scholarly journals Wound Healing Activity of Topical Application Forms Based on Ayurveda

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Hema Sharma Datta ◽  
Shankar Kumar Mitra ◽  
Bhushan Patwardhan
Keyword(s):  
Wound Healing ◽  
Mechanical Strength ◽  
Seed Oil ◽  
Breaking Strength ◽  
Wound Contraction ◽  
Collagen Content ◽  
Tissue Cell ◽  
Cell Regeneration ◽  
Flax Seed ◽  
Shorea Robusta

The traditional Indian medicine—Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil,Phyllanthus emblicafruits,Shorea robustaresin,Yashada bhasmaas study materials. For preliminary efficacy evaluation of the anti-aging activity we chose excision and incision wound healing animal models and studied the parameters including wound contraction, collagen content and skin breaking strength which in turn is indicative of the tissue cell regeneration capacity, collagenation capacity and mechanical strength of skin. The group treated with the formulations containingYashada bhasmaalong withShorea robustaresin and flax seed oil showed significantly better wound contraction (P < .01), higher collagen content (P < .05) and better skin breaking strength (P < .01) as compared to control group; thus proposing them to be effective prospective anti-aging formulations.

scholarly journals Experimental Evaluation of Ethanolic Extract ofCarapa guianensisL. Leaf for Its Wound Healing Activity Using Three Wound Models

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
B. Shivananda Nayak ◽  
Joel Kanhai ◽  
David Malcolm Milne ◽  
Lexley Pinto Pereira ◽  
William H. Swanston
Keyword(s):  
Wound Healing ◽  
Drinking Water ◽  
Granulation Tissue ◽  
Dead Space ◽  
Breaking Strength ◽  
Test Group ◽  
Ethanolic Extract ◽  
Wound Contraction ◽  
Hydroxyproline Content ◽  
Wound Healing Activity

The leaves ofCarapa guianensishave been used to treat ulcers, skin parasites, and skin problems. The ethanolic extract ofC. guianensisleaf was evaluated for its antibacterial and wound healing activity using excision, incision and dead space wound models in rats. The animals were randomly divided into two groups (n= 6) in all the models. In the excision wound model test group animals were treated topically with the leaf extract (250 mg kg−1body weight) whereas, control animals were treated with petroleum jelly. In the incision and dead space wound models, the test group animals were treated with extract (250 mg kg−1day−1) orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight and hydoxyproline content. On Day 15 extract-treated animals exhibited 100% reduction in the wound area when compared to controls (95%) with significant decrease in the epithelialization period. The extract failed to demonstrate antibacterial activity. Skin breaking strength (P< .001), wet (P< .002) and dry (P< .02) granulation tissue and hydroxyproline content (P< .03) were significantly higher in extract treated animals. The increased rate of wound contraction, skin breaking strength and hydroxyproline content supports potential application ofC. guianensisin wound healing.

scholarly journals In Vivo Wound Healing and Anti-Inflammatory Activities of Leaf Latex of Aloe megalacantha Baker (Xanthorrhoeaceae)

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Leake Gebremeskel ◽  
Dayananda Bhoumik ◽  
Gereziher Geremedhin Sibhat ◽  
Kald Beshir Tuem
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Negative Control ◽  
Wound Contraction ◽  
Traditional Use ◽  
Ointment Base ◽  
Healing Agent ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Background. Aloe megalacantha Baker (Xanthorrhoeaceae) is one of the Aloe species widely distributed in Ethiopia. The leaf latex of the plant is used for treatment of wounds, inflammation, and other multiple ailments in Ethiopian traditional medicine. Purpose. The aim of this study was to evaluate in vivo wound healing and anti-inflammatory activities of the leaf latex of Aloe megalacantha in mice. Methods. The wound healing activity of the leaf latex of the plant was studied topically by incorporating the latex in simple ointment base in a concentration of 5% (w/w) and 10% (w/w) using excision and incision models. In these models, wound contraction, period of epithelialization, and breaking strength of the wounded skin were determined. Carrageenan induced inflammation of paw model was also used to assess the anti-inflammatory activity of the leaf latex at doses of 200 mg/kg, 400mg/kg, and 600 mg/kg. The level of inflammation suppressions were measured at 1, 2, 3, and 4 hrs after carrageenan injection, and then the percentages of inflammation inhibition were computed as compared with the negative control. Result. In both wound models, mice treated with 5% (w/w) and 10% (w/w) latex ointment showed a significant (p<0.05) increment in the rate of wound contraction, reduction in epithelialization time, and higher skin breaking strength. Besides, the latex also exhibited a dose-dependent significant (p<0.05) reductions of inflammation as compared to negative control groups. Conclusion. The overall results of this study demonstrate that the leaf latex of A. megalacantha possesses wound healing and anti-inflammatory activities which can scientifically substantiate the traditional use of the plant as a wound healing agent.

