scholarly journals Biological Activities of Chinese Propolis and Brazilian Propolis on Streptozotocin-Induced Type 1 Diabetes Mellitus in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Zhu ◽  
Minli Chen ◽  
Qiyang Shou ◽  
Yinghua Li ◽  
Fuliang Hu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Biological Activities ◽  
Total Cholesterol Level ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Brazilian Propolis ◽  
Chinese Propolis

Propolis is a bee-collected natural product and has been proven to have various bioactivities. This study tested the effects of Chinese propolis and Brazilian propolis on streptozotocin-induced type 1 diabetes mellitus in Sprague-Dawley rats. The results showed that Chinese propolis and Brazilian propolis significantly inhibited body weight loss and blood glucose increase in diabetic rats. In addition, Chinese propolis-treated rats showed an 8.4% reduction of glycated hemoglobin levels compared with untreated diabetic rats. Measurement of blood lipid metabolism showed dyslipidemia in diabetic rats and Chinese propolis helped to reduce total cholesterol level by 16.6%. Moreover, oxidative stress in blood, liver and kidney was improved to various degrees by both Chinese propolis and Brazilian propolis. An apparent reduction in levels of alanine transaminase, aspartate transaminase, blood urea nitrogen and urine microalbuminuria-excretion rate demonstrated the beneficial effects of propolis in hepatorenal function. All these results suggested that Chinese propolis and Brazilian propolis can alleviate symptoms of diabetes mellitus in rats and these effects may partially be due to their antioxidant ability.

scholarly journals Skin oxygenation impairment is associated with increased total cholesterol level in children with short-lasting type 1 diabetes mellitus

2021 ◽  
Vol 38 (4) ◽  
pp. 615-621
Author(s):  
Jolanta Neubauer-Geryk ◽  
Melanie Wielicka ◽  
Grzegorz M. Kozera ◽  
Agnieszka Brandt-Varma ◽  
Anna Wołoszyn-Durkiewicz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Oxygenation Impairment

scholarly journals The Role of Epoxyeicosatrienoic Acids in Diabetes Mellitus-Induced Impaired Vascular Relaxation of Aortic Rings in Ovariectomized Sprague-Dawley Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Dragan Manojlović ◽  
Ana Stupin ◽  
Anita Matić ◽  
Zrinka Mihaljević ◽  
Sanja Novak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Mrna Expression ◽  
Vascular Function ◽  
Diabetic Rats ◽  
Ovariectomized Rats ◽  
Aortic Tissue ◽  
Sprague Dawley ◽  
Sd Rats

Aim. The present study was aimed at determining if type 1 diabetes mellitus (DM) affects vascular function and at elucidating the mechanisms mediating vasorelaxation in both nonovariectomized and ovariectomized Sprague-Dawley (SD) rats. Materials and Methods. Eighty female SD rats were divided into four groups: nonovariectomized healthy (non-OVX-CTR) and diabetic (non-OVX-DM) rats and ovariectomized healthy (OVX-CTR) and diabetic (OVX-DM) rats. Bilateral ovariectomy was performed at the age of 5 weeks, and type 1 DM was induced by streptozotocin at the age of 6 weeks. At the age of 12 weeks, acetylcholine-induced relaxation (AChIR) was assessed in aortic rings in the absence/presence of L-NAME, Indomethacin, and MS-PPOH. Aortic tissue mRNA expression of eNOS, iNOS, COX-1, COX-2, thromboxane synthase 1 (TBXAS1), CYP4A1, CYP4A3, and CYP2J3, as well as plasma oxidative stress, was measured. Results. AChIR did not differ in non-OVX-DM rats compared to non-OVX-CTR ones. AChIR was significantly reduced in the OVX-DM group compared to the OVX-CTR group. MS-PPOH did not reduce AChIR in OVX-DM rats as it did in OVX-CTR ones. CYP4a3 mRNA expression in OVX-DM rats was significantly lower compared to that in the OVX-CTR group. Conclusions. Female sex hormones may protect vasorelaxation in type 1 diabetic rats. Type 1 diabetes impairs vasorelaxation in response to ACh in ovariectomized rats (but not in nonovariectomized rats) by affecting vasorelaxation pathways mediated by EETs.

