The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats

2008 ◽  
Vol 149 (2) ◽  
pp. 251-258 ◽  
Author(s):  
M. Singh ◽  
L.D. Hodges ◽  
P.F.A. Wright ◽  
D.M.Y. Cheah ◽  
P.M. Wynne ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Lipid Extract ◽  
Acid Extract ◽  
Crude Lipid ◽  
Perna Canaliculus ◽  
Adjuvant Induced Arthritis ◽  
Anti Inflammatory

scholarly journals Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

2011 ◽  
Vol 108 (42) ◽  
pp. 17533-17537 ◽  
Author(s):  
T. Wakimoto ◽  
H. Kondo ◽  
H. Nii ◽  
K. Kimura ◽  
Y. Egami ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Perna Canaliculus ◽  
Furan Fatty Acid ◽  
Anti Inflammatory ◽  
Inflammatory Component

scholarly journals Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis

2019 ◽  
Author(s):  
Katherine A. Murphy ◽  
Brian A. Harsch ◽  
Chastity L. Healy ◽  
Sonal S. Joshi ◽  
Shue Huang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Cardiac Myocytes ◽  
Transcriptome Analysis ◽  
Pressure Overload ◽  
Plasma Lipoproteins ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
Anti Inflammatory ◽  
Fatty Acid Receptor

AbstractBackgroundNon-­resolving activation of immune responses is central to the pathogenesis of heart failure (HF). Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor (GPR) for medium-and long-chain fatty acids (FA) that regulates metabolism and attenuates inflammation in diabetes and obesity. Here, we tested the hypothesis that Ffar4 functions as a cardioprotective nutrient sensor that resolves inflammation to maintain cardiac homeostasis.MethodsMice with systemic deletion of Ffar4 (Ffar4KO) were subjected to pressure overload by transverse aortic constriction (TAC). Transcriptome analysis of cardiac myocytes was performed three days post-TAC. Additionally, Ffar4-mediated effects on inflammatory oxylipin production in cardiac myocytes and oxylipin composition in plasma lipoproteins were evaluated.ResultsIn Ffar4KO mice, TAC induced more severe remodeling, identifying an entirely novel cardioprotective role for Ffar4 in the heart. Transcriptome analysis 3-days post-TAC indicated a failure to induce cell death and inflammatory genes in Ffar4KO cardiac myocytes, as well as a specific failure to induce cytoplasmic phospholipase A2α (cPLA2α) signaling genes. In cardiac myocytes, Ffar4 signaling through cPLA2α-cytochrome p450 ω/ω-1 hydroxylase induced production of the EPA-derived anti-inflammatory oxylipin 18-hydroxyeicosapentaenoic acid (18-HEPE). Systemically, loss of Ffar4 altered oxylipin content in circulating plasma lipoproteins consistent with a loss of anti-inflammatory oxylipins at baseline, and inability to produce both pro-inflammatory and pro-resolving oxylipins following TAC. Finally, we confirmed that Ffar4 is expressed in human heart and down-regulated in HF.ConclusionsOur results identify a novel function for Ffar4 in the heart as a FA nutrient sensor that resolves inflammation to maintain cardiac homeostasis.

scholarly journals Pain Controlling and Cytokine-Regulating Effects of Lyprinol, a Lipid Extract ofPerna canaliculus, in a Rat Adjuvant-Induced Arthritis Model

2009 ◽  
Vol 6 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Chi-Ho Lee ◽  
John Hon-Kei Lum ◽  
Curtise Kin-Cheung Ng ◽  
Janice McKay ◽  
Yoki Kwok-Chu Butt ◽  
...  
Keyword(s):  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Similar Efficacy ◽  
Lipid Extract ◽  
Perna Canaliculus ◽  
Adjuvant Induced Arthritis ◽  
Pain Scores ◽  
Tnf Α ◽  
Control Pain

Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract ofPerna canaliculus(Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 9–14. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-α and IFN-γ, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract ofP. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.

scholarly journals Screening of In-Vitro Anti-Inflammatory and Antioxidant Activity of Sargassum ilicifolium Crude Lipid Extracts from Different Coastal Areas in Indonesia

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 252
Author(s):  
Saraswati ◽  
Puspo Edi Giriwono ◽  
Diah Iskandriati ◽  
Nuri Andarwulan
Keyword(s):  
Cell Culture ◽  
Antioxidant Activity ◽  
Biological Activities ◽  
Coastal Areas ◽  
Lipid Extract ◽  
Cell Culture Model ◽  
Crude Lipid ◽  
Antioxidant Power ◽  
Culture Model ◽  
Anti Inflammatory

Sargassum brown seaweed is reported to exhibit several biological activities which promote human health, such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, and antioxidant activity. This study aimed to investigate the anti-inflammatory and antioxidant activity of crude lipid extracts of Sargassum ilicifolium obtained from four different coastal areas in Indonesia, namely Awur Bay–Jepara (AB), Pari Island–Seribu Islands (PI), Sayang Heulang Beach–Garut (SHB), and Ujung Genteng Beach–Sukabumi (UGB). Results showed that treatment of RAW 264.7 macrophage cells with UGB and AB crude lipid extracts (12.5–50 µg/mL) significantly suppressed the nitric oxide production after lipopolysaccharide stimulation, both in pre-incubated and co-incubated cell culture model. The anti-inflammatory effect was most marked in the pre-incubated cell culture model. Both two crude lipid extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and high ferric reducing antioxidant power, which were amounted to 36.93–37.87 µmol Trolox equivalent/g lipid extract and 681.58–969.81 µmol FeSO4/g lipid extract, respectively. From this study, we can conclude that crude lipid extract of tropical S. ilicifolium can be further developed as a source of anti-inflammatory and antioxidant agent.

