scholarly journals Pain Controlling and Cytokine-Regulating Effects of Lyprinol, a Lipid Extract ofPerna canaliculus, in a Rat Adjuvant-Induced Arthritis Model

2009 ◽  
Vol 6 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Chi-Ho Lee ◽  
John Hon-Kei Lum ◽  
Curtise Kin-Cheung Ng ◽  
Janice McKay ◽  
Yoki Kwok-Chu Butt ◽  
...  
Keyword(s):  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Similar Efficacy ◽  
Lipid Extract ◽  
Perna Canaliculus ◽  
Adjuvant Induced Arthritis ◽  
Pain Scores ◽  
Tnf Α ◽  
Control Pain

Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract ofPerna canaliculus(Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 9–14. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-α and IFN-γ, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract ofP. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.

scholarly journals The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 862
Author(s):  
Mireia Urpi-Sarda ◽  
Rosa Casas ◽  
Emilio Sacanella ◽  
Dolores Corella ◽  
Cristina Andrés-Lacueva ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Mediterranean Diet ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Inflammatory Biomarkers ◽  
Year Effect ◽  
Tnf Α ◽  
The Mediterranean ◽  
Anti Inflammatory

The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.

scholarly journals Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Rosa Casas ◽  
Mireia Urpi-Sardà ◽  
Emilio Sacanella ◽  
Sara Arranz ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Plasma Concentrations ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Inflammatory Biomarkers ◽  
Elderly Persons ◽  
Long Term Effects ◽  
Plaque Development ◽  
Atheroma Plaque

Objective.To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease.Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®.Results.At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β(P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group.Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

scholarly journals The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2855 ◽  
Author(s):  
Sara Carpi ◽  
Egeria Scoditti ◽  
Marika Massaro ◽  
Beatrice Polini ◽  
Clementina Manera ◽  
...  
Keyword(s):  
Olive Oil ◽  
Inflammatory Diseases ◽  
Virgin Olive Oil ◽  
Direct Interaction ◽  
Extra Virgin Olive Oil ◽  
Computational Studies ◽  
Related Gene ◽  
Expression Of Genes ◽  
Tnf Α ◽  
Cox 2

Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols of extra virgin olive oil (EVOO), such as the secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles in obesity-associated adipocyte inflammation, the NF-κB pathway and related sub-networks have not been fully elucidated. Here, we investigated impact of OC and OA on the activation of NF-κB and the expression of molecules associated with inflammatory and dysmetabolic responses. To this aim, fully differentiated Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were pre-treated with OC or OA before stimulation with TNF-α. EVOO polyphenols significantly reduced the expression of genes implicated in adipocyte inflammation (IL-1β, COX-2), angiogenesis (VEGF/KDR, MMP-2), oxidative stress (NADPH oxidase), antioxidant enzymes (SOD and GPX), leukocytes chemotaxis and infiltration (MCP-1, CXCL-10, MCS-F), and improved the expression of the anti-inflammatory/metabolic effector PPARγ. Accordingly, miR-155-5p, miR-34a-5p and let-7c-5p, tightly connected with the NF-κB pathway, were deregulated by TNF-α in both cells and exosomes. The miRNA modulation and NF-κB activation by TNF-α was significantly counteracted by EVOO polyphenols. Computational studies suggested a potential direct interaction between OC and NF-κB at the basis of its activity. This study demonstrates that OC and OA counteract adipocyte inflammation attenuating NF-κB activation. Therefore, these compounds could be novel dietary tools for the prevention of inflammatory diseases associated with obesity.

Comparing diets for weight loss and improvement in biomarkers in men with prostate cancer on surveillance: A pilot study.

2017 ◽  
Vol 35 (5_suppl) ◽  
pp. 159-159 ◽  
Author(s):  
Sharon Benson
Keyword(s):  
Prostate Cancer ◽  
Weight Loss ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Dietary Treatment ◽  
Extra Virgin Olive Oil ◽  
Increase Risk ◽  
Diet Compliance ◽  
Similar Weight

159 Background: Weight loss is recommended for treatment of prostate cancer, yet the most efficacious diet is not clear. The diet should improve biomarkers for prostate cancer, not increase risk of other chronic diseases, and be acceptable for long term use. Ascertaining appropriate dietary treatment for men on surveillance is crucial in preventing future cardiovascular disease, which is the leading cause of death in these men. Methods: Men with prostate cancer on surveillance and/or with untreated biochemical relapse followed 2 diets for 8 weeks of weight loss with random assignment to the order: (1) the diet recommended by the Prostate Cancer Foundation (PCF); (2) a plant-based, olive oil diet (PBOO), which included 3 tablespoons of extra virgin olive oil/ daily. After completing both diets, participants selected one of the diets for 6 months of follow-up (FU). Results: 30 started the protocol; 12 dropped out, 11 due to diet compliance (n = 3 PBOO; n = 8 PCF); 18 completed the 8 weeks of both diets and are reported here. Mean age: 66.6 + 5.9; baseline BMI: 30.9 + 2.7 kg/m2. Thirteen of the 18 have chosen the PBOO for FU. Conclusions: These results suggest a benefit with the PBOO diet in lowering insulin and glucose, and improving insulin function compared to the PCF diet. Despite similar weight loss, energy intake was higher on the PBOO diet. In addition, the PBOO diet was preferred over the PCF diet for long-term use. [Table: see text]

Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat

2010 ◽  
Vol 21 (4) ◽  
pp. 290-296 ◽  
Author(s):  
Michela Jacomelli ◽  
Vanessa Pitozzi ◽  
Mohamed Zaid ◽  
Mar Larrosa ◽  
Giulia Tonini ◽  
...  
Keyword(s):  
Olive Oil ◽  
Aging Process ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Phenolic Antioxidants ◽  
Long Term Effects

Long-Term Dietary Extra-Virgin Olive Oil Rich in Polyphenols Reverses Age-Related Dysfunctions in Motor Coordination and Contextual Memory in Mice: Role of Oxidative Stress

2012 ◽  
Vol 15 (6) ◽  
pp. 601-612 ◽  
Author(s):  
Vanessa Pitozzi ◽  
Michela Jacomelli ◽  
Dolores Catelan ◽  
Maurizio Servili ◽  
Agnese Taticchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Olive Oil ◽  
Motor Coordination ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Contextual Memory ◽  
Age Related

Effects of bag-in-box packaging on long-term shelf life of extra virgin olive oil

2021 ◽  
Author(s):  
Antonella De Leonardis ◽  
Vincenzo Macciola ◽  
Patrizio Spadanuda ◽  
Francesca Cuomo
Keyword(s):  
Shelf Life ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil
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