous hynocotyls, and mature plants have glabrous internodes and leaf petioles. The laminae, especially of the first true leaf, the node areas and the perianths are slightly pubescent (glabrate). This new gene is designated glb, glabrate. There was no evidence of linkage between this gene and glabrous (gl), non-bitter cotyledon (bi), light sensitive (ls), yellow cotyledon (yc) or crinkled-leaf (cr).A sister line of glb also segregated for a lethal mutation. Mutant seedlings had pale green, slightly smaller cotyledons, and died 6 to 7 days after emergence. The mutation was controlled by a single recessive gene, designated pl, pale lethal. The gene was not linked with either glabrate (gib) or non-bitter cotyledon (bi).

Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant

1976 ◽  
Vol 14 (3-4) ◽  
pp. 373-381 ◽  
Author(s):  
Ralph H. Stern ◽  
Elizabeth S. Russell ◽  
Benjamin A. Taylor
Keyword(s):  
Strain Distribution ◽  
Linkage Relationship ◽  
Hemoglobin Variant ◽  
Relationship Of

scholarly journals Whole-Genome Sequencing Revealed a Late-Maturing Isogenic Rice Koshihikari Integrated with Hd16 Gene Derived from an Ise Shrine Mutant

2022 ◽  
Vol 2022 ◽  
pp. 1-12
Author(s):  
Motonori Tomita ◽  
Ryotaro Tokuyama ◽  
Shosuke Matsumoto ◽  
Kazuo Ishii
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Reference Genome ◽  
Recurrent Parent ◽  
Whole Genome ◽  
Linkage Relationship ◽  
Late Maturity ◽  
Key Genes ◽  
Late Maturation ◽  
Relationship Of

We identified the key genes controlling the late maturation of the Japonica cultivar Isehikari, which was found at Ise Jingu Shrine and matures 6 days later than Koshihikari. We conducted a genetics-based approach through this study. First, the latest mature plants, which flowered later than Isehikari, were segregated in the F2 and F3 generations of Koshihikari×Isehikari. Next, the linkage relationship of a single late-maturing gene with the SSR markers on the long arm of chromosome 3 was inferred by using late-maturing homozygous F2 segregants. Moreover, genetic analyses of late maturity were conducted through the process of six times of continuous backcross with Koshihikari as a recurrent parent by using the late-maturing homozygous F3 line as a nonrecurrent parent, thus developing a late-maturing isogenic Koshihikari (BC6F2). As a result, we elucidated a single late-maturing gene with incomplete dominance that caused the 14-day maturation delay of Koshihikari. The whole-genome sequencing was conducted on both of Koshihikari and the late-maturing isogenic Koshihikari. Then, the SNP call was conducted as the reference genome of Koshihikari. Finally, a single SNP was identified in the key gene Hd16 of the late-maturing isogenic Koshihikari.

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