scholarly journals Staphylococcal enterotoxin C2 as an adjuvant for rabies vaccine induces specific immune responses in mice

2018 ◽  
Vol 76 (5) ◽  
Author(s):  
Songyuan Yao ◽  
Yongqiang Li ◽  
Qianru Zhang ◽  
Huiwen Zhang ◽  
Libao Zhou ◽  
...  
Keyword(s):  
Immune Responses ◽  
Rabies Vaccine ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin C2

Microheterogeneity of staphylococcal enterotoxin C2

1975 ◽  
Vol 31 (2) ◽  
pp. 145-147 ◽  
Author(s):  
S. Stavric ◽  
H. Robern ◽  
N. Dickie
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin C2

Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2

2009 ◽  
Vol 83 (6) ◽  
pp. 1077-1084 ◽  
Author(s):  
Xiaogang Wang ◽  
Huiwen Zhang ◽  
Mingkai Xu ◽  
Changxiao Liu ◽  
Chenggang Zhang
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Deletion Mutants ◽  
Biological Analysis ◽  
Staphylococcal Enterotoxin C2

scholarly journals Recombinant Rabies Virus Overexpressing OX40-Ligand Enhances Humoral Immune Responses by Increasing T Follicular Helper Cells and Germinal Center B Cells

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 144 ◽  
Author(s):  
Yingying Li ◽  
Ling Zhao ◽  
Baokui Sui ◽  
Zhaochen Luo ◽  
Yachun Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Immune Responses ◽  
Rabies Virus ◽  
Germinal Center ◽  
Rabies Vaccine ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Follicular Helper ◽  
Ox40 Ligand

Rabies, caused by the rabies virus (RABV), remains a serious threat to public health in most countries. Development of a single-dose and efficacious rabies vaccine is the most important method to restrict rabies virus transmission. Costimulatory factor OX40-ligand (OX40L) plays a crucial role in the T cell-dependent humoral immune responses through T-B cell interaction. In this work, a recombinant RABV overexpressing mouse OX40L (LBNSE-OX40L) was constructed, and its effects on immunogenicity were evaluated in a mouse model. LBNSE-OX40L-immunized mice generated a larger number of T follicular helper (Tfh) cells, germinal center (GC) B cells, and plasma cells (PCs) than the parent virus LBNSE-immunized mice. Furthermore, LBNSE-OX40L induced significantly higher levels of virus-neutralizing antibodies (VNA) as early as seven days post immunization (dpi), which lasted for eight weeks, resulting in better protection for mice than LBNSE (a live-attenuated rabies vaccine strain). Taken together, our data in this study suggest that OX40L can be a novel and potential adjuvant to improve the induction of protective antibody responses post RABV immunization by triggering T cell-dependent humoral immune responses, and that LBNSE-OX40L can be developed as an efficacious and nonpathogenic vaccine for animals.

scholarly journals Identification of a Secondary Zinc-binding Site in Staphylococcal Enterotoxin C2

2003 ◽  
Vol 279 (2) ◽  
pp. 1297-1303 ◽  
Author(s):  
Anastassios C. Papageorgiou ◽  
Matthew D. Baker ◽  
Julie D. McLeod ◽  
Sayed K. Goda ◽  
Claire N. Manzotti ◽  
...  
Keyword(s):  
Binding Site ◽  
Staphylococcal Enterotoxin ◽  
Zinc Binding ◽  
Zinc Binding Site ◽  
Staphylococcal Enterotoxin C2

scholarly journals Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing

2018 ◽  
Vol 7 (2) ◽  
pp. 179-186
Author(s):  
T. Wu ◽  
J. Zhang ◽  
B. Wang ◽  
Y. Sun ◽  
Y. Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fracture Healing ◽  
Osteogenic Differentiation ◽  
Femoral Fracture ◽  
Staphylococcal Enterotoxin ◽  
Fracture Model ◽  
Local Administration ◽  
Staphylococcal Enterotoxin C2

Objectives As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized by Staphylococcus aureus, which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the in vivo effect of SCE2 on fracture healing. Materials and Methods Rat MSCs were used to test the effects of SEC2 on their proliferation and osteogenic differentiation potentials. A rat femoral fracture model was used to examine the effect of local administration of SEC2 on fracture healing using radiographic analyses, micro-CT analyses, biomechanical testing, and histological analyses. Results While SEC2 was found to have no effect on rat MSCs proliferation, it promoted the osteoblast differentiation of rat MSCs. In the rat femoral fracture model, the local administration of SEC2 accelerated fracture healing by increasing fracture callus volumes, bone volume over total volume (BV/TV), and biomechanical recovery. The SEC2 treatment group has superior histological appearance compared with the control group. Conclusion These data suggest that local administration of SEC2 may be a novel therapeutic approach to enhancing bone repair such as fracture healing. Cite this article: T. Wu, J. Zhang, B. Wang, Y. Sun, Y. Liu, G. Li. Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing. Bone Joint Res 2018;7:179–186. DOI: 10.1302/2046-3758.72.BJR-2017-0229.R1.

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