scholarly journals In-vivo Evaluation of the Wound Healing Activity of the Sesamum Indicum L. Seed Extract in Novel Ethosomal Vesicular System

2018 ◽  
Vol 8 (5) ◽  
pp. 411-420 ◽  
Author(s):  
Sachin B Somwanshi ◽  
Shivanand N Hiremath
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Wistar Rat ◽  
Treated Group ◽  
Sesamum Indicum ◽  
Seed Extract ◽  
Wound Contraction ◽  
In Vivo Evaluation ◽  
Wound Healing Activity

Aim: To establish the wound healing activity of Sesamum indicum L. of seed extract in novel ethosomal vesicles. Methods: The ethosomal vesicles were formulated with prepared seed extract of Sesamum indicum L. by solvent evaporation method and characterized it. The optimized ethosomal vesicles then incorporated into gel base for further in vivo study in wistar rat. The evaluation of the wound healing activity was performed by using two models i.e. incision and excision models. In excision model percentage wound contraction and period of epithelialization were established for both the extracts. In incision model the parameter which was carried out was breaking strength of wounded skin. Results: The results revealed that the percentage wound contraction, period of epithelialization in excision model was enhanced than that of other groups and tensile strength of skin in incision model was similar to that of standard treated group. Keywords: Sesamum indicum L., Wound Healing, Ethosomal gel.

scholarly journals Evaluation of polyherbal ointment for wound healing activity in Wistar rats

2018 ◽  
Vol 8 (6-s) ◽  
pp. 26-31
Author(s):  
Shilpa S. Kolhe
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Breaking Strength ◽  
Skin Irritation ◽  
Wound Contraction ◽  
Alcoholic Extract ◽  
Polyherbal Formulation ◽  
Wound Healing Activity

The aim of present study to formulate, evaluate and to check the wound healing activity of newly prepared polyherbal formulation (ointment) .Herbal ointment containing hydrochloric extracts of plants Psorolea corylifalia, Achryanthes aspera ,was formulated as ointment and the hydro alcoholic extract was prepared by maceration method. These Formulations were evaluated for the following parameters: pH, Spread ability, grittiness, skin irritation study, stability. The wound healing activity is assessed by the rate of wound contraction, Period of epithelisation and skin breaking strength. Keywords: Herbal Ointment, Wound Healing Activity.

scholarly journals An Assessment of Wound Healing Potential ofArgyreia speciosaLeaves

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Kuldeep Singh Yadav ◽  
Narayan Prasad Yadav ◽  
Bindu Rawat ◽  
Vineet Kumar Rai ◽  
Karuna Shanker ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Breaking Strength ◽  
Present Report ◽  
Scientific Evidence ◽  
Water Extract ◽  
Wound Contraction ◽  
North India ◽  
Hydroxyproline Content ◽  
Traditional Use

