scholarly journals Editor’s Note: A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA

2021 ◽  
Vol 13 (6) ◽  
Keyword(s):  
Genetic Bottleneck

scholarly journals Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Mikael G. Pezet ◽  
Aurora Gomez-Duran ◽  
Florian Klimm ◽  
Juvid Aryaman ◽  
Stephen Burr ◽  
...  
Keyword(s):  
Germ Cell ◽  
Oxygen Tension ◽  
Germ Line ◽  
Embryonic Stem ◽  
Mitochondrial Diseases ◽  
Genetic Bottleneck ◽  
Cellular Mechanisms ◽  
Germ Cell Specification ◽  
Vitro Model

AbstractMost humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1–2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the amount of mtDNA within the developing female germ line appears to play a role, but other sub-cellular mechanisms have been implicated. Establishing an in vitro model of early mammalian germ cell development from embryonic stem cells, here we show that the reduction of mtDNA content is modulated by oxygen and reaches a nadir immediately before germ cell specification. The observed genetic bottleneck was accompanied by a decrease in mtDNA replicating foci and the segregation of heteroplasmy, which were both abolished at higher oxygen levels. Thus, differences in oxygen tension occurring during early development likely modulate the amount of mtDNA, facilitating mtDNA segregation and contributing to tissue-specific mutation loads.

Reliability of genetic bottleneck tests for detecting recent population declines

2012 ◽  
Vol 21 (14) ◽  
pp. 3403-3418 ◽  
Author(s):  
M. ZACHARIAH PEERY ◽  
REBECCA KIRBY ◽  
BRENDAN N. REID ◽  
RICKA STOELTING ◽  
ELENA DOUCET-BËER ◽  
...  
Keyword(s):  
Genetic Bottleneck ◽  
Population Declines

scholarly journals Looking Back for the Future: Utilizing Sawfish Saws from Natural History Collections to Conserve the Critically Endangered Largetooth Sawfish (Pristis pristis)

2018 ◽  
Vol 2 ◽  
pp. e25806
Author(s):  
Annmarie Fearing ◽  
Kelcee Smith ◽  
Tonya Wiley ◽  
Jeff Whitty ◽  
Kevin Feldheim ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Natural History ◽  
Mitochondrial Control Region ◽  
Genetic Bottleneck ◽  
Critically Endangered ◽  
Past Century ◽  
Term Survival ◽  
Tissue Samples ◽  
The Past ◽  
Natural History Collections

The Critically Endangered (International Union for Conservation of Nature) largetooth sawfish, Pristispristis, was historically distributed in the tropical Pacific, Atlantic and Indian Oceans. Today, ‘viable’ populations are largely limited to northern Australia. Populations that have suffered from drastic declines in abundance, such as those experienced by P.pristis, are typically at risk of having reduced, or low, levels of genetic diversity. Previous research found that P.pristis in Australia have experienced a genetic bottleneck, but it is unclear whether this bottleneck is the result of contemporary declines over the last century, or if it is the result of historic processes. A direct way to assess whether this genetic bottleneck occurred relatively recently is to compare levels of genetic diversity in contemporary and historic populations. Sawfish saws that were taken as trophies over the past century can now be found in natural history collections around the world and can provide DNA from past sawfish populations. We collected tissue samples from 150 dried P.pristis saws found in both private and public natural history collections. Because DNA from natural history specimens tends to be highly degraded, we targeted ten small DNA fragments, ~150 base pairs each, to amplify and sequence the entire mitochondrial control region. These data will provide important baseline information about P.pristis that can be used to quantify any loss of genetic diversity over the past ~100 years and assess their long-term survival potential. If the levels of genetic diversity in contemporary populations are severely reduced from those of past populations, protecting remaining genetic diversity within and between viable populations should be a priority in conservation plans.

scholarly journals Alive and kicking, or, living on borrowed time? – Microsatellite diversity in natural populations of the endangered Ulmus minor Mill. sensu latissimo from Croatia

2016 ◽  
Vol 75 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Marko Zebec ◽  
Marilena Idžojtić ◽  
Zlatko Šatović ◽  
Igor Poljak ◽  
Zlatko Liber
Keyword(s):  
Genetic Diversity ◽  
Natural Populations ◽  
Genetic Bottleneck ◽  
Dutch Elm Disease ◽  
Significant Excess ◽  
Mediterranean Populations ◽  
Ulmus Minor ◽  
Study Results ◽  
The Impact ◽  
Microsatellite Diversity

AbstractThe main objective of this research was to assess the genetic diversity of 5 natural field elm populations in Croatia. The study results suggest that the observed populations are characterized by a satisfactory amount of heterozygosity, and that the impact of the Dutch elm disease on the amount of genetic diversity in the sampled populations is currently negligible. However, one population displayed a significant excess of heterozygosity, implying a genetic bottleneck. The existence of a very clear genetic differentiation between the continental and the Mediterranean populations of Ulmus minor in Croatia was noticed.

scholarly journals Successful maintenance of a stingless bee population despite a severe genetic bottleneck

2010 ◽  
Vol 12 (3) ◽  
pp. 647-658 ◽  
Author(s):  
Denise Araujo Alves ◽  
Vera Lucia Imperatriz-Fonseca ◽  
Tiago Maurício Francoy ◽  
Pérsio Souza Santos-Filho ◽  
Johan Billen ◽  
...  
Keyword(s):  
Genetic Bottleneck ◽  
Stingless Bee

