MEIOTIC SEGREGATION AND MALE RECOMBINATION IN INTERSPECIFIC HYBRIDS OF DROSOPHILA

Genetics ◽  
1986 ◽  
Vol 114 (2) ◽  
pp. 485-494
Author(s):  
Jerry A Coyne
Keyword(s):  
Interspecific Hybrids ◽  
Meiotic Drive ◽  
Drosophila Species ◽  
Meiotic Segregation ◽  
Mendelian Segregation ◽  
Male Recombination ◽  
Genetic Elements ◽  
Transposable Genetic Elements

ABSTRACT Male hybrids between three pairs of Drosophila species show no substantial distortion of Mendelian segregation and no appreciable male recombination. These results do not support the theories that meiotic drive alleles of large effect are often fixed within species and that transposable genetic elements cause speciation.

scholarly journals A pooled sequencing approach identifies a candidate meiotic driver in Drosophila

2017 ◽  
Author(s):  
Kevin H-C Wei ◽  
Hemakumar M. Reddy ◽  
Chandramouli Rathnam ◽  
Jimin Lee ◽  
Deanna Lin ◽  
...  
Keyword(s):  
Telomere Length ◽  
Natural Populations ◽  
Meiotic Drive ◽  
Length Variation ◽  
Sequence Evolution ◽  
Nucleotide Polymorphisms ◽  
Mendelian Segregation ◽  
Transmission Frequency ◽  
Multiple Observations ◽  
Telomere Sequence

AbstractMeiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on genome evolution, but only a few drive loci of large effect have been described. New methods to reliably detect meiotic drive are therefore needed, particularly for discovering moderate-strength drivers that are likely to be more prevalent in natural populations than strong drivers. Here we report an efficient method that uses sequencing of large pools of backcross (BC1) progeny to test for deviations from Mendelian segregation genome-wide of single-nucleotide polymorphisms (SNPs) that distinguish the parental strains. We show that meiotic drive can be detected by a characteristic pattern of decay in distortion of SNP frequencies, caused by recombination unlinking the driver from distal loci. We further show that control crosses allow allele-frequency distortion caused by meiotic drive to be distinguished from distortion resulting from developmental effects. We used this approach to test whether chromosomes with extreme telomere-length differences segregate at Mendelian ratios, as telomeric regions are a potential hotspot for meiotic drive due to their roles in meiotic segregation and multiple observations of high rates of telomere sequence evolution. Using four different pairings of long and short telomere strains, we find no evidence that extreme telomere-length variation causes meiotic drive in Drosophila. However, we identify one candidate meiotic driver in a centromere-linked region that shows an ~8% increase in transmission frequency, corresponding to a ~54:46 segregation ratio. Our results show that candidate meiotic drivers of moderate strength can be readily detected and localized in pools of F1 progeny.

Transposition of mobile genetic elements in interspecific hybrids of Drosophila

Chromosoma ◽  
1982 ◽  
Vol 85 (3) ◽  
pp. 375-386 ◽  
Author(s):  
Michael B. Evgen'ev ◽  
Grigorii N. Yenikolopov ◽  
Natalya I. Peunova ◽  
Yuri V. Ilyin
Keyword(s):  
Interspecific Hybrids ◽  
Mobile Genetic Elements ◽  
Genetic Elements

Transposable Genetic Elements: The Mu Paradigm

1980 ◽  
pp. 81-92
Author(s):  
G. Chaconas ◽  
R.M. Harshey ◽  
M.S. DuBow ◽  
N. Sarvetnick ◽  
A.I. Bukhari
Keyword(s):  
Genetic Elements ◽  
Transposable Genetic Elements

On the evolution and population genetics of hybrid-dysgenesis-causing transposable elements in Drosophila

1986 ◽  
Vol 312 (1154) ◽  
pp. 205-215 ◽  
Keyword(s):  
Population Genetics ◽  
Natural Selection ◽  
Transposable Elements ◽  
Transposable Element ◽  
Natural Populations ◽  
Element Composition ◽  
Hybrid Dysgenesis ◽  
Evolutionary Significance ◽  
Genetic Elements ◽  
Transposable Genetic Elements

Much has been learned about transposable genetic elements in Drosophila , but questions still remain, especially concerning their evolutionary significance. Three such questions are considered here, (i) Has the behaviour of transposable elements been most influenced by natural selection at the level of the organism, the population, or the elements themselves? (ii) How did the elements originate in the genome of the species? (iii) Why are laboratory stocks different from natural populations with respect to their transposable element composition? No final answers to these questions are yet available, but by focusing on the two families of hybrid dysgenesis-causing elements, the P and I factors, we can draw some tentative conclusions.

Transposable genetic elements and plasmid evolution

Nature ◽  
1976 ◽  
Vol 263 (5580) ◽  
pp. 731-734 ◽  
Author(s):  
Stanley N. Cohen
Keyword(s):  
Plasmid Evolution ◽  
Genetic Elements ◽  
Transposable Genetic Elements
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