scholarly journals Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine: A Randomized Placebo-Controlled Pilot Clinical Study

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Wan Fung Kum ◽  
Siva Sundara Kumar Durairajan ◽  
Zhao Xiang Bian ◽  
Sui Cheung Man ◽  
Yuen Chi Lam ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Study ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Conventional Therapy ◽  
Idiopathic Parkinson’S Disease ◽  
Chinese Herbal ◽  
Idiopathic Parkinson's Disease ◽  
Sf 36

The objective of this clinical study is to examine the effects of a Chinese herbal medicine formula (Jia Wei Liu Jun Zi Tang: JWLJZT) on motor and non-motor symptoms, and on complications of conventional therapy in idiopathic Parkinson's disease (PD), using an add-on design. Fifty-five patients with PD were randomly allocated to receive either Chinese herbal medicine or placebo for 24 weeks. Primary outcome measure was the 39-item Parkinson's Disease Questionnaire (PDQ-39). Secondary outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), Short-Form-36 Health Survey (SF-36), Geriatric Depression Scale (GDS), home diaries, and a range of category rating scales.JWLJZTresulted in a significant improvement in the UPDRS IVC when compared with placebo at 12 weeks (P= .039) and 24 weeks (P= .034). In addition, patients in the Chinese herbal medicine group also showed significant improvement in PDQ-39 communication scores at 12 weeks (P= .024) and 24 weeks (P= .047) when compared with the placebo group. There were no significant differences between treatment and control groups for SF-36 variables, GDS score or the mean daily “on-off” time. One case of mild diarrhea was noted in the treatment group. The findings suggest thatJWLJZTcan relieve some non-motor complications of conventional therapy and improve the communication ability in patients with PD. The results of this pilot study warrant larger multi-center clinical studies to assess long-term efficacy and tolerability ofJWLJZT, and to elucidate the mechanisms by which it affects PD function.

scholarly journals Pharmacoacupuncture for Idiopathic Parkinson’s Disease: A Systematic Review of Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ki-Ho Cho ◽  
Tae-Hun Kim ◽  
Woo-Sang Jung ◽  
Sang-Kwan Moon ◽  
Chang-Nam Ko ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Conventional Therapy ◽  
Acupuncture Points ◽  
Controlled Trials ◽  
Idiopathic Parkinson’S Disease ◽  
Randomized Controlled ◽  
Idiopathic Parkinson's Disease

Introduction. Pharmacoacupuncture is a new acupuncture treatment that stimulates acupuncture points by injecting herbal medicine into them. Recently, pharmacoacupuncture has been widely used in the treatment of idiopathic Parkinson’s disease in traditional East Asian medicine. The purpose of this systematic review is to evaluate the efficacy and safety of pharmacoacupuncture in the treatment of idiopathic Parkinson’s disease. Methods. The following electronic databases were searched for studies published in or before December 2016: Medline, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, OASIS, and CNKI, without language restriction. The main outcome assessed was the total Unified Parkinson’s Disease Rating Scale (UPDRS) score. The details of the pharmacoacupuncture intervention, such as the herbal medicine and acupuncture points used, were also investigated. Results. From 138 studies, 3 randomized controlled trials were included; the number of patients analyzed was 134. Most of the studies showed considerable methodological flaws. There was heterogeneity of the intervention type and treatment duration in the included studies. Therefore, we could not conduct a meta-analysis. In one study, adjunctive bee venom pharmacoacupuncture therapy significantly improved total UPDRS scores compared with conventional therapy alone. Another study, which used adjunctive Kakkonein pharmacoacupuncture, did not reveal significant improvement compared with conventional therapy alone. A third study reported that Mailuoning pharmacoacupuncture was able to significantly improve the modified Webster Symptom Score when compared with no treatment. Adverse events related to the pharmacoacupuncture were reported in only one case, itching caused by the bee venom. Conclusions. Our findings regarding the efficacy of pharmacoacupuncture as a therapy for idiopathic Parkinson’s disease are currently inconclusive. Further large and rigorous clinical trials are needed.

scholarly journals Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Yan Wang ◽  
Cheng-Long Xie ◽  
Lin Lu ◽  
Deng-Lei Fu ◽  
Guo-Qing Zheng
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Adjuvant Therapy ◽  
Adverse Effects ◽  
Chinese Herbal Medicine ◽  
Conventional Treatment ◽  
Rating Scale ◽  
Meta Analysis ◽  
Chinese Herbal

Parkinson's disease (PD) is a common and debilitating neurodegenerative disorder that needs long-term levodopa administration and can result in progressive deterioration of body functions, daily activities and participation. The objective of this meta-analysis evaluates the clinical efficacy and safety of Chinese herbal medicine (CHM) as an adjunct therapy for PD patients. Methodological issues include a systematic literature search between 1950 and April 2011 to identify randomized trials involving CHM adjuvant therapy versus western conventional treatment. The outcome measures assessed were the reduction in scores of Unified Parkinson's Disease Rating Scale (UPDRS) and adverse effects. 19 trials involving 1371 participants were included in the meta-analysis. As compared to western conventional treatment, CHM adjuvant therapy resulted in greater improvement in UPDRS I, II, III, IV scores, and UPDRS I–IV total scores (P<0.001). Adverse effects were reported in 9 studies. The side effects in CHM adjuvant therapy group were generally less than or lighter than the conventional treatment group. In conclusion, CHM adjuvant therapy may potentially alleviate symptoms of PD and generally appeared to be safe and well tolerated by PD patients. However, well-designed, randomized, placebo-controlled clinical trials are still needed due to the generally low methodological quality of the included studies.

Utilization of Chinese herbal medicine and its association with the risk of fracture in patients with Parkinson's disease in Taiwan

2018 ◽  
Vol 226 ◽  
pp. 168-175 ◽  
Author(s):  
Kuan-Yu Chen ◽  
Mei-Yao Wu ◽  
Pei-Shan Yang ◽  
Jen-Huai Chiang ◽  
Chung-Y. Hsu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Risk Of Fracture ◽  
Chinese Herbal
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