scholarly journals The effects of alveolar decortications on orthodontic tooth movement and bone remodelling in rats

2017 ◽  
Vol 40 (4) ◽  
pp. 423-429 ◽  
Author(s):  
Eliane H Dutra ◽  
Ahmad Ahmida ◽  
Alexandro Lima ◽  
Sydney Schneider ◽  
Ravindra Nanda ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement

The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy

DENTA ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 34
Author(s):  
Arya Barahmanta ◽  
Muhammad Faizal Winaris ◽  
Pambudi Raharjo
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Therapy ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Pressure Area

<p><strong><em>Background:</em></strong><em> Orthodontic tooth movement is a </em><em>interaction prosess</em><em> of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO).  <strong>Purpose: </strong>To determine the difference number  of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. <strong>Materials and Methods</strong>: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male)  were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. <strong>Result:</strong> The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than  negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest  than positive control group (K+=3,83) and treatment (P=3,25). <strong>Conclusion: </strong>Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.</em></p><pre><strong> </strong></pre><p><strong><em>Keywords:</em></strong><em> Hyperbaric Oxygen, Tooth movement, Bone remodeling, </em><em>Osteocyte</em><em></em></p><p><em> </em></p><p><strong><em>Correspondence:</em></strong><em> </em><em>Arya Brahmanta</em><em>, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email:</em><em> </em><a href="mailto:[email protected]"><em>arya.brahmanta</em><em>@</em><em>hangtuah.ac.id</em></a></p>

scholarly journals Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
L. Feller ◽  
R. A. G. Khammissa ◽  
I. Schechter ◽  
G. Thomadakis ◽  
J. Fourie ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Review Article ◽  
Tissue Changes ◽  
Induced Stresses ◽  
Orthodontic Forces

Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting in bone formation, while mechanically induced compressive strains mediate predominantly catabolic tissue changes and bone resorption. In this review article we summarize some of the currently known biological events occurring in the periodontal ligament and in the alveolar bone in response to application of orthodontic forces and how these facilitate tooth movement.

scholarly journals Effects of mechanical strain on periodontal ligament fibroblasts in presence of Aggregatibacter actinomycetemcomitans lysate

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Agnes Schröder ◽  
Julia Stumpf ◽  
Eva Paddenberg ◽  
Patrick Neubert ◽  
Valentin Schatz ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Mechanical Strain ◽  
Orthodontic Tooth Movement ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Periodontal Ligament Fibroblasts ◽  
Reduced Pressure ◽  
Expression Of Genes ◽  
Ros Formation

Abstract Purpose Many adult orthodontic patients suffer from periodontitis, which is caused by oral pathogens such as the gram-negative Aggregatibacter actinomycetemcomitans (Agac). Like orthodontic tooth movement, periodontitis is associated with inflammation and alveolar bone remodelling thereby affecting orthodontic treatment. Interactions of both processes, however, are not sufficiently explored, particularly with regard to oxidative stress. Methods After preincubation with Agac lysate for 24 h periodontal ligament fibroblasts (PDLF) were either stretched or compressed for further 48 h simulating orthodontic forces in vitro. We analysed the expression of genes and proteins involved in the formation of reactive oxygen species (NOX-4, ROS) and nitric oxide (NOS-2), inflammation (TNF, IL-6, PTGS-2) and bone remodelling (OPG, RANKL). Results Agac lysate elevated the expression of NOX-4, NOS-2, inflammatory IL-6 and PTGS-2 and the bone-remodelling RANKL/OPG ratio during compressive, but not tensile mechanical strain. Agac lysate stimulated pressure-induced inflammatory signalling, whereas surprisingly ROS formation was reduced. Pressure-induced downregulation of OPG expression was inhibited by Agac lysate. Conclusions Agac lysate impact on the expression of genes and proteins involved in inflammation and bone remodelling as well as ROS formation, when PDLF were subjected to mechanical forces occurring during orthodontic tooth movement.

The effects of mandibular osteotomy on maxillary orthodontic tooth movement and bone remodelling in a rat model

2020 ◽  
Author(s):  
Yingchen Ji ◽  
Yi Tang ◽  
Qing Wu ◽  
Danqing Huang ◽  
Jie Zhu ◽  
...  
Keyword(s):  
Orthognathic Surgery ◽  
Tooth Movement ◽  
Volume Fraction ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tumour Necrosis Factor Receptor ◽  
Mandibular Osteotomy ◽  
The Third ◽  
Maxillary Tooth

