Microheterogeneity of staphylococcal enterotoxin C2

1975 ◽  
Vol 31 (2) ◽  
pp. 145-147 ◽  
Author(s):  
S. Stavric ◽  
H. Robern ◽  
N. Dickie
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin C2

Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2

2009 ◽  
Vol 83 (6) ◽  
pp. 1077-1084 ◽  
Author(s):  
Xiaogang Wang ◽  
Huiwen Zhang ◽  
Mingkai Xu ◽  
Changxiao Liu ◽  
Chenggang Zhang
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Deletion Mutants ◽  
Biological Analysis ◽  
Staphylococcal Enterotoxin C2

scholarly journals Identification of a Secondary Zinc-binding Site in Staphylococcal Enterotoxin C2

2003 ◽  
Vol 279 (2) ◽  
pp. 1297-1303 ◽  
Author(s):  
Anastassios C. Papageorgiou ◽  
Matthew D. Baker ◽  
Julie D. McLeod ◽  
Sayed K. Goda ◽  
Claire N. Manzotti ◽  
...  
Keyword(s):  
Binding Site ◽  
Staphylococcal Enterotoxin ◽  
Zinc Binding ◽  
Zinc Binding Site ◽  
Staphylococcal Enterotoxin C2

scholarly journals Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing

2018 ◽  
Vol 7 (2) ◽  
pp. 179-186
Author(s):  
T. Wu ◽  
J. Zhang ◽  
B. Wang ◽  
Y. Sun ◽  
Y. Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fracture Healing ◽  
Osteogenic Differentiation ◽  
Femoral Fracture ◽  
Staphylococcal Enterotoxin ◽  
Fracture Model ◽  
Local Administration ◽  
Staphylococcal Enterotoxin C2

Objectives As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized by Staphylococcus aureus, which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the in vivo effect of SCE2 on fracture healing. Materials and Methods Rat MSCs were used to test the effects of SEC2 on their proliferation and osteogenic differentiation potentials. A rat femoral fracture model was used to examine the effect of local administration of SEC2 on fracture healing using radiographic analyses, micro-CT analyses, biomechanical testing, and histological analyses. Results While SEC2 was found to have no effect on rat MSCs proliferation, it promoted the osteoblast differentiation of rat MSCs. In the rat femoral fracture model, the local administration of SEC2 accelerated fracture healing by increasing fracture callus volumes, bone volume over total volume (BV/TV), and biomechanical recovery. The SEC2 treatment group has superior histological appearance compared with the control group. Conclusion These data suggest that local administration of SEC2 may be a novel therapeutic approach to enhancing bone repair such as fracture healing. Cite this article: T. Wu, J. Zhang, B. Wang, Y. Sun, Y. Liu, G. Li. Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing. Bone Joint Res 2018;7:179–186. DOI: 10.1302/2046-3758.72.BJR-2017-0229.R1.

Functional analysis of the disulphide loop mutant of staphylococcal enterotoxin C2

2009 ◽  
Vol 82 (5) ◽  
pp. 861-871 ◽  
Author(s):  
Xiaogang Wang ◽  
Mingkai Xu ◽  
Yongming Cai ◽  
Hongli Yang ◽  
Huiwen Zhang ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin C2

Effect of staphylococcal enterotoxin C2 on the in vitro rates of protein and RNA synthesis by cow and buffalo liver

1989 ◽  
Vol 33 (3) ◽  
pp. 193-202
Author(s):  
R.I. Mashaly ◽  
M.G. El-Ziny ◽  
M.H. Salem ◽  
S.A. El-Deeb ◽  
A.A. Ismail
Keyword(s):  
Rna Synthesis ◽  
Staphylococcal Enterotoxin ◽  
Protein And Rna Synthesis ◽  
Staphylococcal Enterotoxin C2

scholarly journals Staphylococcal enterotoxin C2 expedites bone consolidation in distraction osteogenesis

2016 ◽  
Vol 35 (6) ◽  
pp. 1215-1225 ◽  
Author(s):  
Jia Xu ◽  
Tianyi Wu ◽  
Yuxin Sun ◽  
Bin Wang ◽  
Jinfang Zhang ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Staphylococcal Enterotoxin ◽  
Bone Consolidation ◽  
Staphylococcal Enterotoxin C2
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