Genetic bottleneck in invasive species: the potato tuber moth adds to the list

2007 ◽  
Vol 10 (3) ◽  
pp. 319-333 ◽  
Author(s):  
N. Puillandre ◽  
S. Dupas ◽  
O. Dangles ◽  
J.-L. Zeddam ◽  
C. Capdevielle-Dulac ◽  
...  
Keyword(s):  
Invasive Species ◽  
Potato Tuber ◽  
Genetic Bottleneck ◽  
Potato Tuber Moth

The host acts as a genetic bottleneck during serial infections: an insect-fungal model system

2006 ◽  
Vol 50 (5) ◽  
pp. 335-345 ◽  
Author(s):  
Lisa R. Scully ◽  
Michael J. Bidochka
Keyword(s):  
Model System ◽  
Genetic Bottleneck

scholarly journals Conservation Genetic Assessment of Savannah Elephants (Loxodonta africana) in the Greater Kruger Biosphere, South Africa

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 779
Author(s):  
Santos ◽  
Fernandes ◽  
Henley ◽  
Dawson ◽  
Mumby
Keyword(s):  
Population Size ◽  
National Park ◽  
Genetic Bottleneck ◽  
Kruger National Park ◽  
Time Lags ◽  
Limited Information ◽  
Effective Population ◽  
Evolutionary Potential ◽  
Starting Point ◽  
Demographic Bottleneck

Savannah elephant populations have been severely reduced and fragmented throughout its remaining range. In general, however, there is limited information regarding their genetic status, which is essential knowledge for conservation. We investigated patterns of genetic variation in savannah elephants from the Greater Kruger Biosphere, with a focus on those in previously unstudied nature reserves adjacent to Kruger National Park, using dung samples from 294 individuals and 18 microsatellites. The results of genetic structure analyses using several different methods of ordination and Bayesian clustering strongly suggest that elephants throughout the Greater Kruger National Park (GKNP) constitute a single population. No evidence of a recent genetic bottleneck was detected using three moment-based approaches and two coalescent likelihood methods. The apparent absence of a recent genetic bottleneck associated with the known early 1900s demographic bottleneck may result from a combination of rapid post-bottleneck population growth, immigration and long generation time. Point estimates of contemporary effective population size (Ne) for the GKNP were ~ 500–700, that is, at the low end of the range of Ne values that have been proposed for maintaining evolutionary potential and the current ratio of Ne to census population size (Nc) may be quite low (<0.1). This study illustrates the difficulties in assessing the impacts on Ne in populations that have suffered demographic crashes but have recovered rapidly and received gene flow, particularly in species with long generation times in which genetic time lags are longer. This work provides a starting point and baseline information for genetic monitoring of the GKNP elephants.

scholarly journals Genetic consequences of a century of protection: serial founder events and survival of the little spotted kiwi ( Apteryx owenii )

2013 ◽  
Vol 280 (1762) ◽  
pp. 20130576 ◽  
Author(s):  
Kristina M. Ramstad ◽  
Rogan M. Colbourne ◽  
Hugh A. Robertson ◽  
Fred W. Allendorf ◽  
Charles H. Daugherty
Keyword(s):  
Genetic Variation ◽  
Long Island ◽  
Genetic Bottleneck ◽  
Island Population ◽  
Mating Pair ◽  
Terrestrial Vertebrates ◽  
Census Size ◽  
Single Mating ◽  
Genetic Bottlenecks ◽  
Founder Events

We present the outcome of a century of post-bottleneck isolation of a long-lived species, the little spotted kiwi ( Apteryx owenii , LSK) and demonstrate that profound genetic consequences can result from protecting few individuals in isolation. LSK were saved from extinction by translocation of five birds from South Island, New Zealand to Kapiti Island 100 years ago. The Kapiti population now numbers some 1200 birds and provides founders for new populations. We used 15 microsatellite loci to compare genetic variation among Kapiti LSK and the populations of Red Mercury, Tiritiri Matangi and Long Islands that were founded with birds from Kapiti. Two LSK native to D'Urville Island were also placed on Long Island. We found extremely low genetic variation and signatures of acute and recent genetic bottleneck effects in all four populations, indicating that LSK have survived multiple genetic bottlenecks. The Long Island population appears to have arisen from a single mating pair from Kapiti, suggesting there is no genetic contribution from D'Urville birds among extant LSK. The N e / N C ratio of Kapiti Island LSK (0.03) is exceptionally low for terrestrial vertebrates and suggests that genetic diversity might still be eroding in this population, despite its large census size.

Successful worldwide invasion of the veined rapa whelk, Rapana venosa, despite a dramatic genetic bottleneck

2018 ◽  
Vol 20 (11) ◽  
pp. 3297-3314 ◽  
Author(s):  
Dong-Xiu Xue ◽  
John Graves ◽  
Alvar Carranza ◽  
Sergiy Sylantyev ◽  
Sergey Snigirov ◽  
...  
Keyword(s):  
Genetic Bottleneck ◽  
Rapana Venosa ◽  
Rapa Whelk
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