In North India, poultice of young unfolded leaves ofArgyreia speciosaLinn. (Convolvulaceae) is used for healing wounds. In order to find scientific evidence for the traditional utilization of leaves ofA. speciosain wound healing, this investigation was carried out. A linear incision wound of about 3 cm in length and 2 mm in depth and circular excision wound of 177 mm2full thickness were made on the dorsal region of separate groups (n=5) of anesthetized Swiss albino mice. A simple ointment, developed by including ethanol, ethanol-water, and water extracts (10% each, separately) ofA. speciosa, was applied topically to mice once daily for 14 days after wounding. To evaluate the effect of each extract, wound contraction, epithelization period, wound breaking strength, and hydroxyproline content were determined. The water extract ofA. speciosashowed accelerated wound healing activity as evidenced by fast wound contraction (96.30±0.52%;P<0.01), rapid epithelization period (11.40±0.60days;P<0.001), greater wound breaking strength (376.56±21.16 g;P<0.001), and higher hydroxyproline content (16.49±1.12 mg/g;P<0.05) of granulation tissue. The present report supports the traditional use ofArgyreia speciosaleaves for wound healing and signify its relevant therapeutic potential.

Wound healing and cell regeneration after local freezing in stomach and small bowel

Cryobiology ◽  
1974 ◽  
Vol 11 (6) ◽  
pp. 579
Author(s):  
H. Bheining ◽  
B. Helpap ◽  
S. Langer ◽  
S. Lymberopoulos
Keyword(s):  
Wound Healing ◽  
Small Bowel ◽  
Cell Regeneration

scholarly journals Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

2013 ◽  
Vol 85 (3) ◽  
pp. 945-954 ◽  
Author(s):  
ISABELA K.R. AGRA ◽  
LUANA L.S. PIRES ◽  
PAULO S.M. CARVALHO ◽  
EURIPEDES A. SILVA-FILHO ◽  
SALETE SMANIOTTO ◽  
...  
Keyword(s):  
Wound Healing ◽  
Latin American ◽  
Aqueous Extract ◽  
Antimicrobial Properties ◽  
Inflammatory Cells ◽  
Stem Bark ◽  
Wound Contraction ◽  
Type I ◽  
Folk Remedy

The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of healing by wound contraction and period of epithelization at different days post-wound using the wound excisional model. On day 9, the AEBv-treated animals exhibited significative reduction in the wound area when compared with controls. In wound infected with S. aureus, the AEBv significantly improved the wound contraction when compared to the saline-treated mice. The histological analysis showed that AEBv induced a collagen deposition, increase in the fibroblast count and few inflammatory cells than compared to saline-treated group. The expression of collagen type I was increased in the group treated with AEBv as indicated by immunohistochemical staining. In vitro, the AEBv was effective only against S. aureus but not against P. aeruginosa. Together, the results of this study demonstrate, for the first time, the healing and antimicrobiological effects of aqueous extract of the stem bark from B. virgilioides in the therapy of skin wounds.

scholarly journals The use of aluminum slag waste in the preparation of roof tiles

2021 ◽  
Author(s):  
Marwa Ahmed ◽  
M. F. Abadir ◽  
Ayman Yousef ◽  
K. A. M. El-Naggar
Keyword(s):  
Mechanical Strength ◽  
Water Absorption ◽  
Cold Water ◽  
Breaking Strength ◽  
Drying Shrinkage ◽  
Smelting Process ◽  
Minimum Requirement ◽  
Roof Tile ◽  
Slag Waste ◽  
Clay Type

Abstract Aluminum slag waste generated from the smelting process of bauxite was used to prepare roof tiles samples. Clay was substituted by slag waste in percentages reaching 40% in the basic mix and the plasticity of the obtained mud was determined. This was followed by pressing the mud in steel molds and drying. The effect of waste addition on drying shrinkage was subsequently assessed. Firing of the green bodies was carried out at three temperatures (900, 1000 and 1100oC) and hour soaking at each temperature. Fired roof tile properties improved on increasing the percentage of alumina sludge and firing temperature possibly because of the presence of high amounts of fluxing oxides in aluminum slag. This caused a drop in porosity that increased the mechanical strength of tiles. The results showed that the substitution of clay by 40% waste and firing at 1100oC resulted in products conforming to ASTM C-1167 for clay type roof tiles. Cold water absorption dropped to 12%, below the maximum permissible limit of 15%, the value of Saturation Coefficient was 0.83, below the 0.86 limit and the obtained breaking strength of 3370N significantly exceeded the minimum requirement of 890N.

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