Summary Objectives The accelerated tooth movement phenomenon after orthognathic surgery has been observed. However, the underlying mechanism remains unclear. There is no experimental study showing the effect of orthognathic surgery on orthodontic tooth movement of the opposing jaw. Therefore, the present study aimed at investigating if mandibular osteotomy enhances maxillary tooth movement and bone remodelling. Materials and methods Fifty-four male Sprague-Dawley rats were randomly divided into two groups: maxillary tooth movement (TM) and maxillary tooth movement + mandibular surgery (TM + MS). The orthodontic force was delivered to move the left maxillary first molar mesially. The surgical intervention was performed on the left mandible. Microcomputed tomography, histological analysis, enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction were used to assess changes at 3, 7, and 21 days after surgery. Results The mandibular osteotomy accelerates the rate of maxillary tooth movement with decreased bone volume fraction on the seventh day. Bone resorption was observed on the third and seventh day after mandibular osteotomy. It was found that serum interleukin-1β level increased significantly in the TM + MS group compared with the TM group, as well as the high expression level of cathepsin K and tumour necrosis factor receptor-associated factor 5 of the orthodontic tooth on the third and seventh day after mandibular osteotomy. Conclusion Data from the present study suggested that mandibular osteotomy accelerates maxillary osteoclast activity and post-operative tooth movement, providing evidence for accelerated tooth movement phenomenon after orthognathic surgery.

Biomarkers of orthodontic tooth movement with fixed appliances and vibration appliance therapy: a pilot study

2020 ◽  
Vol 42 (4) ◽  
pp. 378-386 ◽  
Author(s):  
Stacey Reiss ◽  
Marie Claude Chouinard ◽  
Dasha Frias Landa ◽  
Ravindra Nanda ◽  
Taranpreet Chandhoke ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Small Sample ◽  
Fixed Appliance ◽  
Time Points ◽  
Salivary Biomarkers ◽  
Anterior Teeth ◽  
Fixed Appliances ◽  
Time Point

Summary Introduction The aim of this study was to investigate the effect of supplemental vibratory force on biomarkers of bone remodelling during orthodontic tooth movement, the rate of mandibular anterior alignment (RMAA), and compliance with a vibration device. Design, settings, and participants Forty patients between the ages 15–35 undergoing fixed appliance treatment that presented to a university orthodontic clinic were randomly allocated to supplemental use of an intraoral vibrational device (n = 20, AcceleDent®) or fixed appliance only (n = 20). Salivary multiplex assay was completed to analyse the concentration of selected biomarkers of bone remodelling before treatment (T0) and at three following time points (T1, T2, T3), 4–6 weeks apart. Irregularity of the mandibular anterior teeth and compliance was assessed at the same trial time points. Data were analysed blindly on an intention-to-treat basis with descriptive statistics, Mann–Whitney U-test, Wilcoxon signed-rank test, and linear mixed effects regression modelling. Results No difference in the changes in salivary biomarkers of bone remodelling and RMAA between groups at any time point over the trial duration was observed. No correlation was found between changes in irregularity and biomarker level from baseline to another time point. Lastly, there was no association between RMAA and compliance with the AcceleDent® device. Conclusions Supplemental vibratory force during orthodontic treatment with fixed appliances does not affect biomarkers of bone remodelling or the RMAA. Limitations The main limitation of the study was the small sample size and the large variability in the salivary biomarkers. Harms No harms were observed during the duration of the trial. Protocol The protocol was not published prior to trial commencement. Registration The study was registered in Clinical Trials.gov (NCT02119455) first posted on April 2014.

scholarly journals Pengaruh faktor umur dan pemberian serbuk biji gandum terhadap jumlah osteoblas pada pergerakan gigi secara ortodontiThe effect of age and wheat seed powder application on the number of osteoblasts on orthodontic tooth movement

2020 ◽  
Vol 32 (3) ◽  
pp. 193
Author(s):  
Idayu Nafila ◽  
Putri Aulia Sari ◽  
Annisa Firdha ◽  
Sri Suparwitri
Keyword(s):  
Triticum Aestivum ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Coil Spring ◽  
Wheat Seed ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Maxillary Incisors ◽  
Effect Of Age