scholarly journals Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2716
Author(s):  
Maciej Salaga ◽  
Adrian Bartoszek ◽  
Agata Binienda ◽  
Julia B. Krajewska ◽  
Adam Fabisiak ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Intestinal Inflammation ◽  
Feeding Habits ◽  
Inflammatory Activity ◽  
Intestinal Barrier Function ◽  
Pharmacological Intervention ◽  
Myeloperoxidase Activity ◽  
Trinitrobenzenesulfonic Acid ◽  
Anti Inflammatory

Diet is considered an important trigger in inflammatory bowel diseases (IBD), as feeding habits can affect intestinal permeability and clearance of bacterial antigens, consequently influencing the immune system. Free fatty acid receptors (FFARs), expressed on the intestinal epithelial cells, belong to the family of luminal-facing receptors that are responsive to nutrients. The objective of this study was to characterize the anti-inflammatory activity and the effect on intestinal barrier function of synthetic FFAR agonists in mouse models of colitis. Therapeutic activity of GW9508 (FFAR1 agonist), 4-CMTB (FFAR2 agonist), AR420626 (FFAR3 agonist), and GSK137647 (FFAR4 agonist) was investigated in two models of semi-chronic colitis: induced by trinitrobenzenesulfonic acid (TNBS), mimicking Crohn’s disease, as well as induced by dextran sulfate sodium (DSS), which recapitulates ulcerative colitis in humans. Moreover, we assessed the influence of FFARs agonists on epithelial ion transport and measured the ion flow stimulated by forskolin and veratridine. Administration of FFAR4 agonist GSK137647 attenuated both TNBS-induced and DSS-induced colitis in mice, as indicated by macroscopic parameters and myeloperoxidase activity. The action of FFAR4 agonist GSK137647 was significantly blocked by pretreatment with selective FFAR4 antagonist AH7614. Moreover, FFAR1 and FFAR4 agonists reversed the increase in the colon permeability caused by inflammation. FFAR4 restored the tight junction genes expression in mouse colon. This is the first evaluation of the anti-inflammatory activity of selective FFAR agonists, showing that pharmacological intervention targeting FFAR4, which is a sensor of medium and long chain fatty acids, attenuates intestinal inflammation.

scholarly journals Adiponectin Reverses the Hypothalamic Microglial Inflammation during Short-Term Exposure to Fat-Rich Diet

2019 ◽  
Vol 20 (22) ◽  
pp. 5738 ◽  
Author(s):  
Hannah Lee ◽  
Thai Hien Tu ◽  
Byong Seo Park ◽  
Sunggu Yang ◽  
Jae Geun Kim
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Energy Homeostasis ◽  
Metabolic Diseases ◽  
Short Term ◽  
Microglial Cell Line ◽  
Short Term Exposure ◽  
Hypothalamic Inflammation ◽  
Anti Inflammatory ◽  
Exogenous Treatment

Adiponectin, an adipokine derived from the adipose tissue, manifests anti-inflammatory effects in the metabolically active organs and is, therefore, beneficial in various metabolic diseases associated with inflammation. However, the role of adiponectin in alleviating the hypothalamic inflammation connected to the pathogenesis of obesity has not yet been clearly interrogated. Here, we identified that the systemic administration of adiponectin suppresses the activation of microglia and thereby reverses the hypothalamic inflammation during short-term exposure to a high-fat diet. Additionally, we show that adiponectin induces anti-inflammatory effects in the microglial cell line subjected to an exogenous treatment with a saturated free fatty acid. In conclusion, the current study suggests that adiponectin suppresses the saturated free fatty acid-triggered the hypothalamic inflammation by modulating the microglial activation and thus maintains energy homeostasis.

scholarly journals Acute Hepatitis Induced by Lyprinol, the Lipid Extract of the Green-Lipped Mussel (Perna canaliculus), in a Patient with Polyarthrosis

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Amr Abdulazim ◽  
Marion Hädrich ◽  
Matteo Montani ◽  
Nasser Semmo
Keyword(s):  
Rheumatoid Arthritis ◽  
Abdominal Pain ◽  
Side Effects ◽  
Acute Hepatitis ◽  
Lipid Extract ◽  
Complementary Treatment ◽  
Perna Canaliculus ◽  
Liver Transaminases ◽  
Supplementary Treatment ◽  
Anti Inflammatory

Lyprinol, the lipid extract of the green-lipped mussel (Perna canaliculus), is a readily and freely available agent with a putative anti-inflammatory impact. It has already found application as a complementary and supplementary treatment of osteoarthritis, rheumatoid arthritis, asthma, and cancer. So far no major side effects for Lyprinol have been reported, yet. Here, we present the case of a 76-year-old woman with acutely exacerbating abdominal pain and highly elevated liver transaminases while taking Lyprinol as a complementary treatment of polyarthrosis.

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