scholarly journals Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus

2019 ◽  
Vol 6 (13) ◽  
pp. 331-345 ◽  
Author(s):  
Mayane Oliveira Rebouças da Silveira ◽  
Liliany Souza de Brito Amaral ◽  
Samira Itana de Souza ◽  
Halanna Rocha Ferraz ◽  
Jéssica Alves Dias ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Renal Function ◽  
Aerobic Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Rats ◽  
Ovariectomized Rats ◽  
And Oxidative Stress

This study evaluated the aerobic exercise effects of moderate and progressive intensity on renal function and structure, and oxidative stress in ovariectomized rats with type 1 diabetes mellitus induced by streptozotocin (STZ). Eighteen Wistar rats were divided into 3 groups: OSC - ovariectomized and sedentary control rats; OSD - ovariectomized and sedentary diabetic rats; and OTD - ovariectomized and trained diabetic rats. After induction of diabetes, the OTD group was submitted to eight weeks of exercise. Twenty-four hours after the last training session urine samples were collected. Blood samples and kidneys were collected after euthanasia for renal function analysis, histology, morphometry and oxidative stress. Our results have shown a reduction of the weight gain, increase of kidney weight and postprandial glycemia in diabetic rats. However, exercise decreased glycosuria and prevented the proteinuria in OTD group rats. Focal segmental glomerulosclerosis (FSGS), juxtamedullary glomerular tuft area, tubulointerstitial lesions (TIL), brush border loss and tubular cell debridement were reduced in OTD rats. In addition, exercise training decreased urinary and plasma concentrations of thiobarbituric acid reactive substance (TBARS). Our results demonstrate the beneficial effect of progressive aerobic exercise on proteinuria, glycosuria, and renal structure in ovariectomized diabetic rats, which may be mediated in part by reduction of oxidative stress.

scholarly journals INFLUENCE OF N-ACETYLCYSTEINE AND LOSARTAN ON THE EARLY ELECTROCARDIOGRAPHIC CHANGES IN RATS WITH STREPTOZOTOCIN TYPE 1 DIABETES MELLITUS

2016 ◽  
pp. 5-11
Author(s):  
I. Sytnyk ◽  
M. Khaitovych ◽  
N. Chernovol
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Heart Rhythm ◽  
Diabetic Rats ◽  
P Wave ◽  
Standard Lead ◽  
Electrocardiographic Changes ◽  
Ventricular Depolarization

Aim. To determine the early electrocardiographic onset of experimental diabetic cardiomyopathy (DC) in rats and evaluate its changes under the exposure to N- acetylcysteine and losartan. Materials and methods. Type 1 diabetes mellitus (DM1) in rats was induced by using streptozotocin (STZ) in a dose of 50mg/kg. Experimental animals were divided into 5 groups: control (intact animals which were administered placebo -saline as vehicle); DM1 (group of model animals with STZ DM1); NAC (diabetic rats which were administered N-acetylcysteine in a dose of 1,5g/kg per os); LOS (diabetic rats which were administered losartan in a dose of 20mg/kg per os); NAC+LOS (diabetic rats which were administered combination of N- acetylcysteine and losartan). ECG was registered in II standard lead. Results. On the 1-st week of STZ DM1 we didn't observe significant changes in rats. It was determined that due to stable hyperglycemia starting from 2-d experimental week occur the early ECG changes, which were characterized by lowering of heart rate, alteration of P wave, prolongation of QTc, decreasing of T wave, which pointed at impairment of ventricular repolarization. More significant differences were observed on 4-5 week of experimental DM1, to specified challenges were added bradycardia progression, deterioration of AV conduction and ventricular depolarization. All of the pharmacological schemes have indicated positive response on heart rhythm, ventricular contractive activity and hypertrophy challenge. More evident influence after 5 weeks of STZ DM1 was obtained for NAC, which possible due to its antioxidant action, decrease hyperglycemia-induced manifestation of DC. Conclusion. Administration of NAC and LOS on the early stages of DC manifestation prevent disturbance of heart rhythm, ventricular depolarization and repolarization as well as inhibiting hypertrophy development, minimizing risk for sudden cardiac death.

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