Pendahuluan: Pergerakan gigi pada perawatan ortodonti merupakan kombinasi proses resorpsi oleh osteoklas pada daerah tertekan dan aposisi oleh osteoblas pada sisi tertarik sehingga terjadi remodeling tulang. Remodeling tulang dipengaruhi umur dan hormon estrogen. Biji gandum (Triticum aestivum) merupakan fitoestrogen yang memiliki struktur dan fungsi seperti hormon estrogen. Tujuan penelitian menganalisis pengaruh faktor umur dan pemberian serbuk biji gandum terhadap jumlah osteoblas pada pergerakan gigi secara ortodonti pada tikus Sprague dawley muda dan tua. Metode: Jenis penelitian eksperimental laboratoris dengan menggunakan 36 subjek tikus Sprague dawley jantan yang terbagi menjadi kelompok muda (4-5 minggu) dan tua (18-20 minggu). Setiap grup akan dibagi menjadi 2 subgrup untuk menerima perlakuan yaitu: kelompok kontrol dengan perlakuan insisivus maksila digerakan ke distal menggunakan koil spring dan kelompok perlakuan yang diberi serbuk biji gandum dengan dosis 1,08 g dan perlakukan insisivus maksila digerakan ke distal menggunakan koil spring. Subjek hewan coba dieutanasia menggunakan anestesi dosis mematikan dan dilakukan pemotongan rahang atas pada regio kedua insisivus pada hari ke 1, 4, dan 7. Osteoblas dianalisis secara histologi dengan pengecatan hematoksilin eosin. Perhitungan jumlah osteoblas dilakukan dengan menggunakan mikroskop optilab. Hasil: Jumlah osteoblas kelompok muda lebih banyak dibandingkan kelompok tua. Pemberian serbuk biji gandum dapat meningkatkan jumlah osteoblas pada kelompok tua maupun muda. Pemberian serbuk biji gandum menunjukan pengaruh  signifikan p<0,001 (p<0,05) terhadap jumlah osteoblas Simpulan: Terdapat pengaruh faktor umur dan pemberian serbuk biji gandum terhadap peningkatan jumlah osteoblas pada pergerakan gigi secara ortodonti, osteoblas pada tikus berumur muda lebih banyak dibandingkan dengan tikus berumur tua.Kata kunci: Osteoblas, pergerakan gigi secara ortodonti, serbuk gandum, fitoestrogen, tikus Sprague dawley. ABSTRACTIntroduction: Tooth movement in orthodontic treatment is a combination of osteoclasts resorption in the stressed area and osteoblast apposition on the pulled side, resulting in bone remodelling. Bone remodelling is influenced by age and estrogen hormone. Wheat seeds (Triticum aestivum) are phytoestrogens with estrogen-like structure and function. This study was aimed to analyse the effect of age and wheat seed powder on the number of osteoblasts on orthodontic tooth movement in young and old Sprague-Dawley rats. Methods: This study was an experimental laboratory using 36 male Sprague-Dawley rats divided into young (4-5 weeks) and old (18-20 weeks) groups. Each group will be divided into two subgroups to receive treatment, namely: the control group with the treatment of the maxillary incisors moved distally using a coil spring and the treatment group treated with wheat seed powder at a dose of 1.08 g and treated the maxillary incisors were moved distally using a coil spring. Animal subjects were euthanised using lethal doses of anaesthesia, and the maxilla was cut in the second region of the incisors on the 1st, 4th, and 7th days. Osteoblasts were analysed histologically by eosin hematoxylin staining. The number of osteoblasts was calculated using an Optylab microscope. Results: The number of osteoblasts in the young group was found to be higher than the old group. The application of wheat seed powder can increase the number of osteoblasts in the young and old groups. The application of wheat seed powder showed a significant (p<0.001 (p<0.05)) on the number of osteoblasts. Conclusion: There was an effect of age and wheat seed powder on the increase in the number of osteoblasts on orthodontic tooth movement. The young rats have more osteoblasts compared to the old rats.Keywords: Osteoblasts, orthodontic tooth movement, wheat seed powder, phytoestrogen, Sprague-Dawley rats.

A BONE REMODELLING MODEL FOR LONG TERM ORTHODONTIC TOOTH MOVEMENT

2012 ◽  
Vol 45 ◽  
pp. S180
Author(s):  
Marlène Mengoni ◽  
Vinciane d'Otreppe ◽  
Jean-Philippe Ponthot
Keyword(s):  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement

scholarly journals The role of cytokines in orthodontic tooth movement

2012 ◽  
Vol 140 (5-6) ◽  
pp. 371-378 ◽  
Author(s):  
Nadezda Milosevic-Jovcic ◽  
Amila Vujacic ◽  
Aleksandra Konic ◽  
Jasna Pavlovic ◽  
Vera Todorovic ◽  
...  
Keyword(s):  
Early Phase ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Current Knowledge ◽  
Orthodontic Tooth Movement ◽  
Surrounding Tissue ◽  
Bone Biology ◽  
The Subject

One of the most important breakthroughs in the understanding of bone biology was the identification of the role of cytokines in bone remodelling including the alveolar bone exposed to the effect of mechanical forces during orthodontic treatment. Since bone remodelling is associated, in its early phase, with inflammation of the surrounding tissue, the hypothesis has been suggested on the role of proinflammatory cytokines in the process of bone remodelling, primarily IL-1?, IL-6 and TNF- ?. These cytokines function as response mediators in the acute phase of inflammation, as well as in the processes of metabolism, and stimulation of resorption and inhibition of bone formation. Mostly uninvestigated, the dynamics of concurrent changes of these three cytokines during the early phase of orthodontic teeth movement in children and adults was the subject of our investigation presented in this article on the current knowledge on the role of cytokines in this process.

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